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In this international trial: Researchers demonstrated the effectiveness of an integrated intervention designed to help people who inject drugs and have HIV overcome obstacles to health care. Participants who received...
Latest from NIDA
New findings related to cell functions and calcium deficiency; may impact substance use disorders
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A new paper just published in Cell Reports describes, for the first time, a novel pathological mechanism that may contribute to a variety of disease states.
Stopping marijuana use improves memory
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A new study suggests that one month of abstinence from cannabis improves working memory in adolescents and young adults, with most of the improvement happening in the first week.
Cocaine-Induced Increase in an Immune Protein Promotes Addiction Behaviors in Mice
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This research found that: Cocaine produces a portion of its rewarding effects by increasing levels of granulocyte-colony stimulating factor (G-CSF) in the brain’s reward center. Treatments that prevent G-CSF signaling...
NIDA-NIAAA 2018 Mini-Convention: Frontiers in Addiction Research
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The National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), both part of the National Institutes of Health, will host a one-day mini...
In Memoriam—Herbert Kleber
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With the passing of Herbert Kleber on October 5, the field of addiction research has lost a true giant—one of its biggest thinkers as well as one of the most...
Compound identified as possible medication target for cocaine use disorder
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NIH-funded scientists have now identified a compound that shows promise in reducing self-administration of cocaine in mice.
Research suggests benzodiazepine use is high while use disorder rates are low
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A recent analysis suggests that benzodiazepine use disorders are relatively rare among the adults who use benzodiazepine medications, even if they are misusing them.
Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards
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This research suggests that: Mindfulness-Oriented Recovery Enhancement (MORE) reduces opioid misuse among chronic pain patients. MORE shifts patients' attention away from drug cues and toward cues for natural rewards. Dr...
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Medication is a crucial part of treating addiction—but by itself, a pill or an injection may not be sufficient. Social support has long been known to be an important factor...
Study shows impact of social interactions on addictive behavior
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A new study published in Nature Neuroscience finds that social interactions can have a profound effect on behaviors related to addiction, and on the brain’s response to drug-associated cues.
Switching to Reduced-Nicotine Cigarettes May Aid in Quitting Smoking
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This research suggests that: Smokers who switch to cigarettes with very low nicotine content may experience mild and transient increases in some withdrawal symptoms. Cigarettes with reduced nicotine will be...
Brain ensembles that tune on or off to social exploration
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An international team of scientists led by NIDA utilized miniature fluorescence microscopes to record calcium activities from hundreds of excitatory neurons in the mPFC in the brains of mice, while...
New opioid treatment resources for emergency department clinicians
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The National Institute on Drug Abuse (NIDA) today announced the availability of informational resources for clinicians interested in initiating buprenorphine treatment in emergency department settings.
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Nicotine does not produce the kind of euphoria or impairment that many other drugs like opioids and marijuana do. People do not get high from smoking cigarettes or vaping. Yet...
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The public health emergency of opioid misuse and addiction affects millions of Americans and requires innovative scientific solutions. Today, during “National Prescription Opioid and Heroin Awareness Week,” we are sharing...
How Cocaine Cues Get Planted in the Brain
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This research found that: An epigenetic mechanism underlies the powerful cocaine–environment associations that promote relapse. The mechanism may be instrumental in all drug reward–based learning. A NIDA-sponsored study sheds light...
Daily use of marijuana among non-college young adults at all time high
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The National Institute on Drug Abuse (NIDA) announced that the latest Monitoring the Future (MTF) survey results on substance use trends as teens transition to adulthood are now available online...
Immediate switch to low levels of nicotine in cigarettes more effective than a gradual reduction
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The FDA is considering a regulatory policy to reduce the levels of nicotine in combustible cigarettes to minimally addictive levels.
Intervention increases use of Medication for both HIV/AIDS and Substance Use Disorders
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A vanguard study with people who inject drugs provides evidence that a specific flexible, scalable intervention increases reported use of both antiretroviral therapy for HIV/AIDS (ART) and medication therapy for...
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Ample evidence shows methadone and buprenorphine reduce overdose deaths, prevent the spread of diseases like HIV, and enable people to take back their lives, but there are restrictions on who...
A look at drug craving
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Studies using animal models of addiction have shown that drug seeking progressively increases after drug self-administration stops, which is a phenomenon called incubation of drug craving.
Proven Prevention Program Aims To Adapt for Native Americans
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This research showed: A survey that is a key tool in the Communities That Care prevention system is largely valid in Native American communities. Adjusting the survey to incorporate culturally...
E-Cigs linked to heart attacks
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An analysis of health data concludes that e-cigarette use, adjusted for smoking conventional cigarettes and other risk factors, is associated with increased risk of myocardial infarction, which is commonly known...
Mindfulness training and substance use treatment
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A NIDA-funded study showed that a mindful awareness training program is associated with improved outcomes for women seeking treatment for substance use disorders.
How cannabis use disorder affects working memory
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Using imaging technologies, NIDA-funded scientists peered into the brains of people with cannabis use disorder to test their working memory, compared to a control group.
A New Tool for Investigating HIV in the Brain
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In this research: Researchers developed a tool that enables them to closely monitor HIV activity in key brain cells. The tool may accelerate the development of treatments for HIV in...
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Some teens's marijuana use has been linked to disrupted communication between two key regions in the brain's reward circuitry at age 20. Disrupted communication between the regions was associated with...
E-Cigarettes Promote Smoking Progression in Youth and Depress Quitting Among Adults
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E-cigarettes are not an effective tool to reduce combustible-cigarette smoking, two NIDA-supported studies indicate.
Pregnant women in Appalachia face barriers to opioid treatment
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A NIDA-funded study has discovered that pregnant women in Appalachia face barriers to receiving medication-assisted treatment for opioid use disorders, from both insurers and providers.