Contact Points
Ongoing research projects in SCTL focus on understanding molecular mechanisms regulating stem cell pluripotency and their multi-lineage differentiation capabilities with a focus on defining optimum culture conditions for maintaining pluripotent stem cells and their conversion to homogeneous and mature population of differentiated cells. To achieve these aims, SCTL performed rigorous internal tests of a variety of stem cell culture systems and small molecules from several vendors and concluded that small molecules and proteins from R&D Systems meets our specific requirement, including supporting stem cell pluripotency maintenance, multi-lineage differentiation and 3-D culture. Numerous batches of cells have been grown using R&D small molecules and the result was consistent and predictable growth resulting in successful assays performed at NIH NCATS.
Generic Name of Product:
CHIR 98014 - N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
Recombinant Human Jagged 1 Fc Chimera Protein, CF
Recombinant Human DLL1 His-tag Protein, CF
Recombinant Human BDNF Protein, CF
Recombinant Human beta-NGF Protein
Recombinant Human CNTF Protein
Recombinant Human NT-3 Protein
PD 173074
Recombinant Human BMP-7 Protein
Recombinant Human LIF Protein
Recombinant Human BMP-5 (CHO-expressed) Protein
Purchase Description:
Small molecules are formulated for best stability and are lyophilized from a sterile filtered solution. They are available without or with a carrier protein, usually bovine serum albumin (BSA) at 50 mg/mg of protein.
Salient Characteristics:
Small molecules are in solution and ready to use
Each protein is tested to rule out microbial contamination using direct plating and broth dilution, according to guidelines from the United States Pharmacopeia (USP)
Quantity:
5 units of CHIR 98014
5 units of Recombinant Human Jagged 1 Fc Chimera Protein, CF
5 units of Recombinant Human DLL1 His-tag Protein, CF
5 units of Recombinant Human BDNF Protein, CF
5 units of Recombinant Human beta-NGF Protein
5 units of Recombinant Human CNTF Protein
5 units of Recombinant Human NT-3 Protein
5 units of PD 173074
5 units of Recombinant Human BMP-7 Protein
5 units of Recombinant Human LIF Protein
5 units of Recombinant Human BMP-5 (CHO-expressed) Protein
Delivery Date
4 weeks After Receipt of Order
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