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PLEASANTON, CA 94588-3260
herein is available from only one source, and competition is precluded for the reasons
indicated below. There are no substitutes available meeting exact salient characteristics
other than TD
The UNAM’s research aims to investigate the spatial gene expression patterns in the human aPVT using the Visium HD spatial transcriptomics system. This technology allows for high-resolution mapping of RNA transcripts within tissue sections, providing a comprehensive spatial gene expression profile. The use of Visium HD will enable us to achieve the following objectives:
- Identify Molecular Markers and Pathways: By mapping the spatial distribution of gene expression in the aPVT, we can identify specific molecular markers and pathways that are implicated in regulating arousal and motivation. This information is crucial for understanding the mechanisms underlying mental health disorders.
- Compare Human and Rodent aPVT: Our previous work in rodents has revealed significant enrichment of genes such as GLIS3 in the aPVT. Using Visium HD, we can directly compare the gene expression profiles between human and rodent aPVT, facilitating the translation of mechanistic insights from animal models to human conditions.
- Advance Therapeutic Strategies: By identifying key genes and pathways involved in the aPVT, we can pave the way for developing targeted therapeutic strategies for treating neuropsychiatric disorders. Understanding the molecular architecture of the aPVT will help in designing interventions that modulate its function, potentially alleviating symptoms of conditions like PTSD and bipolar disorder.
- Generate High-Resolution Spatial Data: The Visium HD system will provide us with high-resolution spatial transcriptomics data, allowing for precise mapping of RNA transcripts within the aPVT. This will enable us to uncover the complex gene expression landscapes that underlie the functional roles of the aPVT.
Given the scientific importance of the aPVT and its potential involvement in mental health disorders, the acquisition of the Visium HD system is essential for advancing our research. This investment will significantly enhance our ability to perform state-of-the-art spatial transcriptomics, contributing valuable knowledge to the field of neuroscience and improving our understanding of thalamic function in health and disease.
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