75N95024Q00525

This requisition establishes a contract to manufacture 56 antisense oligonucleotides (ASOs) commercially for in-vivo test in mice. These ASOs are the necessary starting material to be used to evaluate if a platform based on liver spheroid cell cultures can be used for the rapid and reliable prediction of hepatotoxicity associated with administering ASOs. The antisense oligonucleotides will be used for research and require high sequence specificity and purity. 

IDT DNA will synthesize and deliver 56 antisense oligonucleotides targeting the human genome. The antisense oligonucleotides will be customized, synthesized, HPLC or desalt purified, and diluted to the required quantity and concentration. NCATS will supply the specific sequence and chemical modifications of the 56 ASOs to be synthesized by IDT.

IDT DNA will synthesize and deliver 56 antisense oligonucleotides. The antisense oligonucleotides will be customized according to sequences specified by NCATS. The antisense oligonucleotides will be synthesized, purified using standard desalting methods, and normalized to the required quantity and concentration. ASOs will be delivered dry/powder in appropriate tubes (1-2 ml).

ESTIMATED PERIOD OF PERFORMANCE:

The Period of Performance is 2 weeks ARO

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION

The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, IDTDNA, Integrated DNA Technologies is the only vendor in the marketplace that can provide the services required by NCATS.

The intended source is:

IDTDNA, Integrated DNA Technologies, Inc. 

1710 Commercial Park, Coralville, Iowa 52241, USA

CLOSING STATEMENT

THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. 

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. 

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95024Q00525. Responses must be submitted electronically to Patricia da Silva, Contract Specialist, at patricia.dasilva@nih.gov and KJ Shaikh, Contracting Officer, at kj.shaikh@nih.gov U.S. Mail and fax responses will not be accepted.