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Ample evidence shows methadone and buprenorphine reduce overdose deaths, prevent the spread of diseases like HIV, and enable people to take back their lives, but there are restrictions on who...
Research Highlights
A look at drug craving
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Studies using animal models of addiction have shown that drug seeking progressively increases after drug self-administration stops, which is a phenomenon called incubation of drug craving.
E-Cigs linked to heart attacks
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An analysis of health data concludes that e-cigarette use, adjusted for smoking conventional cigarettes and other risk factors, is associated with increased risk of myocardial infarction, which is commonly known...
Proven Prevention Program Aims To Adapt for Native Americans
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This research showed: A survey that is a key tool in the Communities That Care prevention system is largely valid in Native American communities. Adjusting the survey to incorporate culturally...
Mindfulness training and substance use treatment
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A NIDA-funded study showed that a mindful awareness training program is associated with improved outcomes for women seeking treatment for substance use disorders.
A New Tool for Investigating HIV in the Brain
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In this research: Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in...
How cannabis use disorder affects working memory
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Using imaging technologies, NIDA-funded scientists peered into the brains of people with cannabis use disorder to test their working memory, compared to a control group.
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Some teens's marijuana use has been linked to disrupted communication between two key regions in the brain's reward circuitry at age 20. Disrupted communication between the regions was associated with...
E-Cigarettes Promote Smoking Progression in Youth and Depress Quitting Among Adults
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E-cigarettes are not an effective tool to reduce combustible-cigarette smoking, two NIDA-supported studies indicate.
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This research: Sheds light on a key mechanism of adolescent brain development. Shows how amphetamine disrupts this mechanism. Links this disruption to animal behaviors that resemble human susceptibility to addiction...
Pregnant women in Appalachia face barriers to opioid treatment
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A NIDA-funded study has discovered that pregnant women in Appalachia face barriers to receiving medication-assisted treatment for opioid use disorders, from both insurers and providers.
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Reducing healthcare’s reliance on potentially addictive opioid pain relievers has been one of the pillars of federal efforts to reverse the opioid crisis.
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This week, the Food and Drug Administration (FDA) approved Epidiolex (cannabidiol, or CBD), a medication extracted from marijuana, for the treatment of two severe pediatric seizure disorders.
As Opioid Use Disorders Increased, Prescriptions for Treatment Did Not Keep Pace
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Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to...
A revealing look at the brain on heroin
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A NIDA-funded study reveals major changes in the brains of heroin users.
Scientists discover path to better pain medicines
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In this this NIDA-funded research, scientists used a novel approach to compare the cell signaling initiated by kappa opioids that produce dysphoria from those that do not.
Outcomes of Computerized CBT Rival Those of Clinician-Delivered CBT
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This clinical trial: Found that patients who self-administered cognitive behavioral therapy (CBT) using computerized training modules reduced their drug use as much as patients who received clinician-delivered CBT, and they...
In Animals, Opioid Combination Shows Promise for Safer Pain Relief
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This study found that: In rats, co-administration with nalfurafine reduced the dose of oxycodone required to lower pain responses in models of human chronic pain. The combination treatment generated less...
Novel Compound Alleviates Hard-to-Treat Pain in Mice
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A novel compound called GAT211 alleviates inflammatory and neuropathic pain in mice without producing tolerance or signs of abuse liability.
A Gene Links Impulsivity and Drug Use Vulnerability
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This research: Identified a gene variant that promotes impulsive behavior and enhanced responses to heroin in rats. Linked the corresponding human gene variant to increased risk for impulsivity and drug...
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In spring 2018, Congress added an additional $500 million to the NIH budget to invest in science to find solutions to the opioid crisis. The funding that NIDA is receiving...
Too Hot And Too Cold: Dysregulation of key brain networks in people with addiction
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Study suggests that brain activity is not simply too high or low in people who are addicted to drugs, but behaves differently to drug and non-drug stimuli.
Cigarette Smoking Increases the Likelihood of Drug Use Relapse
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This research: Found that cigarette smoking increased the likelihood of relapse among people in recovery from substance use disorder (SUD). Suggests that helping patients quit and remain abstinent from smoking...
Breathing under the influence of … fentanyl
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An animal study at NIDA's intramural research labs suggests fentanyl-induced respiratory depression affects the temperature of the brain, triggering brain hypoxia and hyperglycemia.
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This week, the Food and Drug Administration (FDA) approved lofexidine, the first medication targeted specifically to treat the physical symptoms associated with opioid withdrawal.
What science says about Tobacco + Marijuana + Pregnancy
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A NIDA-funded study suggests that pregnant women who smoke both marijuana and cigarettes have a higher likelihood of smaller babies and increased maternal stress and aggression.
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New data-gathering and analytic capabilities are enabling the kinds of massive, long-term studies needed to investigate genetic, environmental, and lifestyle factors that contribute to disease.
Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 3
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Dr. Linda Dwoskin feels just one small step away from success in her effort to develop the first-ever medication to treat methamphetamine addiction. She and colleagues at the Universities of...
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Today, a new analysis in JAMA by epidemiologists at NIDA and the Substance Abuse and Mental Health Services Administration reveals the scope of the crisis, and the rapidity with which...
Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients
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In this research: Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics. Neither pain severity nor...