75N95020Q00276

Post Date/ Solicitation Issue Date

August 31, 2020 12:00 pm

Closing Response Date

September 10, 2020 3:00 pm

Proposed Award Date

September 21, 2020 12:00 pm

Project Title

Microscope

Contracting Office

National Institute on Aging (NIA)

Small Business Size Standard

Small

FPDS Classification Code

6640

Competition Status

Competitive

Background/Description of Requirement

 

Title: Chemical Library

 

DATE ISSUED: 8/31/2020

 

ISSUED BY CONTRACTING OFFICE:  Department of Health and Human Services, National

Institutes of Health, National Institute on Drug Abuse (NIDA), Office of Acquisition (OA)

 

FOR INFORMATION CONTACT:  Andrea Clay, 301-480-2449, amcgee@nih.gov

 

NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE: 334516 – Analytical Laboratory Instrument Manufacturing

 

CLASSIFICATION CODE:  6640

 

SMALL BUSINESS SIZE STANDARD: 1,000 employees

 

COMPETITION STATUS:  This requirement is competitive.

 

 

Date Quotation Due: All responses to this request for quote must be received by 3:00 PM Eastern Daylight Time, on September 10, 2020 and must reference the request number cited above.   Responses must be submitted electronically to the contact person cited above.  Fax responses will not be accepted.

 

IMPORTANT: This is a request for quotations. If you are unable to quote, please so indicate in a reply email to the point of contact cited herein.  This request does not commit the Government to pay any costs incurred in the preparation of the submission of a quotation or to contract for supplies or service. Supplies are of domestic origin unless otherwise indicated by quoter. Any representations and/or certifications attached to this Request for Quotation must be completed by the quoter.

 

Description of Requirement:

 

 

1. Statement of Need and Purpose:
   NCATS DPI is looking to expand its small molecules screening library. Adding diversity to chemical libraries is imperative to our operation, as we screen a variety of targets against these in-house collections.
    
2. Background Information and Objective:
   The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), whose mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

Screening is often the starting point in our development and a wealth of knowledge is obtained from screening a diverse collection. It provides the starting point of all information for medicinal chemistry’s structure-activity relationship (SAR) design to synthesize novel compounds that have more desirable properties. A diverse and novel screening collection provides the backbone of our operation and is imperative for translational sciences to obtain effective small molecules with on-target effects.

These small molecules have been designed around analysis of available chemical and biological information, identification of key pathways modules/targets, computational and “wet biology” assessment of target druggability and potential binding domains. The resulting information is analyzed by synthetic and medicinal chemistry teams to bring new chemical diversity and to design unique scaffolds that are likely to interact with the designated targets yielding focused compound libraries. Having such small molecules will make a huge impact in our screening against the variety of targets that NCATS works on and will also help tremendously in bioinformatics analysis which will allow a more thorough and effective SAR expansion by the medicinal chemist.

 

1. Generic Name of Product: Chemical Library.
    
   1. 1. Purchase Description: One (1) Chemical library of 76 compounds.
          
      2. Salient characteristics: N/A
          
      3. Quantity: One (1) Chemical library of 76 compounds.
          
          
      4. Delivery Date: One-time delivery to be made within 1-10 weeks after receipt of order.
          
          
          
          
         Quoter Terms and Conditions (To be completed by the Offeror):

1. Period of Performance OR Delivery Date After Receipt of Order:
2. Shipping Point (F.O.B. OR Destination):
3. Payment Discount Terms:
4. NIH BPA Number
5. DUNS No:
6. Name of Company:
7. Street Address, City, State, Zip code:
8. Name of Person Authorized to Provide Quote:
9. Telephone Number and Email Address of Person Authorized to Provide Quote:
    

Contract Type:

A Fixed-Price type of Purchase Order award not exceeding the Simplified Acquisition Threshold is anticipated for any contract resulting from this requirement. The anticipated award date is September 14, 2020.

 

ADDITIONAL TERMS AND CONDITIONS, PROVISIONS, AND REPRESENTATIONS

 

The FAR Clauses are incorporated by reference and are provided in full text at https://www.acquisition.gov/

1. 1. 1. 1. The provisions of FAR Clause 52.212-1 Instructions to Offerors—Commercial Items (OCT 2018) is applicable to this solicitation.
         2. The provisions of FAR Clause 52.212.2 Evaluation—Commercial Items (Oct 2014) is applicable to this solicitation. The Government will evaluate quotations or offers in accordance with FAR 13.106-2 and award a purchase order from this solicitation to the responsible offeror whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotes:
            1. 1. 1. 1. Technical capability of the item offered to meet the Government requirement;
                     2. Price; and
                     3. Past performance [see FAR 13.106-2(b)(3)].
         3. The provisions of FAR Clause 52.212-3, Offeror Representations and Certifications—Commercial Items (Dec 2019), is applicable to this solicitation.
         4. The provisions of FAR Clause 52.212-4, Contract Terms and Conditions—Commercial Items (OCT 2018) with Addenda: Stop Work Order, FAR Clause 52.242-15 (August 1989) is applicable to this solicitation.
         5. The provisions of FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items (Jul 2020) is applicable to this solicitation:
            52.222-3 Convict Labor (Jun 2003)
            52.222-19 Child Labor-Cooperation With Authorities and Remedies (Jan 2020)
            52.222-21 Prohibition of Segregated Facilities (Apr 2015)
            52.222-26 Equal Opportunity (Sep 2016)
            52.222-36 Equal Opportunity for Workers With Disabilities (Jun 2020)
            52.222-50 Combating Trafficking in Persons (Jan 2019)
            52.223-18 Encouraging Contractor Policies to Ban Text Messaging While Driving (Jun 2020)
            52.232-33 Payment by Electronic Funds Transfer-- System for Award Management (Oct 2018)

 

In addition, the following FAR provisions are applicable to this solicitation and incorporated by reference: 52.204-7 System for Award Management (Oct 2018),

52.204-13 System for Award Management Maintenance (Oct 2018),

52.204-16 Commercial and Government Entity Code Reporting (Jul 2016),

52.204-18 Commercial and Government Entity Code Maintenance (Jul 2016).

 

The following provisions and clauses apply to this acquisition and are incorporated as an attachment. Offerors MUST complete the provision at 52.204-24 and submit a completed copy as a separate document with their quotation.

1. FAR 52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Aug 2020)
2. FAR 52.204-25, Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment (Aug 2020)
3. FAR 52.204-26, Covered Telecommunications Equipment or Services-Representation (Dec 2019)
4. NIH Invoice and Payment Provisions (2/2014)

 

DELIVERY DATE:  1 to 10 weeks after receipt of order. Inspection and acceptance will be performed at NCATS located at 9800 Medical Center Drive, Rockville, MD 20852.  A firm fixed price type order is anticipated to be awarded as a result of this RFQ.

 

SUMMARY STATEMENT:

Responses to this notice must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service.  The response shall include: the unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision.  Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.