NIH-NINDS - 22-003481 - Notice of Intent

Submitted by patelsnv on Wed, 01/05/2022 - 17:20
Post Date/ Solicitation Issue Date
Closing Response Date
Proposed Award Date
Project Title
CytoViVa Enhanced Darkfield Condenser and Liquid light
Contracting Office
National Institute of Neurological Disorders and Stroke (NINDS)

Contact Points

Primary Contract Specialist

NAICS Code Number
Analytical Laboratory Instrument Manufacturing
Small Business Size Standard
1,000 employees
FPDS Classification Code
Estimated Period of Performance
Delivery of Goods
BLDG 35 RM 3B205
Set-Aside Status
Not Set Aside
Competition Status
Brand Name Only
Vendor Name
Cytoviva, Inc
300 North Dean Road
Suite 5 - PMB 157
Auburn AL 36830
Single-Sole Source Determination
Market research has shown that only CytoViva Inc. can provide the CytoViva Enhanced Darkfield Illumination System and Liquid Light guide. While there are a variety of darkfield adapters available on the market, they are all of similar design and performance. In particular the CytoViva Illuminator offers simultaneous critical and Kohler illumination at the sample plane which in turn yields a signal that is ~10x higher than in standard darkfield. CytoViva is the only company in the marketplace offer such an illumination system.
Background/Description of Requirement

The CBBU at NINDS studies microtubules(MTs) and microtubule associated proteins(MAPs) and their interactions. Tubulin is one of the most prevalent proteins in the brain and the polymerized form, microtubule’s are essential for a wide variety of cellular phenomena. Perturbation to the microtubule cytoskeleton can lead to sever degrative disease. The construction and disassembly of microtubules is a very regulated process in cells. To understand the fundamental principles we apply label free darkfield imaging to microtubule sample in vitro. The acquisition on an enhanced darkfield condenser and liquid light guide will allow us to study this process at the single protofilament level and yield insights not currently achievable with existing equipment.  

Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM)

All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.