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The Functional and Restorative Neurosurgery Unit (FRNU) exploits the unique investigative opportunities provided by intracranial electrical recordings during neurosurgical procedures such as epilepsy monitoring and implantation of deep brain stimulators. Using these recordings captured from patients implanted with intracranial electrodes, the Zaghloul lab investigates the activation of cortical networks during memory encoding and recall, and the role of the basal ganglia in learning and decision-making. The investigational use of these novel high density probes will give FRNU the ability to record from up to 128 channels per implantation site, significantly increasing the amount of data collected during surgical cases. The ability to record from large populations of neurons in deep brain structure is critical to the advancement of the scientific understanding of human cognition.
The Deep Array product is an investigational brain probe that has been developed and validated over the past four years, resulting in an electrode technology that is uniquely suited to high density interfaces with laminar neuronal circuitry including in deep structures in the brain. These electrodes are investigational and not yet commercially available.
Specifications:
- Biocompatible 128-channel electrode micro-array
- Micro-engineered thin polymer film, onto which high density electrode arrays and interconnect are lithographically patterned at high resolution (micron scale)
- Electrode sites electroplated with a conducting polymer that reduces site impedance
- Flexible array is transferred to a thin (0.2mm-diameter) stainless steel carrier of up to 90mm in length, after which it can be inserted stereotactically and used in vivo with or without a surgical micro-drive
Advantages over existing electrodes include: the ability to address deep and laminar targets, the ability to interface with large numbers of single neurons with up to 128 channels, and the ability to reliably separate the single unit activity of a large number of neurons, simultaneously.
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