Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, morphine, and many others.  Learn about the health effects of prescription opioids and read the DrugFacts on Fentanyl, Heroin, and Prescription Opioids.

Opioid-involved overdose deaths rose significantly from 46,802 deaths in 2018 to 49,860 in 2019.

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Clinical Trials

Clinical trials are research studies in human volunteers conducted to answer specific health questions. Learn about the NIDA-sponsored clinical trials available to you