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The significant, essential physical, functional, performance, or material element(s) that are the Government’s minimum acceptable standards for an equivalent system to meet the government’s objective are as follows:
An equivalent high-precision low noise digitizer system shall:
• be able to sample at 500 kHz per channel.
• be able to digitize a wide range of input signals from -10 to +10V.
• have the capability to eliminate line-frequency noise that eliminates 50/60 Hz line-frequency noise pattern associated with high-frequency line harmonics.
• be compatible with pClamp 11 software that is used for acquisition of electrophysiology.
The high-precision low noise digitizer system shall be warranted, and the Contractor shall warrant its equipment against defects in material, fabrication, or workmanship for a minimum of one (1) year from the date of installation, inspection by the Government, and acceptance. Warranty shall not include routine or periodic maintenance services.
The purpose of this requirement is to acquire Molecular Devices, LLC Digidata 1550B1 Low Noise Data Acquisition system or equal for the National Institute of Neurological Disorders and Stroke (NINDS), Neurovascular Research Unit. This electrophysiological equipment is used for examining the cellular excitability and ion channel distributions in the microvascular cells of the brain.
Background Information and Objective: The NINDS mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease for all people.
Research in the NINDS Neurovascular Research Unit focuses on different neurovascular coupling mechanisms in control of the blood flow in the brain. This Unit also examines functional deficits in molecular mechanisms in the small vessel diseases of the brain and Vascular Cognitive Impairment & Dementia (VCID) including Stroke and Alzheimer’s disease. We rely on functional imaging approaches (in-vivo and ex-vivo) and electrophysiology to answer scientific questions.
To study the signaling properties of cells that comprise the neurovascular system, this laboratory uses patch clamp electrophysiology, which allows its researchers to perform precise measurements of ion channel activities in different vascular cells. To record the activity associated with individual ion channels, there is a need for a high-precision digitizer system for collecting data through the acquisition software pClamp11, which will allow the laboratory to accurately measure sub millivolt (very small) changes in the membrane potential of cells associates with individual ion channel activity.
The brand-name item the Unit identified that meets the need of this procurement is Molecular Devices, LLC Digidata 1550B1 Low Noise Data Acquisition system (Part Numbers DIGIDATA 1550B1 and PCLAMP 11 STANDARD), which relies on imaging capabilities to study human stem cell-derived neurons.
Generic Name of Product: High-precision low noise digitizer system
Purchase Description:
Manufacturer: Molecular Devices LLC
Trade Name: Digidata 1550B1 Low Noise Data Acquisition System
Part Numbers: DIGIDATA 1550B1
Manufacturer: Molecular Devices LLC
Trade Name: pClamp 11 software for windows
Part Numbers: PCLAMP 11 STANDARD
Salient characteristics: The significant, essential physical, functional, performance, or material element(s) that are the Government’s minimum acceptable standards for an equivalent system to meet the government’s objective are as follows:
An equivalent high-precision low noise digitizer system shall:
- be able to sample at 500 kHz per channel.
- be able to digitize a wide range of input signals from -10 to +10V.
- have the capability to eliminate line-frequency noise that eliminates 50/60 Hz line-frequency noise pattern associated with high-frequency line harmonics.
- be compatible with pClamp 11 software that is used for acquisition of electrophysiology.
The high-precision low noise digitizer system shall be warranted, and the Contractor shall warrant its equipment against defects in material, fabrication, or workmanship for a minimum of one (1) year from the date of installation, inspection by the Government, and acceptance. Warranty shall not include routine or periodic maintenance services.
Quantity: One (1) system and software
Delivery Date: The Contractor shall deliver the equipment described above within 60 days after receipt of order (ARO). The equipment shall be delivered to the NINDS delivery address under Purchase Description 8. below between the hours of 8:00 am and 5:00 pm, Eastern Daylight Time, Monday through Friday (except federal holidays). Delivery shall be Freight on Board (FOB) destination and shall include inside delivery. Details of delivery and installation shall be coordinated with the Contracting Officer’s Representative (COR).
Delivery Requirements:
Neurovascular Research Unit, NINDS
Building 35A / Room 3D-973
35A Convent Dr.
Bethesda, MD 20892
Period of Performance: Not applicable.
Option(s): Not applicable.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.