NCATS-21-005222

Submitted by whipple on
Post Date/ Solicitation Issue Date
Closing Response Date
Proposed Award Date
Project Title
Gamm 33P Kinase Assay
Contracting Office
National Institute on Drug Abuse (NIDA)

Contact Points

Primary Contract Specialist

Thien
Nguyen
thien.nguyen2@nih.gov
NAICS Code Number
541380
1. This order provides for the testing of 60 compounds against the AKT1, LATS1 and LATS2 kinases in biochemical assay, specifically a gamma-33P-ATP assay with the purified kinase. This is also known as a "hotspot" assay. This testing will inform on kinase inhibitory activity in our compound series, and will facilitate further optimization and development of these AKT1 / LATS1 / LATS2 inhibitors as well as potential treatments.
Small Business Size Standard
Small Business
Estimated Period of Performance
8/20/21-8/19/21
Competition Status
Brand Name Only
Vendor Name
Reaction Biology Corporation
Vendor Address
One Great Valley Parkway Suite 2
Malvern, PA 19335
Single-Sole Source Determination
This requisition is for a gamma 33P-ATP biochemical kinase assay. The specific brand-name type of this type of assay is a "hotspot assay". To date, within this project, the contractor Reaction Biology has been providing the biochemical kinase data.
There can be significant differences in the assay values compared between contractors. For continuity of service and to be able to directly compare these results to past results, it is important to keep the same company as that which provided the previous services.

Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.