DA20-002736

Post Date/ Solicitation Issue Date

April 1, 2020 12:00 pm

Closing Response Date

April 13, 2020 12:00 pm

Proposed Award Date

April 17, 2020 12:00 pm

Project Title

Ezymes by R&D Systems

Contracting Office

National Institute on Drug Abuse (NIDA)

Small Business Size Standard

1250 employees

FPDS Classification Code

6505

Estimated Period of Performance

NA

Delivery of Goods

3 days After Receipt of Order

Competition Status

Brand Name Only

Single-Sole Source Determination

The brand name supply is required for consistency of prior data results and reproducibility of previous data.

Background/Description of Requirement

The Division of Preclinical Innovation (DPI) at the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) seeks to obtain chemical enzymes for High signal and detection for HTS applications, expressed in E. coli with C-terminal His tags and Quality control tested for Concentration, Purity, Endotoxin, and Activity. The DPI Chemical Genomics Center regularly screens its small molecule library collections against different enzymes that are implicated in development of diseases. Target class profiling is a screening approach that characterizes a set of enzymes with functional similarities to improve the efficiency of lead compound identification. In this case COMT, NNMT, HNMT, GNMT and PNMT are two methyltransferases with similar structure and catalytic mechanism but differing biological outcomes. This makes them suitable candidates to being target class profiling studies of the natural product methyltransferases. The enzymes produced by R&D Systems are rigorously tested for purity and activity prior to shipping and required to further launch the NCATS’ target class profiling campaign.  Specifically, this RFQ requires the following supply of enzymes: PNMT (catalog # 7854-MT), HNMT (catalog # 7637-MT), GNMT (catalog # 6526-MT), NNMT (catalog # 7736-MT), and COMT (catalog # 7386-MT) by R&D Systems. 

Specifically, the following items shall be delivered with FOB Destination terms to NCATS located at 9600 Medical Center Drive in Rockville, MD in the following quantities as a one-time shipment.

Offerors submitting a quotation may use the following table to quote prices or in another similar table format.

Catalog number	Qty	List Price	Discounted Bulk Price	Lead Time
7736-MT-010	15 x 10ug	to be specified	to be specified	to be specified
6526-MT-010	15 x 10ug	to be specified	to be specified	to be specified
7386-MT-010	15 x 10ug	to be specified	to be specified	to be specified
7854-MT-020	8 x 20ug	to be specified	to be specified	to be specified
7637-MT-010	15 x 10ug	to be specified	to be specified	to be specified
Shipping cost		to be specified	to be specified

*Note: Shipping cost must be included as a separate line item in any quote submitted or indicated if it is included in the total price of the quotation.

Delivery/Warranty

Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or warranty or software licenses applicable. Inspection and acceptance will be performed at NCATS located at 9800 Medical Center Drive, Rockville, MD 20852.

The Government anticipates delivery within 1 week after contractor receipt of order. An estimated number of days for delivery after receipt of an order must be specified in any quote submitted. Delivery terms anticipated for FOB-Destination shall apply.

Contract Type:

A Fixed-Price type of Purchase Order award not exceeding the Simplified Acquisition Threshold is anticipated for any contract resulting from this requirement. The anticipated award date is January 10, 2020.