Selected publications on the genetics of addiction for substances other than alcohol since Dec 31, 2013
Nicotine Genetics
- Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.
Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K. Transl Psychiatry. 2015 Oct 6;5:e651. doi: 10.1038/tp.2015.149 - Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.
Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Mol Brain. 2015 Aug 20;8:50. doi: 10.1186/s13041-015-0142-x. - Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Behav Genet. 2015 Sep 21. [Epub ahead of print] - The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption.
Kamens HM, Miyamoto J, Powers MS, Ro K, Soto M, Cox R, Stitzel JA, Ehringer MA. Neuropharmacology. 2015 Aug 25;99:639-649. doi: 10.1016/j.neuropharm.2015.08.035. [Epub ahead of print] - Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.
Olfson E, Saccone NL, Johnson EO, Chen LS, Culverhouse R, Doheny K, Foltz SM, Fox L, Gogarten SM, Hartz S, Hetrick K, Laurie CC, Marosy B, Amin N, Arnett D, Barr RG, Bartz TM, Bertelsen S, Borecki IB, Brown MR, Chasman DI, van Duijn CM, Feitosa MF, Fox ER, Franceschini N, Franco OH, Grove ML, Guo X, Hofman A, Kardia SL, Morrison AC, Musani SK, Psaty BM, Rao DC, Reiner AP, Rice K, Ridker PM, Rose LM, Schick UM, Schwander K, Uitterlinden AG, Vojinovic D, Wang JC, Ware EB, Wilson G, Yao J, Zhao W, Breslau N, Hatsukami D, Stitzel JA, Rice J, Goate A, Bierut LJ. Mol Psychiatry. 2015 Aug 4. doi: 10.1038/mp.2015.105. [Epub ahead of print] - Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.
Clark SL, McClay JL, Adkins DE, Aberg KA, Kumar G, Nerella S, Xie L, Collins AL, Crowley JJ, Quakenbush CR, Hillard CE, Gao G, Shabalin AA, Peterson RE, Copeland WE, Silberg JL, Maes H, Sullivan PF, Costello EJ, van den Oord EJ. Nicotine Tob Res. 2015 Aug 17. pii: ntv166. - Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis.
Leung T, Bergen A, Munafò MR, De Ruyck K, Selby P, De Luca V. Pharmacogenomics. 2015;16(7):713-20. doi: 10.2217/pgs.15.34. Epub 2015 May 7. - A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.
Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. Neuropsychopharmacology. 2015 Nov;40(12):2813-21. - Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis.
Leung T, Bergen A, Munafò MR, De Ruyck K, Selby P, De Luca V. Pharmacogenomics. 2015;16(7):713-20. doi: 10.2217/pgs.15.34. Epub 2015 May 7. - Strain-dependent performance in nicotine-induced conditioned place preference.
Kutlu MG, Ortega LA, Gould TJ. Behav Neurosci. 2015 Feb;129(1):37-41. - Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds.
Wilking JA, Stitzel JA. Neuropharmacology. 2015 Sep;96(Pt B):205-12 - The habenulo-interpeduncular pathway in nicotine aversion and withdrawal.
Antolin-Fontes B, Ables JL, Görlich A, Ibañez-Tallon I. Neuropharmacology. 2015 Sep;96(Pt B):213-22. - VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.
Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. Nat Neurosci. 2014 Dec;17(12):1751-8. - Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice.
Stoker AK, Marks MJ, Markou A. Eur J Pharmacol. 2015 Apr 15;753:146-50 - Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.
Bloom AJ, Hartz SM, Baker TB, Chen LS, Piper ME, Fox L, Martinez M, Hatsukami D, Johnson EO, Laurie CC, Saccone NL, Goate A, Bierut LJ. Ann Am Thorac Soc. 2014 Sep;11(7):1003-10. - Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.
Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI. Neuropsychopharmacology. 2015 Jan;40(2):350-60. doi: 10.1038/npp.2014.177. Epub 2014 Jul 18. - Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.
Shih PY, Engle SE, Oh G, Deshpande P, Puskar NL, Lester HA, Drenan RM. J Neurosci. 2014 Jul 16;34(29):9789-802. - Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.
Haller G, Li P, Esch C, Hsu S, Goate AM, Steinbach JH. PLoS One. 2014 May 7;9(5):e96753. doi: - Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers.
Zhu AZ, Zhou Q, Cox LS, David SP, Ahluwalia JS, Benowitz NL, Tyndale RF. Clin Pharmacol Ther. 2014 Aug;96(2):256-65. doi: 10.1038/clpt.2014.88. Epub 2014 Apr 14. - CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction.
Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S. Nicotine Tob Res. 2014 Sep;16(9):1224-31. - CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Lutz S, Rosenberger A, Aben KK, Andrew AS, Breslau N, Chang SC, Dieffenbach AK, Dienemann H, Frederiksen B, Han J, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden HF, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Heinrich J, Hokanson JE, Hunter DJ, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare D, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Kraft P, Amos CI, Bierut LJ. J Natl Cancer Inst. 2015 Apr 14;107(5). pii: djv100. doi: 10.1093/jnci/djv100. Print 2015 May. - Identification of CHRNA5 rare variants in African-American heavy smokers.
Doyle GA, Chou AD, Saung WT, Lai AT, Lohoff FW, Berrettini WH. Psychiatr Genet. 2014 Jun;24(3):102-9. doi: - Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.
Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Sci Rep. 2014 Mar 28;4:4497. - A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.
Dash B, Lukas RJ, Li MD. Neuropharmacology. 2014 Apr;79:715-25 - Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.
Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ. Addiction. 2014 May;109(5):814-22 - Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.
McClure-Begley TD, Papke RL, Stone KL, Stokes C, Levy AD, Gelernter J, Xie P, Lindstrom J, Picciotto MR. J Pharmacol Exp Ther. 2014 Mar;348(3):410-20 - Nicotine consumption is regulated by a human polymorphism in dopamine neurons.
Morel C, Fattore L, Pons S, Hay YA, Marti F, Lambolez B, De Biasi M, Lathrop M, Fratta W, Maskos U, Faure P. Mol Psychiatry. 2014 Aug;19(8):930-6. doi: 10.1038/mp.2013.158. Epub 2013 Dec 3. - Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.
Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF. Genes Brain Behav. 2014 Feb;13(2):213-25 - Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats.
Wang T, Han W, Wang B, Jiang Q, Solberg-Woods LC, Palmer AA, Chen H. Genes Brain Behav. 2014 - Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.
Wang S, D van der Vaart A, Xu Q, Seneviratne C, Pomerleau OF, Pomerleau CS, Payne TJ, Ma JZ, Li MD. Hum Genet. 2014 May;133(5):575-86 - Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.
Haller G, Kapoor M, Budde J, Xuei X, Edenberg H, Nurnberger J, Kramer J, Brooks A, Tischfield J, Almasy L, Agrawal A, Bucholz K, Rice J, Saccone N, Bierut L, Goate A. Hum Mol Genet. 2014 Feb 1;23(3):810-9. - Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability.
Fowler CD, Kenny PJ. Neuropharmacology. 2014 Jan;76 Pt B:533-44. - Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.
Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, Goate A. Hum Mol Genet. 2014 Jan 15;23(2):555-61. - Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).
Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L. Addiction. 2014 Jan;109(1):128-37 - Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.
Turner JR, Ray R, Lee B, Everett L, Xiang J, Jepson C, Kaestner KH, Lerman C, Blendy JA. Mol Psychiatry. 2014 Jul;19(7):801-10. doi: 10.1038/mp.2013.104. Epub 2013 Sep 3. - Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.
Loukola A, Wedenoja J, Keskitalo-Vuokko K, Broms U, Korhonen T, Ripatti S, Sarin AP, Pitkäniemi J, He L, Häppölä A, Heikkilä K, Chou YL, Pergadia ML, Heath AC, Montgomery GW, Martin NG, Madden PA, Kaprio J. Mol Psychiatry. 2014 May;19(5):615-24.
Opioid Genetics
- Replication of ZNF804A gene variant associations with risk of heroin addiction.
Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, Bierut LJ, Kral AH, Johnson EO. Genes Brain Behav. 2015 Sep 18. - A population-based association study of casein kinase 1 epsilon loci with heroin dependence in Han Chinese.
Wang Y, Zhu Y, Wang W, Wu F, Cui H, Xun X, Lai J. J Mol Neurosci. 2014 Jun;53(2):143-9. - Evidence of CNIH3 involvement in opioid dependence.
Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. Mol Psychiatry. 2015 Aug 4. - Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.
Glück L, Loktev A, Moulédous L, Mollereau C, Law PY, Schulz S. Biol Psychiatry. 2014 Nov 15;76(10):767-74 - Variations in opioid receptor genes in neonatal abstinence syndrome.
Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Drug Alcohol Depend. 2015 Oct 1;155:253-9 - Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.
Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, Hulse GK, Wildenauer D, Kelty EA, Schwab SG, Degenhardt L, Martin NG, Montgomery GW, Attia J, Holliday EG, McEvoy M, Scott RJ, Bierut LJ, Nelson EC, Kral AH, Johnson EO. Biol Psychiatry. 2015 Oct 1;78(7):474-84 - Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala.
Hou YY, Cai YQ, Pan ZZ. J Neurosci. 2015 Feb 25;35(8):3689-700. - Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area.
Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. Nat Neurosci. 2015 Mar;18(3):415-22. doi: 10.1038/nn.3932. Epub 2015 Feb 2. - Genome-wide association study of copy number variations (CNVs) with opioid dependence.
Li D, Zhao H, Kranzler HR, Li MD, Jensen KP, Zayats T, Farrer LA, Gelernter J. Neuropsychopharmacology. 2015 Mar;40(4):1016-26. doi: 10.1038/npp.2014.290. Epub 2014 Sep 27. - KCNH2 polymorphism and methadone dosage interact to enhance QT duration.
Hajj A, Ksouda K, Peoc'h K, Curis E, Messali A, Deveaux LL, Bloch V, Prince N, Mouly S, Scherrmann JM, Lépine JP, Laplanche JL, Drici MD, Vorspan F. Drug Alcohol Depend. 2014 Aug 1;141:34-8. - A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.
Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan YX. J Neurosci. 2014 Aug 13;34(33):11048-66 - OPRM1 A118G gene variant and postoperative opioid requirement: a systematic review and meta-analysis.
Hwang IC, Park JY, Myung SK, Ahn HY, Fukuda K, Liao Q. Anesthesiology. 2014 Oct;121(4):825-34. - Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants.
Levran O, Peles E, Randesi M, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ. Pharmacogenomics. 2014 Dec;15(16):2001-9. doi: 10.2217/pgs.14.145. - Genetics of opiate addiction.
Reed B, Butelman ER, Yuferov V, Randesi M, Kreek MJ. Curr Psychiatry Rep. 2014 Nov;16(11):504. doi: 10.1007/s11920-014-0504-6. Review. - A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.
Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan YX. J Neurosci. 2014 Aug 13;34(33):11048-66. - MeCP2 repression of G9a in regulation of pain and morphine reward.
Zhang Z, Tao W, Hou YY, Wang W, Kenny PJ, Pan ZZ. J Neurosci. 2014 Jul 2;34(27):9076-87. doi: 10.1523/JNEUROSCI.4194-13.2014. - The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.
Liang DY, Zheng M, Sun Y, Sahbaie P, Low SA, Peltz G, Scherrer G, Flores C, Clark JD. BMC Genomics. 2014 May 8;15:345. doi: 10.1186/1471-2164-15-345. - The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.
Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI. Br J Pharmacol. 2014 Aug;171(16):3845-57. - Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.
Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. Nat Neurosci. 2014 Feb;17(2):254-61. doi: 10.1038/nn.3622. Epub 2014 Jan 12. - Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.
Zhang Y, Picetti R, Butelman ER, Ho A, Blendy JA, Kreek MJ. Neuropsychopharmacology. 2015 Mar 13;40(5):1091-100. - Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107.
Lu Z, Xu J, Xu M, Pasternak GW, Pan YX. Mol Pharmacol. 2014 Feb;85(2):368-80. - Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Biol Psychiatry. 2014 Jul 1;76(1):66-74. - 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.
Charbogne P, Kieffer BL, Befort K. Neuropharmacology. 2014 Jan;76 Pt B:204-17. doi: 10.1016/j.neuropharm.2013.08.028. Epub 2013 Sep 10. Review. - Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K. Mol Psychiatry. 2014 Jan;19(1):55-62. doi: 10.1038/mp.2012.164. Epub 2012 Nov 27. - Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Addict Biol. 2014 Sep;19(5):955-64.
Cocaine Genetics
- C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.
Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS. Science. 2013 Dec 20;342(6165):1508-12. - Identification of long noncoding RNAs dysregulated in the midbrain of human cocaine abusers.
Bannon MJ, Savonen CL, Jia H, Dachet F, Halter SD, Schmidt CJ, Lipovich L, Kapatos G. J Neurochem. 2015 Oct;135(1):50-9. doi: 10.1111/jnc.13255. Epub 2015 Sep 1. - Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.
Gancarz AM, Wang ZJ, Schroeder GL, Damez-Werno D, Braunscheidel KM, Mueller LE, Humby MS, Caccamise A, Martin JA, Dietz KC, Neve RL, Dietz DM. Nat Neurosci. 2015 Jul;18(7):959-61. - Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action.
Chandra R, Francis TC, Konkalmatt P, Amgalan A, Gancarz AM, Dietz DM, Lobo MK. J Neurosci. 2015 May 20;35(20):7927-37. - Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action.
Chandra R, Francis TC, Konkalmatt P, Amgalan A, Gancarz AM, Dietz DM, Lobo MK. J Neurosci. 2015 May 20;35(20):7927-37. - SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens.
Ferguson D, Shao N, Heller E, Feng J, Neve R, Kim HD, Call T, Magazu S, Shen L, Nestler EJ. J Neurosci. 2015 Feb 18;35(7):3100-11. - Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients.
Corominas-Roso M, Roncero C, Daigre C, Grau-Lopez L, Ros-Cucurull E, Rodríguez-Cintas L, Sanchez-Mora C, Lopez MV, Ribases M, Casas M. Psychiatry Res. 2015 Feb 28;225(3):309-14. - Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine.
Enoch MA, Rosser AA, Zhou Z, Mash DC, Yuan Q, Goldman D. Genes Brain Behav. 2014 Nov;13(8):758-68. - Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine.
Okudaira N, Ishizaka Y, Nishio H. J Biol Chem. 2014 Sep 12;289(37):25476-85 - Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.
Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI. Neuropsychopharmacology. 2015 Jan;40(2):350-60. - Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.
Kreple CJ, Lu Y, Taugher RJ, Schwager-Gutman AL, Du J, Stump M, Wang Y, Ghobbeh A, Fan R, Cosme CV, Sowers LP, Welsh MJ, Radley JJ, LaLumiere RT, Wemmie JA. Nat Neurosci. 2014 Aug;17(8):1083-91. 140. - Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.
Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. PLoS One. 2014 May 9;9(5):e97216. - Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L. Genome Biol. 2014 Apr 22;15(4):R65. doi: 10.1186/gb-2014-15-4-r65. - Cell-type specific expression of p11 controls cocaine reward.
Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG. Biol Psychiatry. 2014 Nov 15;76(10):794-801. - Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.
Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Sci Rep. 2014 Mar 28;4:4497 - MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.
Deng JV, Wan Y, Wang X, Cohen S, Wetsel WC, Greenberg ME, Kenny PJ, Calakos N, West AE. J Neurosci. 2014 Mar 26;34(13):4519-27 - A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype.
Bannon MJ, Johnson MM, Michelhaugh SK, Hartley ZJ, Halter SD, David JA, Kapatos G, Schmidt CJ. Neuropsychopharmacology. 2014 Aug;39(9):2191-9. - G9a influences neuronal subtype specification in striatum.
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Genetics of Amphetamine
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