Contact Points
The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.
The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), whose mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.
NCATS is in need of scale up synthesis of the c-Abl project’s lead compound, NCGC00508975. This fee for service will entail the scale up synthesis of 250g of the c-Abl lead compound NCGC00508975. This scale up material will be used for preclinical development of the c-Abl project.
NCATS is in need of scale up synthesis of the c-Abl project’s lead compound, NCGC00508975. This fee for service will entail the scale up synthesis of 250g of the c-Abl lead compound NCGC00508975.
This service should provide the following deliverables:
- Execute a multistep synthesis and produce 250 grams of the lead compound NCGC00508975.
Level of Effort
NCATS will provide medicinal chemistry route and experimental details of the multistep synthesis
of the lead compound NCGC00508975.
Delivery Or Deliverables
Vendor is responsible for providing the following deliverables:
- 250 grams of NCGC00508975.
- Material shall have a purity greater than 98% (>98% by HPLC).
- Material shall have certificate of analysis, including, but not limited to 1H-NMR, LC-MS.
- Weekly progress reports and final report including detailed protocols of synthesis, chromatography conditions and analytics for each step provided to Andres Dulcey (dulceyan@mail.nih.gov) and Juan Marugan (maruganj@mail.nih.gov) at NCATS via email.
Reporting Requirements
Vendor will be responsible for providing weekly progress reports and presentations to Andres Dulcey (dulceyan@mail.nih.gov) and Juan Marugan (maruganj@mail.nih.gov) at NCATS via email or conference calls as service work is rendered.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.