Contact Points
• The Microtome must include integrated control of vertical blade deflection in the Z-axis
• Vertical deflection in the Z axis must be calibrated by the manufacturer and recalibration between specimens not required
• Due to the space constraints, the Microtome must have a footprint of 13” x 11” x 8” and weigh 13.5 lbs or less for portability
• The Microtome must include 5-year limited warranty
The Mitochondrial Biology and Neurodegeneration Unit (MBNU) focuses on mitochondrial dysfunction in genetic forms of Parkinson’s disease. MBNU researchers investigate the roles of specific mitochondrial proteins (including Parkin, PINK1, CHCHD2, and CHCHD10) in which specific mutations are linked to several neurogenerative diseases. Understanding how these mutations alter mitochondrial structure and function to cause disease is crucial to developing therapies that reduce severity or prevent disease. The vibrating blade microtome will be used to slice tissues such as heart, brain, skeletal muscle, liver, and other tissues for a variety of ongoing experimental applications including live-tissue cultures and fixed tissue immunohistochemistry and electron microscopy. Tissue sections of thicknesses varying from ~1 microns to 999 microns are routinely needed for functional assays and studies of mitochondrial ultrastructure, protein localization, organelle distribution and cell organization in various tissues. A vibrating blade microtome is needed in the laboratory to produce tissue slices of live and fixed tissue that are highly consistent in thickness and minimally damaged by the slicing process.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.