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The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) seeks to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS, one of twenty seven Institutes and Centers (ICs) at NIH, strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. NCATS is distinctive in its focus on collaboration with outside investigators to produce high-quality chemical probes to define and assess new biology. This focus is reflected in our unprecedented outreach program, which reaches hundreds of potential new investigators every year, and accounts for much of the new science being done at the NCATS.
PT-2977 is an orally available inhibitor of hypoxia inducible factor 2-alpha (HIF-2alpha), currently in phase II clinical development at Merck & Co. for the treatment of patients with von Hippel-Lindau disease-associated renal cell carcinoma. The acquisition of fifteen grams of PT-2977 would allow to further investigate its activity profile in combination with other chemotherapeutic agents in animal models.
The purpose of this requirement is the acquisition of fifteen grams of PT-2977 (CAS: 1672668-24-4). The material will be provided with chemical purity exceeding 95% and enantiopurity exceeding 95%.
The Contractor shall verify the following:
- Characterization and delivery of fifteen grams of PT-2977 (CAS: 1672668-24-4).
- Chemical purity to exceed 95% and enantiopurity to exceed 95%. The appropriate documentation (LC-MS trace, proton NMR, carbon NMR spectra, chiral HPLC trace) demonstrating these purity levels will be provided.
The Contractor will deliver fifteen grams of PT-2977 (CAS: 1672668-24-4) in a clearly labeled bottle or vial. The material will be provided with chemical purity exceeding 95% and enantiopurity to exceed 95%. The Contractor will provide a copy of the certificate of analysis including the analytical data demonstrating the purity of the final product.
The Contractor should provide weekly updates on the progress of the project, or more often as appropriate.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.