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As our communities, healthcare systems, and government agencies join in the effort to reverse the epidemic of opioid overdoses and solve the opioid crisis, it is not enough to focus...
Latest from NIDA
Nicotine and Cannabis Have Offsetting Effects on Resting Brain Connectivity
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This research: Adds to research showing that nicotine and cannabis have interactive effects on brain structure and function. Suggests that specialized treatment interventions may be appropriate for people who use...
Study finds increased cannabis use during pregnancy
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Cannabis use more than doubled among pregnant women in the United States during the period 2002-2017.
Remembering Two Neurophysiology Pioneers
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In the first half of 2019, we have lost two researchers whose work in neuronal functioning and signaling helped revolutionize our understanding not only of the neurobiology of drug use...
Cannabis Dependence Is Associated With Changes in Neural Circuitry That May Contribute to Psychopathology
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People with cannabis dependence have changes in neural circuitry in brain regions related to reward processing, habit formation, and psychopathology. These changes in neural circuitry may provide a useful marker...
Project to deter opioid tampering wins 2019 NIDA Addiction Science Award
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A 14-year-old’s innovative approach to prevent tampering and misuse of opioid pills won a first place Addiction Science Award at the 2019 Intel International Science and Engineering Fair (ISEF)—the world’s...
National Institute on Drug Abuse Intramural Research Program Holds Opioid Symposium
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The National Institute on Drug Abuse (NIDA) Intramural Research Program will hold a one-day symposium to summarize the most recent advances in opioid research.
Brief drug use disrupts learning mechanisms in the brain
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In a new animal study, scientists at NIDA’s Intramural Research Program have demonstrated that cocaine use profoundly disrupts these teaching signals.
Narrative of Discovery: The Quest for a Medication To Treat Methamphetamine Addiction, Part 4
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In 2017, Dr. Linda Dwoskin applied to NIDA's Grand Opportunity for Medications Development program for support to continue her quest to develop the first-ever medication to reduce craving and relapse...
The Brain and our Immune System: Working Together
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Growing evidence in animal studies documents bidirectional signaling between the brain and immune system in the development of behavioral and physical health problems.
Scientists identify brain circuits engaged in compulsive heroin use
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People addicted to heroin and other opioids experience withdrawal when they discontinue or no longer have access to these drugs. Scientists at NIDA’s Intramural Research Program (IRP) wanted to learn...
How People with Substance Use Disorders (SUDs) Can Lend a Needed Hand in Addiction Research
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One of the major challenges in health science today is that not enough patients participate in clinical trials and other studies. Without volunteers willing and able to participate in studies...
Opioid Dose Variability Associated with Overdose
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A new study funded by the National Institute on Drug Abuse found that high dose variability increases the odds for an opioid overdose independent of dose alone.
Research Links Adolescent Substance Use to Adult Brain Volumes
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This research: Revealed associations between nicotine, alcohol, and marijuana use during two periods of adolescence and smaller gray matter volume in two brain areas at age 25. Supports a hypothesis...
Cues give clues in relapse prevention
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Scientists at NIDA's intramural research labs in Baltimore, Maryland have shown that discriminative stimuli can control the incubation of drug craving, even in the absence of conditioned stimuli.
Methadone Maintenance Treatment During Incarceration Has Long-Term Benefits
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This study reported: Prisoners who received methadone maintenance treatment (MMT) during incarceration were more likely than prisoners who did not receive MMT to engage in the treatment after being released...
FDA Special Announcement: Reports of Seizures After Using Nicotine Vaping Devices
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The FDA has become aware that some people who use e-cigarettes have experienced seizures, with most reports involving youth or young adult users.
Interim Buprenorphine Alleviates Psychiatric Symptoms in Waitlisted OUD Patients
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This study reported: Interim treatment with buprenorphine significantly improved the psychiatric symptoms of people awaiting comprehensive treatment for opioid use disorder (OUD). Buprenorphine treatment, even without concurrent psychosocial counseling, may...
Opioids without the risk of addiction?
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Investigators have found that the opioid-galanin receptor heteromers determine the different effects of methadone as compared to morphine and fentanyl, showing methadone with a weaker ability to activate the dopaminergic...
Dr. Jack Stein appointed NIDA Chief of Staff
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Dr. Nora Volkow, Director of the National Institute on Drug Abuse (NIDA), has appointed Jack B. Stein, Ph.D., to be the NIDA Chief of Staff, a newly created position to...
Opioid Overdose Reversal News: FDA-approved naloxone devices produce substantially higher blood levels of naloxone than improvised nasal spray
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A new study looked at how well the FDA-approved nasal spray and autoinjector compared to the improvised nasal devices, which are not FDA-approved.
The Genius of Chemogenetics
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Some NIDA-funded scientists have just published findings in the journal Science showing the development of a new, groundbreaking chemogenetics technology for modulating brain function in a remote, precise and ultra-sensitive...
Serotonin Unexpectedly Regulates Expression of Brain Genes
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The brain chemical serotonin can regulate expression of genes within neurons in a very unexpected way, as described in a NIDA-funded paper just published in the journal Nature.
The brain in pain
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NIDA-funded researchers identified a critical role for an internal brain opioid network called the dynorphin-kappa opioid receptor (KOR) system.
Prenatal and Early Childhood Brain Development: The HEALthy Brain and Child Development Study
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The NIH HEAL (Helping to End Addiction Long-term) initiative is helping to fund an ambitious research project called the HEALthy Brain and Child Development (HBCD) study. This study, which will...
Transcription Factor E2F3a Mediates Cocaine’s Effects on Gene Expression and Addiction-Related Behaviors
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NIDA-supported researchers have shown that increased levels of a single protein in the brain's reward center are indispensable for producing some of cocaine's addiction-like effects in animals. Their findings highlight...
Monthly buprenorphine injections effective for opioid use disorders
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A newly published study suggests the long-acting buprenorphine formulation BUP-XR is more effective than placebo in helping patients struggling with addiction to opioids. BUP-XR is a monthly extended-release injection.
New toolkit for genomic editing holds promise for addiction research
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The scientific world has advanced immeasurably by the science of DNA and genetics. Manipulating gene expression to change the way that cells such as neurons function has helped scientists create...
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This research shows: An experimental compound with a dual action at two opioid receptors may provide powerful pain relief without many of opioids' harmful side effects. The compound may also...
Disruption of Serotonin Contributes to Cocaine’s Effects
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This research: Traced the effects of cocaine-induced disruption of serotonin regulation in the ventral pallidum and orbitofrontal cortex. Suggests that these effects may contribute to drug-seeking and cocaine-associated cognitive impairments...