Research Studies

Protocol Number Status
Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD CTN-0150 Development
Trajectories of Secondary Outcomes in CTN Trials CTN-0149 Development
Cocaine Craving and Use Outcomes Secondary Analysis of a Randomized Study to Test the Safety and Effectiveness of Buprenorphine in the Presence of Naltrexone for the Treatment of Cocaine Dependence CTN-0148 Active
Building Opioid recovery support Networks to engage and retain young adults in Medication for Opioid Use Disorder (BOND) (NIH HEAL Initiative) CTN-0147 Development
Adolescent outcomes of Post-operative opioid Exposure (APEX) (NIH HEAL Initiative) CTN-0146 Development
Standard versus High Dose ED-Initiated Buprenorphine Induction (NIH HEAL Initiative) CTN-0145 Development
Better Together: Integrating MOUD in African American Community Settings (NIH HEAL Initiative) CTN-0144 Development
Social Determinants of Health (SDOH); Needs and Consequences Associated with Substance Use Disorders CTN-0143 Active
Towards Personalized Medicine in Medication for Opioid Use Disorder (MOUD): Analyses of Veterans Health Administration Data to Delineate Patient Characteristics Associated with Treatment Outcomes and Successful MOUD Discontinuation CTN-0142 Development
Health Insurance Instability and Mortality among Patients Receiving Buprenorphine Treatment for Opioid Use Disorder: Linkage of the Prescription Opioid Registry with the National Death Index CTN-0141 Active
Cannabis Use among Pregnant Women with Polysubstance Use and Psychiatric Problems CTN-0140 Completed
Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care) (NIH HEAL Initiative) CTN-0139 Development
Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool CTN-0138 Development
Multi-Level Stigma Intervention to Improve Access to Substance Use Care with Prescribing Providers in Mental Health Settings CTN-0137 Development
Medication for Opioid Use Disorder, Predictability of Retention vs. Attrition CTN-0136 Active
Buprenorphine Treatment Engagement and Induction Problems Among Individuals Using Fentanyl CTN-0135 Active
Buprenorphine-Precipitated Withdrawal Hotspots and Correlates CTN-0134 Completed
Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (NIH HEAL Initiative) CTN-0133 Active
Ketamine for Methamphetamine Use Disorder Study CTN-0132 Development
Methadone or Enhanced Buprenorphine to Address Retention Among Patients not Optimally Benefitting from Office-based Buprenorphine – a Hybrid Effectiveness/Implementation Trial CTN-0131 Development
Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) CTN-0130 Completed
The Great Plains Initiative CTN-0129 Active
Adherence and Feasibility of Wearable Technologies and Ecological Momentary Assessment to Assess Autonomic Function and Negative Affect in Opioid Use Disorder (NIH HEAL Initiative) CTN-0128 Active
Engaging African American Faith-based leaders in a Substance Use Learning Collaborative CTN-0127 Active
Longitudinal Follow-up of Individuals with Opioid Use Disorder CTN-0126 Active
Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine CTN-0125 Active
Assessment and Design of a Cost-Effective Collaborative MOUD Delivery System CTN-0124 Completed
Facebook intervention for preventing opioid relapse among American Indian Women CTN-0123 Active
Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex CTN-0122 Active
Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders (SUD) among Hospitalized Patients CTN-0121 Development
R-Mist: Remote Methadone Ingestion Surveillance Trial CTN-0120 Development
Impact of Social Distancing Measures, Expansion of Telemedicine for Buprenorphine Prescribing, and Health Insurance Payor on Access to Buprenorphine During the COVID-19 Pandemic CTN-0119 Completed
Examining the COVID-19 Public Health Emergency on Policy, Substance Use Disorder, Treatment and Resilience among American Indian and Alaska Native Communities CTN-0118 Active
The Impact of COVID-19 Pandemic on Substance Use Treatment Services CTN-0117 Completed
Pharmacist-Integrated Model of Medication Treatment for Opioid Use Disorder CTN-0116 Active
Developing an Intervention to Address Intersecting Prescription Opioid and Chronic Pain Stigma in Cancer Survivors (NIH HEAL Initiative) CTN-0115 Completed
Drug Repurposing for Cocaine Use Disorder (CUD) Using a Combined Strategy of Artificial Intelligence (AI)-Based Prediction and Retrospective Clinical Corroboration CTN-0114 Completed
Validating a DSM-5 Substance Use Disorder (SUD) Symptom Checklist in EHR Data from a Large Primary Care Sample to Support Future Pragmatic Trials and Chronic Care Management of SUDs in Primary Care CTN-0113 Completed
Optimal Policies to Improve Methadone Maintenance Adherence Long-Term (OPTIMMAL) CTN-0112 Completed
COVID-19 and Substance Misuse Case Identification using Data Science: A Retrospective Cohort Study CTN-0111 Completed
Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB)(NIH HEAL Initiative) CTN-0110 Active
Innovative Development of Research Engagement Manual (I-DREM): Strategies to Enhance Recruitment and Retention of Black Individuals in CTN-0109 CURB-2 CTN-0109-A-1 Active
Randomized, Placebo-Controlled Trial of Injectable Naltrexone and Monthly Injectable Buprenorphine for Cocaine Use Disorder (CURB-2) CTN-0109 Active
Transcranial Magnetic Stimulation for the Treatment of Methamphetamine/Cocaine Use Disorder CTN-0108 Active
Peer Intervention to Link Overdose survivors to Treatment (PILOT) (NIH HEAL Initiative) CTN-0107 Active
Derivation and Validation of New Measurement-Based Care Tools Derived from the Brief Addiction Monitor (NIH HEAL Initiative) CTN-0106 Completed
Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative) CTN-0105 Completed
Healthcare Provider Stigma Related to the Opioid Use Epidemic and its Impact on Patient Treatment and Clinical Management CTN-0104 Completed
Expanding Clinical Research Training on Implementing the Evidence-based Hub and Spoke Model of Medication-Assisted Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0103 Completed
Rural Expansion of Medication Treatment for Opioid Use Disorder: Randomized Controlled Pilot Trial of Extended-release Buprenorphine vs. Sublingual Buprenorphine-naloxone in Rural Settings (NIH HEAL Initiative) CTN-0102-XR Development
Rural Expansion of Medication Treatment for Opioid Use Disorder: Electronic Health Record Data Collection and Analysis (NIH HEAL Initiative) CTN-0102-C Completed
COVID Impact on Rural Expansion of Medication Treatment for Opioid Use Disorder CTN-0102-A Completed
Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative) CTN-0102 Completed
Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative) CTN-0101 Active
Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative) CTN-0100 Active
Barriers and Facilitators to Engaging in Addiction Treatment among Black, Latino, and non-Latino White Patients Receiving ED-initiated Buprenorphine Treatment (NIH HEAL Initiative) CTN-0099-A-1 Active
Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative) CTN-0099 Active
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative) CTN-0098 Active
Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative) CTN-0097 Completed
National Medication-Assisted Treatment Survey of Substance Use Disorder Programs Serving American Indian and Alaska Native People (NIH HEAL Initiative) CTN-0096-A-1 Active
Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative) CTN-0096 Active
Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians (NIH HEAL Initiative) CTN-0095-A-2 Completed
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder (NIH HEAL Initiative) CTN-0095-A-1 Completed
Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative) CTN-0095 Active
Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative) CTN-0094 Completed
Validation of a Community Pharmacy-based Prescription Drug Monitoring Program Risk Screening Tool (PHARMSCREEN) (NIH HEAL Initiative) CTN-0093 Completed
Preventing and Identifying Opioid Use Disorder using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative) CTN-0091 Completed
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative) CTN-0090 Completed
Integrating Nurse Practitioner Buprenorphine Waiver Training into Graduate Nursing Curriculum (NIH HEAL Initiative) CTN-0089 Completed
Better Together. Community Partnership for a Healthy Community Free from Addiction CTN-0088 Completed
A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative) CTN-0087 Completed
Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative) CTN-0086 Completed
Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative) CTN-0085 Completed
Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder (D-TECT) (NIH HEAL Initiative) CTN-0084-A-2 Completed
Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality (NIH HEAL Initiative) CTN-0084-A-1 Completed
Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative) CTN-0084 Completed
Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services CTN-0083 Completed
Vaccine Readiness in People Who Use Substances In Community STI Clinics and Substance Use Intervention or Harm Reduction Programs In Eight Higher HIV Incidence Southeastern Cities CTN-0082-A-1 Completed
Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and MSM-Centered Community Based Organizations (CBOs) CTN-0082 Completed
Emergency Medicine Opioid Data Infrastructure: Key Venue to Address Opioid Morbidity and Mortality (Project CODE PRO – Capturing Opioid Use Disorder Electronically and Patient Reported Outcomes) CTN-0081 Completed
Improved Messaging Strategies for MOUD for Underserved Populations of Pregnant and Postpartum Individuals with OUD CTN-0080-A-3 Development
Promoting Research with Mothers receiving OUD Treatment; a focus on Equity (PRoMOTE) CTN-0080-A-2 Development
Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant People with Opioid Use Disorder (SUCCESS STUDY) CTN-0080-A-1 Development
Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (NIH HEAL Initiative) CTN-0080 Active
Ancillary Study of the Adoption and Sustainability of ED-Initiated Buprenorphine (NIH Heal Initiative) CTN-0079-A-1 Completed
Emergency Department Connection to Care with Buprenorphine for Opioid Use Disorder (ED-CONNECT) CTN-0079 Completed
Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities CTN-0078 Completed
Medical Cannabis Use among Primary Care Patients: Using Electronic Health Records to Study Large Populations CTN-0077 Completed
Clinical decision support for Opioid use disorders in Medical settings: Pilot Usability Testing in an EMR (COMPUTE) CTN-0076 Completed
Pharmacy Screening and Collaborative Opioid Use Disorder Care (Pharm-OUD-Care) CTN-0075 Completed
Primary Care Opioid Use Disorders Treatment Trial Economic Analysis Study (NIH HEAL Initiative) CTN-0074-A-1 Completed
Primary Care Opioid Use Disorders Treatment Trial CTN-0074 Completed