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Optogenetics is a modern tool that gives us an incredible ability to control neuronal activities by light illumination. Traditionally, fiber optics have been used to deliver light to different brain areas. However, development of chronically implantable illumination devices dramatically improved the quality of optogenetic experiments particularly in non-human primates. In the Laboratory of Neuropsychology (LN) at the NIMH, we have been using Opto-Array, a chronically implantable array of micro-LEDs for high-throughput optogenetic perturbation.
The main advantage of NeuroLux Optogenetics System is that the implanted micro-LEDs can be controlled wirelessly, the implants does not have external antennas, external connectors, any batteries, or external head mount. The micro-LEDs and power system are fully implantable and ultra-lightweight (less than a gram). The flexible light sources operate wirelessly, across nearly any experimental environment with user-definable pulse frequencies and durations. The system can be configured to meet the needs of many different circumstances. The complete system comes with a laptop and user-friendly GUI, and an initial set of disposable implants. Two control boxes provide RF wireless control and power delivery that are suitable for a wide variety of enclosures.
Northfield, Illinois
60093-2744, United States
This acquisition is restricted to: NeuroLux, 191 Waukegan Rd., Suite 104, Northfield, IL 60093 Email: sales@neurolux.org
Furthermore, this system provides a less invasive approach for optogenetic experiments in non-human primates. External implants often shorten the life of implanted devices, since the external connectors in other light delivery tools make the tissue prone to local infection, and even the animal to systematic infections such as meningitis. Moreover, lightweight and small dimensions of these implants would solve the physical limitations that we had with our current optogenetic systems. Unlike other systems in the market, this system also allows us to perform in-cage optogenetic experiments in non-human primates without transferring them to the lab. This eliminates using head restraining devices requiring other invasive procedures for implanting head-post. In summary, the above-mentioned characteristics of this device creates less invasive and safer experiment design for optogenetic experiments in non-human primate. Additionally, this device opens the door to in-cage optogenetic experiments, where the animals are performing more natural behaviors.
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