Contact Points
Primary Contract Specialist
The National Center for Advancing Translational Sciences (NCATS), Early Translation Branch (ETB), formerly known as the NCATS Chemical Genomics Center (NCGC), and originally the NIH Chemical Genomics Center, was created in 2008 as a comprehensive screening center in the Molecular Libraries Probe Production Centers Network, part of the NIH Common Fund’s Molecular Libraries Program. The ETB’s goal is to uncover new small molecule therapeutics and advance the process of therapeutic development through a model of collaborative research. For each collaboration, external disease experts’ team with the ETB’s drug discovery teams, who provide access to small molecule screening, medicinal chemistry and informatics expertise. Severe COVID-19 is often associated with cytokine storm, a state of systemic hyperinflammation that can result in severe tissue injury and ultimately death. One of the immune cell subsets that contributes to cytokine storm are macrophages. Primary monocytes (CD14+ or CD16+) are precursor cell type that differentiates into macrophages upon activation. We have established protocols for in vitro lung models to study SARS-CoV-2 infection. NCATS requires Human Peripheral Blood CD14+ and CD16+ Monocytes. The acquisition of primary monocytes will be used to differentiate into macrophages and subsequently introduced into our in vitro models to generate a more physiologically relevant platform to study SARS-CoV-2 pathology.
Purpose and Objectives: The purpose of this acquisition is to acquire ten (10) vials of CD14+ and ten (10) vials of CD16+ that meet all salient characteristics.
Purchase Description: Custom order of Human PB CD14+CD16- monocytes and Human PB CD14-CD16+ monocytes
Catalogue Number: 70096 (Custom-Immune, Cryo), 70114 (Donor request: CMV-)
Salient characteristics: Must be able to differentiate into M1 or M2 macrophages upon cytokine activation. Donor must be CMV-.
Delivery Dates: The first vial of CD14+ and CD16+ will be delivered on July 1, 2022, with the remaining vials being delivered the first of every month thereafter.
The Government anticipates award of a firm fixed-price purchase order for this acquisition. Delivery will be F.O.B. Destination. The place of delivery and acceptance will be NCATS, Bld. C, 9800 Medical Center Dr, Rockville, MD 20850.
The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html
(End of provision)
The following provisions apply to this acquisition and are incorporated by reference:
• FAR 52.204-7, System for Award Management (Oct 2018)
• FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020)
• FAR 52.211-6, Brand Name or Equal (Aug 1999)
• FAR 52.212-1, Instructions to Offerors-Commercial Items (Nov 2021)
• FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Nov 2021)
• FAR 52.225-4, Buy American-Free Trade Agreements-Israel Trade Act Certificate (Feb 2021)
• HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015)
The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses:
https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html
(End of clause)
The following clauses apply to this acquisition and are incorporated by reference:
• FAR 52.204-13, System for Award Management Maintenance (Oct 2018)
• FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020)
• FAR 52.212-4, Contract Terms and Conditions--Commercial Items (Nov 2021). Addendum to this FAR clause applies to this acquisition and is attached.
• HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015)
• HHSAR 352.239-74, Electronic and Information Technology Accessibility (December 18, 2015)
The following provisions and clauses apply to this acquisition and are attached in full text. Offerors MUST complete the provisions at 52.204-24 and 52.204-26 and submit completed copies as separate documents with their proposal.
• FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Nov 2021)
• FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020)
• FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Items (May 2022)
• NIH Invoice and Payment Provisions (April 2022)
(The provision at FAR clause 52.212-2, Evaluation – Commercial Items (Nov 2021), applies to this acquisition.
(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: (i) technical evaluation criteria or technical capability of the item offered to meet the Government requirement; and (ii) price.
Technical and past performance, when combined, are (1) significantly more important than cost or price.
(b) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award.
The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items (Nov 2021), with its offer. If the offeror has completed FAR clause 52.212-3 at www.sam.gov, then the offeror does not need to provide a completed copy with its offer.
The clause at FAR 52.212-4, Contract Terms and Conditions-Commercial Items (Nov 2021), applies to this acquisition. Addendum to this FAR clause applies to this acquisition and is attached as Attachment 3.
The following additional contract requirement(s) or terms and conditions as determined by the contracting officer are necessary for this acquisition and consistent with customary commercial practices. There are no additional contract requirement(s) or terms and conditions applicable to this acquisition.
The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.
Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance, special features required for effective program performance, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, and environmental and energy efficiency considerations.
Respondents proposing on an equal product of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order.
The Unique Entity Identifier (UEI), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All questions must be received by 11:00 a.m., Eastern Standard Time, on June 3, 2022, and reference Solicitation Number 75N95022Q00262. Questions may be submitted electronically to Kim Stapleton, Contract Specialist, at kim.stapleton@nih.gov.
All quotations must be received by11:00 a.m., Eastern Standard Time, on June 10, 2022, and reference Solicitation Number 75N95022Q00262. Responses must be submitted electronically to Kim Stapleton, Contract Specialist, at kim.stapleton@nih.gov.
Fax responses will not be accepted.
SUMMARY STATEMENT: Responses to this notice must include sufficient information to establish the interested parties bona-fide capabilities of providing the product or service. The response shall contain a quotation that includes the total price, as well as: the unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All responsible sources may submit a quotation which shall be considered by the agency.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM)
www.sam.gov
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.