NIH-NINDS - 22-011852 - Notice of Intent

Submitted by patelsnv on Tue, 07/26/2022 - 13:26
Post Date/ Solicitation Issue Date
Closing Response Date
Proposed Award Date
Project Title
10X Genomics Chromium Kits
Contracting Office
National Institute of Neurological Disorders and Stroke (NINDS)

Contact Points

Primary Contract Specialist

NAICS Code Number
Analytical Laboratory Instrument Manufacturing
Small Business Size Standard
1,000 employees
FPDS Classification Code
Estimated Period of Performance
Delivery of Goods
BLDG 10 RM 5C103
Set-Aside Status
Not Set Aside
Competition Status
Brand Name Only
Vendor Name
10X Genomics, Inc.
6230 Stoneridge Mall Road
Pleasanton, California, 94588-3260
United States
Single-Sole Source Determination
10X Genomics is the only vendor that can provide their trademarked chromium kits. These kits are required to continue ongoing research and we must continue to use the
same kits. The most recent POTS order placed for these items, which we referred to for this order, is POTS 22-008723.
Background/Description of Requirement

The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the National Institutes of Health (NIH), conducting research into the causes, treatment, and prevention of neurological disorders and stroke. PML is an opportunistic infection of the brain for which currently there is no cure.  The Experimental Immunotherapeutics Unit conducts a clinical research program dedicated to advancing our understanding of the pathophysiology of PML and the development of treatments.  To this end, there is an urgent need to improve our understanding of risk factors for this disease as well as development of biomarkers.  Magnetic resonance imaging is key for the diagnosis of the disease and for monitoring clinical course. However, in vivo imaging lacks histopathological specificity. One of the objectives of our group is detailed histopathological-radiological correlation studies. 10x Visium technology provides a way to investigate the molecular basis for magnetic resonance imaging findings, and to advance our understanding of the pathophysiology of this disease through acquisition of a spatial map of mRNA expression and organization of resident neuronal and glial cells and infiltrating immune cells from formalin fixed tissue.



Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM)

All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.