Repurposed arthritis drug could become a non-opioid pain reliever

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March 6, 2018

Flask in scientist hand with dropping liquid to test tube

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A compound once studied as an arthritis therapy has been given new life as a possible non-opioid pain reliever by NIDA-funded scientists. When used in combination with morphine, the cannabinoid agonist drug appears to block chemotherapy-induced neuropathic pain while decreasing signs of opioid dependence in mice.

Study:

Hohmann, et al. Slowly Signaling G Protein–Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Molecular Pharmacology. http://molpharm.aspetjournals.org/content/suppl/2017/11/30/mol.117.109355.DC1

NIDA. 2018, March 6. Repurposed arthritis drug could become a non-opioid pain reliever. Retrieved from https://archives.nida.nih.gov/news-events/science-highlight/repurposed-arthritis-drug-could-become-non-opioid-pain-reliever

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