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NIDA has begun drafting its strategic plan for 2021-2025, and to best inform that process, we are seeking input from the public and the scientific community.
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This study found that children’s risk of marijuana and alcohol use and attitudes toward marijuana were influenced by their parents’ marijuana use pattern over time.
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
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The U.S. is now facing two intersecting health crises, the ongoing opioid overdose epidemic and the COVID-19 pandemic. Regrettably, each has the potential to exacerbate the effects of the other.
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This study has shown that among former smokers, use of electronic nicotine delivery systems (ENDS), including e-cigarettes and other e-products, is associated with increased chance of cigarette smoking relapse.
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We know that science itself is at its best when it is most inclusive, and humans are best when we embrace diversity. Conversations about systemic racial inequalities can be uncomfortable...
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International research teams analyzed several hundred thousand samples from 17 whole-exome sequencing studies to identify rare gene variants associated with smoking and alcohol use. They identified rare variants in 117...
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the...
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Rats with a disrupted transcription factor 7-like 2 (Tcf7l2) gene in the medial habenula showed markedly greater nicotine intake than control rats. Reduced Tcf7l2 expression in the medial habenula reduced...
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Healthcare already has effective tools including medications for opioid and alcohol use disorder, but they are not being utilized widely enough. One important reason is the stigma that surrounds people...
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular...
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Mice genetically engineered to lack mu opioid receptors in the medial habenula were less sensitive to the unpleasant effects of the opioid antagonist naloxone and showed fewer naloxone-induced withdrawal symptoms.
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As people across the U.S. and the rest of the world contend with coronavirus disease 2019 (COVID-19), the research community should be alert to the possibility that it could hit...
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About 1 in 20 patients treated for a nonfatal opioid overdose in an emergency department died within 1 year of their visit, many within 2 days. Two-thirds of these deaths...
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This week, March 30 through April 5, 2020, is the 10th National Drug and Alcohol Facts Week (NDAFW), a yearly observance organized by NIDA in partnership with the National Institute...
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In this study, both rats and humans learned to predict differently flavored rewards in parallel choice tasks, showing that dopamine neurons are carrying much more information than previously thought.
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The degree of connectivity of a neuronal network in the rat brain before nicotine exposure can help predict nicotine dependence severity after nicotine exposure as well as reversal of dependence...
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This rodent study offers the first mechanistic explanation for the protective effect of social interaction related to incubation of craving, showing for the first time the role of a specific...
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Today, NIDA issued a Request for Information (RFI) from the research community and any other interested parties regarding the establishment of a standard unit dose of THC in order to...
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The serotonin 2C receptor agonist lorcaserin reduced reinstatement of drug-seeking behavior in response to heroin or cocaine in a nonhuman primate model of relapse.
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Most common mental disorders, from depression and anxiety to PTSD, are associated with disturbed sleep, and substance use disorders are no exception. The relationship may be complex and bidirectional: Substance...
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People's decisions to use e-cigarettes, as well as perceptions about associated risks, are influenced by the e-cigarettes' nicotine levels and available flavors. The influence of these characteristics on decision-making and...
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In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related...
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Computational modeling by NIDA scientists suggests the possible use of adenosine A2A receptor antagonists to counteract the adverse effects of cannabinoids.
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This study found that HIV-1 could be eliminated in mice using a combination of two antiviral technologies—long-acting viral reservoir—targeted antiretroviral therapy and CRISPR/Cas-9 gene editing. HIV was undetectable in 9...
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An analysis of Medicaid records shows that less than one-third of youths treated for a nonfatal opioid overdose received timely follow-up treatment, and only 1 in 54 youths received recommended...