Contact Points
constitutes the best-characterized tissue resource in DLB in the world. No other
repositories exist that could provide these samples.
bodies (DLB) cases within the Newcastle Brain Tissue Resource constitute the bestcharacterized
collection of pathologically confirmed DLB samples in the world. We
previously performed whole-genome sequencing on 88 DLB cases from this brain bank,
and the current request is a continuation of our research efforts to map the genetic
architecture of this understudied type of dementia. No other repositories exist that could
provide these samples. The project would not be able to proceed without access to
these samples. This would impede our efforts to fulfill the mission of our laboratory to
understand the causes of this fatal dementia syndrome, which affects 1.4 million
Americans. It would also negate the value of the previous government expenditure used
to perform whole genome sequencing on the original 88 DLB samples from this brain
bank.
Age-related neurodegenerative conditions place a growing and substantial socioeconomic burden on U.S. society. There is an unmet need to understand the genetic determinants of Lewy body dementia (LBD), a fatal neurodegenerative disease affecting about 1.4 million Americans. We will perform whole-genome sequencing in DNA samples from patients diagnosed with LBD to apply modern gene discovery tools and expand the LBD genomic resource (https://amp-pd.org/unified-cohorts/lbd) for the research community. Increasing the number of cases with LBD for genomic investigations will allow us to identify novel risk factors and accelerate the pace of discovery in the understudied disease. This project is central to the mission of our laboratory to understand the genetic causes of neurodegenerative diseases that are killing millions of Americans.
We previously performed whole genome sequencing on 88 DLB cases from this brain bank, and the current request is a continuation of our research efforts to map the genetic architecture of this understudied type of dementia. No other repositories exist that could provide these samples. The project would not be able to proceed without access to these samples. This would impede our efforts to fulfill the mission of our laboratory to understand the causes of this fatal dementia syndrome. It would also negate the value of the previous government expenditure used to perform
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