Contact Points
Provide 24 hours response time
provide OEM manufactured product compatible with the government furnished equipment.
The Cellular Neurophysiology Unit focuses on circuit and cellular properties of dopaminergic neurons located in the midbrain. We are interested in the physiology of a subset of dopamine neuron located in the substantia nigra pars comacta (SNc) that undergo selective cell death in Parkinson’s patients. We are interested in understanding how synaptic and intrinsic conductances differ among subpopulations dopamine neurons with the hope that this may provide insight to why SNc dopamine neurons are particularly vulnerable in Parkinson’s disease. Our goal is to identify novel physiological and genetic markers in single SNc dopamine neurons which may be useful in defining subpopulations of these neurons in a meaningful way.
In order to examine dopamine neuron subpopulations, we need to be able to perform calcium imaging experiments in order to monitor their activity. In addition, we examine intracellular Ca in subcellular compartments in order to study how Ca contributes to cellular signal processing such as cellular firing activity and plasticity. In order to examine Ca signaling in different subcellular compartments, we use a two-photon microscope that uses a high-power Ti-sapphire laser such as the MaiTai laser that we would like to have repaired. Therefore, the Ti-sapph laser is essential equipment for our studies. The Ti-sapph (serial number 4902) laser is currently inoperable as the laser shutter seems to be broken and would not open. The contractor shall come onsite and perform troubleshooting and repair to return the equipment in optimal condition to allow NINDS researchers to continue research.
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