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Enabling collaborative, rapid advancements is the promise of open science. This kind of pivotal shift in research is particularly significant for the NIH HEAL Initiative®’s goal to urgently accelerate discovery of treatments for pain and opioid use disorders. In collaboration with the HEAL Connections team, this month’s Fresh FAIR webinar will highlight the importance of open science through examples of how sharing results and data can positively impact communities and spur further research discovery. Dr. Jessica Mazerik will kick off with an introduction to open science, followed by lightning talks from Dr. Sarah Woods and Dr. Rachel Wightman detailing their experiences reusing or synthesizing data to inform “on the ground” work, decisions, and policies. HEAL Stewards’ Liezl Mae Fos and HEAL Connections’ Jennifer Cook will then describe how each team helps investigators practice open science, both within and beyond the HEAL Data Ecosystem. The webinar will conclude with a live Question & Answer session.