NINDS-NOI-20-007352

1. Statement of Need and Purpose:
   The Synapse and Neural Circuits Section (SNCS) of the National Institute of Neurological Disorders and Stroke (NINDS) requires a telemetry system capable of recording dynamic, electrophysiology signals in mice during sleep, general anesthesia, and wake stages.  The mouse wireless electrophysiology monitoring system is needed to conduct more in-depth research studies of the GABAergic mechanism of general anesthetics driven by the Shisa7 protein.

2. Background Information and Objective: 
   The wireless electrophysiology monitoring system will be used in studies and experiments on mice focused on the novel protein Shisa7, which has been found to affect GABAAR trafficking and which has a strong correlation with the pharmacology general anesthetics such as propofol, etomidate, and isoflurane and others widely used in clinical surgery.

3. Generic Name of Product:   
   Wireless Electrophysiology Monitoring System (includes hardware and software)

4. Product Description:  The NINDS SNCS requires a wireless mouse electrophysiology monitoring system that is brand name or equal to ViewPoint Life Sciences’ Oneiros Mouse Electrophysiology Monitoring System (wireless version) (Equipment) and has the following salient specifications/characteristics:   

5. Salient Specifications/Characteristics:

• Able to record and display eight (8) electrophysiological signals including electroencephalogram, electromyogram, electrooculogram, and electrocardiogram on separate channels in real time
• Three (3) temperature monitoring channels
• Equipped with three (3) Oneiros (or equal) transmitters and receivers including one (1) headstage transmitter – can acquire either eight (8) biopotential signals with up to 8000Hz sampling rate in mice or twenty-six (26) biopotential signals with up to 8000Hz sampling rate in rats, one (1) digital signal receiver – can receive transmissions up to 3 meters away, and one (1) implantable transmitter/receiver
• Equipped with 3-axis (X, Y, Z) accelerometer that measures global accelerations
• Magnetic activation capable
• Includes ten (10) implantable electronic interface boards (skull connectors)
• Low input referred noise amplifier: 2,4 microvolts rms
• Low power, 16-bit analog digital converter
• Measuring range: +/- 6 to 4 millivolts
• Includes one (1) perpetual Oneiros Ephylab software license for Windows 10 Pro with online updates for 12 months and digital user manual
• Includes one (1) multicore CPU with at least 3Ghz processing speed and 4 GB ram, Windows 10 Pro OS installed, one (1) National Instruments PCIe-6343 multifunction data acquisition card (or equal), one (1) 22” LCD monitor, one (1) keyboard (English), and all required cables. Hardware and software must be configured for advanced features of ZebraLab software.
• Includes remote (online) installation and setup of all above-described system components
• Includes three (3) online training sessions of two hours each for SNCS users:
• Includes twelve months unlimited online and telephone-based support

      6. Quantity:  

          As indicated in the “Salient Specifications/Characteristics” section above.   

      7. Delivery Terms:

The Contractor shall deliver all above described Equipment within thirty (30) days after receipt of order. The Equipment shall be delivered to: National Institutes of Health, 35 Convent Drive, Building 35A, Room 3C-1000, Bethesda, Maryland 20892. D Delivery must must be (freight on board) (F.O.B.) destination, including inside delivery. 

Installation and setup of the Equipment shall take place within two (2) weeks after delivery and acceptance and be performed remotely by ViewPoint Life Sciences or the wireless electrophysiology monitoring system manufacturer in coordination with Dr. Wei Lu.

Remote training sessions shall take place within one (1) week after installation and setup. The Contractor shall coordinate training sessions with Dr. Wei Lu.

      8. Other Considerations:

The Contractor shall warrant tall Equipment against material or workmanship defects for a period of twelve (12) months from the date of installation.  All service and repairs required within this warranty period shall be performed by certified, trained technicians of ViewPoint Life Sciences or the original equipment manufacturer (OEM). Technicians shall have the ability to troubleshoot Equipment malfunctions remotely. diagnose the systems on site via remote access.  The Contractor shall provide without delay any required replacement parts for the Equipment during warranty period.