Primary Contract Specialist
Madison, WI 53711
The Cellular Neurophysiology Unit focuses on circuit and cellular properties of dopaminergic neurons located in the midbrain. We are interested in the physiology of a subset of dopamine neuron located in the substantia nigra pars comacta (SNc) that undergo selective cell death in Parkinson’s patients. We are interested in understanding how synaptic and intrinsic conductances differ among subpopulations dopamine neurons with the hope that this may provide insight to why SNc dopamine neurons are particularly vulnerable in Parkinson’s disease. Our goal is to identify novel physiological and genetic markers in single SNc dopamine neurons which may be useful in defining subpopulations of these neurons in a meaningful way.
In order to examine dopamine neuron subpopulations, we need to be able to perform calcium imaging experiments in order to monitor their activity. In addition, we examine intracellular Ca in subcellular compartments in order to study how Ca contributes to cellular signal processing such as cellular firing activity and plasticity. In order to examine Ca signaling in different subcellular compartments, we use a two-photon microscope that we would like to have repaired. Therefore, the two-photon microscope is essential equipment for our studies.
The purpose of our requirement is to have a maintenance and repair visit by authorized factory trained engineer to address specific problem with the computer and currently non-functional. The equipment were damaged by the BLDG 35 Flood over the winter holiday and researches are delayed due to the equipment non-functioning.
Interested parties may identify in writing their interest and capability in response to this requirement. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by closing date and must reference the announcement. Responses may be submitted electronically to the attention of the contract specialist. Fax responses will not be accepted.
All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.