Contact Points
Primary Contract Specialist
Secondary Contracting Officer
Newark, CA 94560
Newark, CA 94560
I hereby determine that the RNAScope in situ hybridization probes and reagent kits listed herein is available from only one source, and competition is precluded for the reasons indicated below. There are no substitutes available.
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- Salient characteristics
- RNAscope® is a novel proprietary RNA in situ hybridization (ISH) method that enables routine detection and visualization of virtually any expressed gene in any tissue such as FFPE, Fresh frozen and fixed-frozen tissue.
- RNAscope® was designed to amplify target-specific signal without also amplifying the background signal, resulting in marked improvement in signal-to-noise ratio.This is accomplished by ACD’s patented double Z-probe design for in situ hybridization, where two independent probes (a double Z probe pair) are required to hybridize in tandem to the target sequence in order for signal amplification to occur. Since it is highly unlikely that two independent probes will hybridize to a nonspecific target right next to each other, this design concept ensures highly selective amplification of target-specific signals, therefore improving both sensitivity and specificity.
- Based on its patented probe design, RNAscope enables as much as 400-fold improvement over conventional RNA ISH, resulting in high detection sensitivity.
- Technology enables in situ detection of RNA molecules as small as 300bp, including degraded mRNA.
- ISH nature enables preservation of cellular and molecular context
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Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.