Medication Treatment of Opioid Use Disorder Can Protect Against Overdose Death
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Fewer overdose deaths occurred among adults treated with opioid agonist medications than among those not treated with medication.
Research Highlights
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New guidance for researchers establishes a standard THC unit of 5 milligrams.
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A public health approach to drug addiction is critical for population well-being and health equity
Childhood Caffeine Exposure May Negatively Affect Cognitive Functioning
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For most assessed cognitive functions, the negative correlation remained after controlling for age, gender, socioeconomic status, and sleep.
Mourning the Loss of a Great Addiction Pioneer
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Remembering Dr. Mary Jeanne Kreek, a great addiction pioneer and longtime NIDA grantee.
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse
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Inhibition of KORs using a short-acting selective antagonist significantly prevented escalation of cocaine intake in rats during chronic exposure and during re-exposure after withdrawal.
Awareness and Use of Pre-Exposure Prophylaxis for HIV Rise in At-Risk Groups, But Not Enough
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Use of pre-exposure prophylaxis to prevent contracting HIV increased among men who have sex with men from 2013 to 2017.
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NIH Director Francis Collins announces UNITE, an NIH-wide initiative to end structural racism in biomedical science
Using Smartphone Apps to Reach Gay and Bisexual Men at Risk for HIV
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Finding better ways to reach people at higher risk of HIV for testing and engagement with HIV prevention and treatment services is a critical component of a public health response...
Disrupting Cocaine Memories Prevents Return to Cocaine Use in Rats
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Preventing cocaine memories from re-strengthening in an unstable period following retrieval attenuates cocaine seeking.
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Inherent in the mission of NIH is that biomedical research and its application can and should benefit all people
Human Opioid Exposure Can Be Measured Using Wastewater
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Using robotic technology, local levels of opioid metabolites can be measured in wastewater from individual manholes
Co-located HIV Services Can Help Women Who Inject Drugs Access PrEP, Study Shows
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Daily, PrEP (pre-exposure prophylaxis medication), is proven to prevent HIV transmission from injection drug use or sex.
Skewed Opioid Prescribing Patterns in the United States—A Few Providers Prescribe a Large Proportion of Opioids
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Only 1 percent of the providers who prescribe opioids account for almost half of all opioid doses prescribed and one-quarter of opioid prescriptions written.
ADAPT-2 Trial Results Deliver a Breakthrough in Long Search for Methamphetamine Use Disorder Medication
| En español
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A combination of bupropion and naltrexone successfully reduced methamphetamine use
People With SUDs Have Increased Risk for COVID-19 and Worse Outcomes
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People with a substance use disorder (SUD) at any time in their lives are 1.5 times more likely to contract COVID-19 than those without an SUD, and those with a...
Substance Use Status Important When Developing HIV Therapies
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Animal studies suggest that subjects with HIV who suffer from opioid use disorders may have higher viral reservoirs in the central nervous system than non-opioid users.
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Patients in treatment for opioid use disorder (OUD) who were more comfortable making decisions when they did not know the probability of outcome had a higher risk of using opioids...
Unraveling neuroHIV in the Presence of Substance Use Disorders
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These reviews address how each of these addictive substances and HIV individually or collectively affect the immune system and subsequent clinical and behavioral outcomes
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NIDA-funded research aims to help understand teen drug use and its effects
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A specific collection of neurons in the basolateral amygdala, a brain region crucial for affect, was active when mice experienced pain. Deactivating this collection of neurons resulted in a loss...
Elite Controllers May Hold Key to an HIV Cure
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"Science" Magazine Breakthrough of the Year Runner Up for 2020
On World AIDS Day, Celebrating Scientific Advances and Confronting the Complexities of HIV and Substance Use
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We applaud the substantial strides made, while recognizing the challenges that need to be addressed.
HIV and Methamphetamine Use: Double Jeopardy for Transmission of the Novel Coronavirus.
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The authors suggest that co-occurring methamphetamine use and HIV present a double jeopardy for COVID.
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There is an alarming increase in deaths involving the stimulant drugs methamphetamine and cocaine.
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People with SUDs may be particularly vulnerable to COVID-19 and its most adverse health outcomes
Narrative of Discovery: The Quest for a Medication to Treat Methamphetamine Addiction, Part 5
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In the summer of 2019, Dr. Linda Dwoskin and her research team felt they were in a promising place in their decades-long search for a treatment for the 700,000 Americans...
Gaps in Substance Use Treatment Services for HIV Patients Around the Globe
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
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Significant increases in many kinds of drug use have been recorded since March
Cocaine Triggers Endocannabinoid Release Through a Novel Mechanism
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Cocaine can trigger release of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the ventral tegmental area of the midbrain in mice, and this may play a role in cocaine use disorder.