Adolescent outcomes of Post-operative opioid Exposure (APEX) (NIH HEAL Initiative)

Funded by the NIH HEAL Initiative®

Opioid overdose is an unabated US public health crisis and a leading cause of injury-related death in the United States, resulting in more than 110,000 deaths in 2022. The effect on adolescents undergoing painful surgery is of particular concern because any use of prescribed opioids during adolescence is independently associated with both overdose and future OUD, and nearly 90% of opioid overdose deaths in children occur among teenagers. This project aims to recruit 10,000 adolescents undergoing major surgery and follow them for one year post operatively. We will collect comprehensive data on preoperative factors, pain outcomes, behavioral issues, social determinants of health and medication use, with the goal of evaluating the composition of factors that are markers of future opioid use.

CTN Protocol ID: 

Principal Investigator(s)

Joseph Cravero, M.D.

Professor, Chair, Department of Anesthesiology, Critical Care, and Pain Medicine
Boston Children’s Hospital
Harvard Medical School

300 Longwood Avenue
Boston, MA 02115
United States

Sharon Levy, M.D., M.P.H.

Medical Director, Adolescent Substance Abuse Program; Assistant Professor of Pediatrics
Boston Children's Hospital
Harvard Medical School
Division of Developmental Medicine

300 Longwood Avenue, 3114
Boston, MA 02115
United States