Amy Hauck Newman appointed to lead NIDA’s Intramural Research Program
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Dr. Newman officially began her new position at the NIDA IRP on November 22, 2020.
Latest from NIDA
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There is an alarming increase in deaths involving the stimulant drugs methamphetamine and cocaine.
Neighborhood conditions associated with children’s cognitive function
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NIH-funded research from ABCD Study finds association despite household income.
NIH study tests a comprehensive model intervention to reduce opioid overdose deaths in hard-hit communities
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COVID-19 brings challenges, learning opportunities
NIH-funded study links adolescent brain differences to increased waist circumference
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Finding from ABCD Study elucidates neural mechanisms that may underlie early weight gain
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People with SUDs may be particularly vulnerable to COVID-19 and its most adverse health outcomes
Narrative of Discovery: The Quest for a Medication to Treat Methamphetamine Addiction, Part 5
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In the summer of 2019, Dr. Linda Dwoskin and her research team felt they were in a promising place in their decades-long search for a treatment for the 700,000 Americans...
Gaps in Substance Use Treatment Services for HIV Patients Around the Globe
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
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Increases are among the largest in history of national study
Substance use disorders linked to COVID-19 susceptibility
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NIH research finds higher risk and worse outcomes for those with addiction
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Significant increases in many kinds of drug use have been recorded since March
Cocaine Triggers Endocannabinoid Release Through a Novel Mechanism
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Cocaine can trigger release of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the ventral tegmental area of the midbrain in mice, and this may play a role in cocaine use disorder.
Prenatal Cannabis Exposure Alters Brain Reward Circuitry in Male Rats
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Prenatal cannabis exposure (PCE) increased sensitivity to THC in male rats, but not female rats, during pre-adolescence. PCE increased dopamine release in response to THC and altered the properties of...
Research at the Intersection of HIV with Substance Use Disorders amidst the COVID-19 Pandemic
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We are prioritizing research into how the coexisting crises of COVID-19, HIV, and substance use, including the opioid crisis, combine to create a disastrous storm, taking lives and overtaxing America’s...
Two Different Brain Regions Are Linked With Nicotine Addiction Severity and Nicotine Withdrawal
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Activity in the striatum of people who smoke changed less in response to positive feedback/reward than in nonsmokers; this effect was more pronounced with greater addiction severity. Activity of the...
Treating Substance Use Disorders Can Reduce HIV Burden in U.S. Cities
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Concerted efforts and substantial investments in HIV prevention and care in the United States have resulted in considerable reduction in new diagnoses and death since the mid-1990s. To identify best...
NIDA Seeks Public Input for Our 2021-2025 Strategic Plan
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NIDA has begun drafting its strategic plan for 2021-2025, and to best inform that process, we are seeking input from the public and the scientific community.
Parents’ Marijuana Use May Increase Children’s Risk of Marijuana Use and Favorable Views of Marijuana
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This study found that children’s risk of marijuana and alcohol use and attitudes toward marijuana were influenced by their parents’ marijuana use pattern over time.
Clues to Regulating HIV-1 Viral Gene Expression
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
NIDA Researchers Adapt Their Projects to Study COVID-19
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The U.S. is now facing two intersecting health crises, the ongoing opioid overdose epidemic and the COVID-19 pandemic. Regrettably, each has the potential to exacerbate the effects of the other.
E-cigarette use associated with risk of relapse among former cigarette smokers
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This study has shown that among former smokers, use of electronic nicotine delivery systems (ENDS), including e-cigarettes and other e-products, is associated with increased chance of cigarette smoking relapse.
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We know that science itself is at its best when it is most inclusive, and humans are best when we embrace diversity. Conversations about systemic racial inequalities can be uncomfortable...
Researchers Identify Rare Gene Variants Associated With Smoking and Alcohol Use
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International research teams analyzed several hundred thousand samples from 17 whole-exome sequencing studies to identify rare gene variants associated with smoking and alcohol use. They identified rare variants in 117...
Shape shifters: The dynamic role of GCPRs in drug discovery
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the...
Expression of a Gene in the Brain Links Nicotine Addiction to Diabetes
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Rats with a disrupted transcription factor 7-like 2 (Tcf7l2) gene in the medial habenula showed markedly greater nicotine intake than control rats. Reduced Tcf7l2 expression in the medial habenula reduced...
NIDA launches drug education booklet series for middle school students
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The National Institute on Drug Abuse (NIDA) has launched a redesigned series of booklets geared towards educating middle school students about substance use. The Mind Matters series consists of nine...
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Healthcare already has effective tools including medications for opioid and alcohol use disorder, but they are not being utilized widely enough. One important reason is the stigma that surrounds people...
Learning how to disrupt cocaine’s effects on the brain
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular...
Landmark study of adolescent brain development renews for additional seven years
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With nearly $290M of new funding for seven years to research institutions around the country, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development (ABCD)...
Dopamine found to play unexpected role in cocaine withdrawal
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This study has linked cocaine withdrawal to altered gene expression in a brain region affected by addiction.