75N95022Q00526

Post Date/ Solicitation Issue Date

August 15, 2022 12:00 pm

Closing Response Date

August 25, 2022 9:00 am

Proposed Award Date

August 29, 2022 12:00 pm

Project Title

Structural Studies of Chorismate Mutase from M. tuberculosis in Complex with Peptide Inhibitors

Contracting Office

National Center for Advancing Translational Sciences (NCATS)

Small Business Size Standard

$16.5M

FPDS Classification Code

Q301

Estimated Period of Performance

9/1/2022 - 8/31/2023

Competition Status

Competitive

Single-Sole Source Determination

N/A

Background/Description of Requirement

REQUEST NUMBER: 75N95022Q00526

 

DATE ISSUED: August 15, 2022

 

ISSUED BY CONTRACTING OFFICE:  Department of Health and Human Services / National Institutes of Health / National Institute on Drug Abuse (NIDA)/ OA / 301 N Stonestreet Ave, Bethesda, MD 20892

 

FOR INFORMATION CONTACT:  Kevin Alvarez, kevin.alvarez@nih.gov

 

NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE:  541380

 

SMALL BUSINESS SIZE STANDARD: $16.5M

 

SET-ASIDE STATUS: N/A

 

Competition Status:  This requirement is being conducted using full and open competition.

 

Non-Competitive (Single-sole Source (Including brand-name)) Determination: N/A

 

DATE QUOTATION DUE:

All responses to this RFQ must be received by 9:00 AM Eastern, on August 25, 2022 and must reference the request number cited above. Responses must be submitted electronically to the contact person cited above. Fax responses will not be accepted.

 

IMPORTANT: This is a request for quotations. If you are unable to quote, please so indicate in a reply email to the contract specialist cited herein.  This request does not commit the Government to pay any costs incurred in the preparation of the submission of this quotation or to contract for supplies or service. Supplies are of domestic origin unless otherwise indicated by quoter. Any representations and/or certifications attached to this Request for Quotation must be completed by the quoter.

 

Requirement Description

 

NCATS requires crystallization services to obtain structural information for the chorismate mutase enzyme from M. tuberculosis (MtCM) in complex with five peptide inhibitors for a total of five structures. This fee-for-service crystallography data is critical to better characterize the enzyme binding to our novel cyclic peptide inhibitors in this ongoing, high priority project, and will be used in critical decision points to guide further cyclic peptide development aimed at new anti-infective agents.

 

This service shall provide the five MtCM:peptide inhibitor complexes.

 

Each subproject (MtCM:peptide inhibitor complex) will require two service tasks that will be completed sequentially as follows:

1. Crystallization Screening and Data Collection
2. Structure Determination

 

The Government is responsible for providing purified chorismate mutase enzyme from M. tuberculosis (MtCM) and peptide inhibitors.

 

Vendor is responsible for providing all X-ray diffraction data obtained, with data analysis and final structure coordinates in a report, to be delivered to the PI. All data should be summarized for each compound batch, and included in an electronic report, deliverable to James Inglese

(jinglese@mail.nih.gov) at NCATS via email within 8 weeks after the receipt of each round of

research materials.

 

*Note: Shipping cost must be included as a separate line item in any quote submitted or indicated if it is included in the total price of the quotation.

 

Delivery/Warranty

Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or warranty or software licenses applicable. Inspection and acceptance will be performed at NCATS located at 9800 Medical Center Drive, Rockville, MD 20852.

 

An estimated number of days for delivery after receipt of an order must be specified in any quote submitted. Delivery terms anticipated for FOB-Destination shall apply.

 

Contract Type:

A Fixed-Price type of Purchase Order award not exceeding the Simplified Acquisition Threshold is anticipated for any contract resulting from this requirement. The anticipated award date is August 25, 2022.

 

QUOTER TERMS AND CONDITIONS (to be filled out by the Offeror):

1. Period of Performance OR Delivery Date After Receipt of Order:
2. Shipping Point (F.O.B. OR Destination):
3. Payment Discount Terms:
4. Select One: Open Market; GSA FSS Contract Number; Other Government Agency (OGA) Contract Number, Government-wide Agency (GWAC) Contract Number; or National Institute of Health (NIH) Blanket Purchase Agreement (BPA) Number:
5. DUNS No:
6. Name of Company:
7. Street Address, City, State, Zip code:
8. Name of Person Authorized to Provide Quote:
9. Telephone Number and Email Address of Person Authorized to Provide Quote:

 

ADDITIONAL TERMS AND CONDITIONS, PROVISIONS, AND REPRESENTATIONS

The FAR Clauses are incorporated by reference and are provided in full text at https://www.acquisition.gov/

1. 1. 1. 1. The provisions of FAR Clause 52.212-1 Instructions to Offerors—Commercial Items (OCT 2018) is applicable to this solicitation.
         2. The provisions of FAR Clause 52.212.2 Evaluation—Commercial Items (Oct 2014) is applicable to this solicitation. The Government will evaluate quotations or offers in accordance with FAR 13.106-2 and award a purchase order from this solicitation to the responsible offeror whose quote conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotes:
            1. 1. 1. 1. Technical capability of the item offered to meet the Government requirement;
                     2. Past performance [see FAR 13.106-2(b)(3)].
         3. The provisions of FAR Clause 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services, is applicable to this solicitation.
         4. The provisions of FAR Clause 52.212-4, Contract Terms and Conditions—Commercial Products and Commercial Services, applies to this acquisition.
         5. The provisions of FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items is applicable to this solicitation:

 

In addition, the following FAR provisions are applicable to this solicitation and incorporated by reference: 52.204-7 System for Award Management (Oct 2018),

52.204-13 System for Award Management Maintenance (Oct 2018),

52.204-16 Commercial and Government Entity Code Reporting (Aug 2020),

52.204-18 Commercial and Government Entity Code Maintenance (Aug 2020).

52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services of Equipment (Nov 2021)

HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (December 18, 2015).

52.212-4(g), Invoice, is supplemented by the NIH Invoice and Payment Instructions (4/2022).

52.225-2, Buy American Certificate

 

Offerors MUST complete the provision at 52.204-24 (attached) and submit a completed copy as a separate document with their quotation.

 

SUMMARY STATEMENT:

Responses to this notice must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service.  The response shall include a QUOTATION that includes: unit price, list price, total price, any shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision.  Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

 

HHS reserves the right to exercise priorities and allocations authority with respect to this contract, to include rating this order in accordance with 45 CFR Part 101, Subpart A - Health Resources Priorities and Allocations System.

 

Attachments:

1. FAR 52.212-5
2. Copy of FAR 52.204-24, to be completed and submitted by offeror
3. Invoice and payment provisions