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Palo Alto, CA 94303
In addition, Inscopix, Inc. is the exclusive developer and manufacturer of the nVokeTM imaging system, which includes data acquisition software and data analysis software for large-scale imaging of calcium activity in freely behaving rodents. Moreover, Inscopix, Inc. is the original and only provider of the fully integrated imaging system technology that enables the Integrative Neuroscience Section to image large-scale cellular brain activity in freely-behaving rodents.
- Statement of Need and Purpose:
The purpose of this acquisition is to acquire the Inscopix nVoke2.0 Integrated Imaging and Optogenteics System for Rodents (nVoke2.0) and its associated software platform to conduct in vivo fluorescence imaging and optical stimulation in the mouse brain. This equipment is critical to the central mission of NINDS’ Integrative Neuroscience Section (INS): to study the neural basis of normal and disordered learning and memory processes.
The nVoke2 will replace and upgrade INS’s existing Inscopix nVista3.0 Integrated Imaging and Optogenteics System for Rodents, thereby expanding INS’s capability to perform in vivo imaging experiments to assess cell-type specific function and connectivity in the mouse brain. Unlike the nVista3.0, the nVoke2.0 facilitates simultaneous imaging and optical stimulation of neurons in the mouse brain. This particular equipment upgrade is available to INS only by Inscopix because the existing system was acquired from Inscopix and because only Inscopix is able to offer a trade-in value for the existing nVista 3.0 towards the price of the upgraded imaging system.
- Background Information and Objective:
Research performed in the Integrative Neuroscience Section (INS) probes the neural circuit basis of normal working memory, and characterizes the neural circuit and working memory dysfunction in a mouse models of genetic susceptibility to schizophrenia and related disorders. INS members use in vivo physiology to record the function of discrete cells and circuits in freely moving mice, and use optogenetic tools to control this function in real-time during behavior. INS focuses on understanding the neural computations within, and circuit-level interactions between, the prefrontal cortex (PFC), hippocampus, and thalamus of the mouse. The ability to conduct optical imaging of fluorescent indicators of neural activity in the brains of freely moving rodents is essential to this research.
- Generic Name of Product: Miniature microscope and associated software platform for simultaneous in vivo brain imaging and optical stimulation in freely moving rodents
4. Purchase Description:
Trade name: Miniature microscope for in vivo brain imaging and optical stimulation in freely moving rodents
Product brand name: Inscopix nVoke 2.0 Intergrated Imaging and Optogenteics System for Rodents
Manufacturer name: Inscopix
Model, type, catalog, and/or part number(s): nVoke 2.0
5. Salient Characteristics:
The Inscopix nVoke2.0 includes:
- nVoke2.0 microscope -fully integrated and assembled for immediate use
- DAQ box - allows for seamless communication with an external hardware device and coordinates or controls multiple devices during an experiment
- Inscopix Data Acquisition Software - includes device control for imaging LEDs and electronic focus via user-friendly programming with option for customizing scripts based on user capabilities
- Inscopix Data Processing Software - user-friendly GUI with options for user customization
- ProViewTM Implant Kit - specialized attachment device to hold lens during surgical procedures; includes stereotax rod, screw, adjustment tool, and instructions
- Five (5) lens probes, baseplates and baseplate covers – includes a variety of diameters or lengths of GRIN lens; straight or prism specified by user
- One voucherr to Inscopix' ACCELERATE training workshop - offers personalized learning modules and best practices, tailored to user’s interests and needs
- Included: unlimited technical and scientific support for duration of nVoke2.0 warranty at no additional cost
- Field scientific consultants who provide on-site training and continued support to the user
- Inscopix extended warranty program that covers all repairs to the nVoke system regardless of cause, and safeguards against unexpected maintenance costs as well as ensure quality, reproducible data sets.
6. Quantity: One (1)
7. Delivery Date: Within thirty (30) days after receipt of order
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.