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Research in the Neurovascular Research Unit focuses on different neurovascular coupling mechanisms in control of the blood flow in the brain. We also examine functional deficits in molecular mechanisms in the small vessel diseases of the brain and Vascular Cognitive Impairment & Dementia (VCID) including Stroke and Alzheimer’s disease. We rely on functional imaging approaches (in-vivo and ex-vivo) and electrophysiology to answer scientific questions.
In order to study the signaling properties of cells that comprise the neurovascular system, our lab uses patch clamp electrophysiology. This approach allows us to perform precise measurements of ion channel activities in different vascular cells. In order to record the activity associated with individual ion channels, we need a high-precision amplifier for collecting data through the acquisition existing electrophysiology equipment. This will allow us to accurately measure submillivolt changes in the membrane potential of cells associates with individual ion channel activity.
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