NIH-NINDS-21-011182 - Notice of Intent

Submitted by patelsnv on
Post Date/ Solicitation Issue Date
Closing Response Date
Proposed Award Date
Project Title
DNA-Encoded Chemical Library (DEL) Pre-Screen and Optimization Study
Contracting Office
National Institute of Neurological Disorders and Stroke (NINDS)

Contact Points

Primary Contract Specialist

Valerie
Gregorio
valerie.gregorio@nih.gov
NAICS Code Number
541714
Research and Development in Biotechnology (Except Nanobiotechnology)
Small Business Size Standard
1,000 employees
FPDS Classification Code
N/A
Estimated Period of Performance
August 1, 2021 - March 31, 2022
Delivery of Goods
BLDG 35 RM 2C-917
Set-Aside Status
Not Set Aside
Competition Status
Brand Name Only
Vendor Name
DyNAbind
Address
Tatzberg 47
Dresden, Sachsen
01307, Germany
Single-Sole Source Determination
4 DEL screening companies were researched: ZebiAI, X-Chem, HitGen, and DyNAbind. DyNAbind was selected because of the rigorous quality control standards, and better applicability of their identified compounds for downstream project needs. Although their library size is smaller than other vendors, the smaller library permits stricter quality control standards and is restricted to drug-like compounds. Therefore, a successful hit in their library is more likely to translate into a druggable molecule. As the goal of the project is to identify a druggable molecule for the ultimate purpose of treating Alzheimer’s Disease, DyNAbind’s service is uniquely suited for the project purpose. Also, DyNAbind has a dynamic fragment library to find combinations of compounds that bind together to create a stronger drug target. This unique approach means that their library, while smaller than other vendors, can match capacity of larger libraries with high quality control.
Background/Description of Requirement

The overall project goal is to identify small molecules that bind FIP200 and can be used to direct FIP200 to target Tau aggregates for autophagic elimination. The project will identify small molecules that bind the recombinant FIP200 protein using a high-throughput small molecule screening assay. However, optimal conditions need to be determined to ensure that the recombinant FIP200 domain will bind small molecule ligands prior to initiating this screen. 

Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.