| Pilot Development and Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine |
CTN-0156 |
Development |
| Low-threshold Buprenorphine Treatment at Syringe Services Programs: a Type I Hybrid Effectiveness-implementation Trial |
CTN-0155 |
Development |
| EMS initiated Buprenorphine for Opioid Use Disorder |
CTN-0154 |
Development |
| Effects of Semaglutide and Tirzepatide on Incidence and Outcomes of Stimulant Use Disorders and Opioid Use Disorder in Real-world Populations: Target Trial Emulation Using Patient Electronic Health Records (GLP-SUD). |
CTN-0153 |
Development |
| Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the treatment of opioid use disorder: A pragmatic, multi-site, double-blind, Randomized, placebo-controlled, trial (TAB). |
CTN-0152 |
Development |
| Toward Pharmacy-Led Value Based Care Model for Buprenorphine Initiation and Management (PharmValue): Development of a Scalable Pharmacist-Led Collaborative Practice Agreement for Medication for Opioid Use Disorder |
CTN-0151 |
Development |
| Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD |
CTN-0150 |
Active |
| Trajectories of Secondary Outcomes in CTN Trials |
CTN-0149 |
Development |
| Cocaine Craving and Use Outcomes Secondary Analysis of a Randomized Study to Test the Safety and Effectiveness of Buprenorphine in the Presence of Naltrexone for the Treatment of Cocaine Dependence |
CTN-0148 |
Completed |
| Adolescent outcomes of Post-operative opioid Exposure (APEX) (NIH HEAL Initiative) |
CTN-0146 |
Development |
| Standard versus High Dose ED-Initiated Buprenorphine Induction (NIH HEAL Initiative) |
CTN-0145 |
Development |
| Better Together: Integrating MOUD in African American Community Settings (NIH HEAL Initiative) |
CTN-0144 |
Development |
| Social Determinants of Health (SDOH); Needs and Consequences Associated with Substance Use Disorders |
CTN-0143 |
Completed |
| Towards Personalized Medicine in Medication for Opioid Use Disorder (MOUD): Analyses of Veterans Health Administration Data to Delineate Patient Characteristics Associated with Treatment Outcomes and Successful MOUD Discontinuation |
CTN-0142 |
Active |
| Health Insurance Instability and Mortality among Patients Receiving Buprenorphine Treatment for Opioid Use Disorder: Linkage of the Prescription Opioid Registry with the National Death Index |
CTN-0141 |
Completed |
| Cannabis Use among Pregnant Women with Polysubstance Use and Psychiatric Problems |
CTN-0140 |
Completed |
| Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care) (NIH HEAL Initiative) |
CTN-0139 |
Active |
| Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool |
CTN-0138 |
Active |
| Multi-Level Stigma Intervention to Improve Access to Substance Use Care with Prescribing Providers in Mental Health Settings |
CTN-0137 |
Completed |
| Medication for Opioid Use Disorder, Predictability of Retention vs. Attrition |
CTN-0136 |
Completed |
| Buprenorphine Treatment Engagement and Induction Problems Among Individuals Using Fentanyl |
CTN-0135 |
Completed |
| Buprenorphine-Precipitated Withdrawal Hotspots and Correlates |
CTN-0134 |
Completed |
| Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (NIH HEAL Initiative) |
CTN-0133 |
Completed |
| Ketamine for Methamphetamine Use Disorder Study |
CTN-0132 |
Active |
| Office-Based Methadone versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment – A Randomized Pragmatic Hybrid Effectiveness/Implementation Trial |
CTN-0131 |
Active |
| Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) |
CTN-0130 |
Completed |
| The Great Plains Initiative |
CTN-0129 |
Completed |
| Adherence and Feasibility of Wearable Technologies and Ecological Momentary Assessment to Assess Autonomic Function and Negative Affect in Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0128 |
Completed |
| Engaging African American Faith-based leaders in a Substance Use Learning Collaborative |
CTN-0127 |
Active |
| Longitudinal Follow-up of Individuals with Opioid Use Disorder |
CTN-0126 |
Active |
| Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine |
CTN-0125 |
Completed |
| Assessment and Design of a Cost-Effective Collaborative MOUD Delivery System |
CTN-0124 |
Completed |
| Facebook intervention for preventing opioid relapse among American Indian Women |
CTN-0123 |
Active |
| Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex |
CTN-0122 |
Completed |
| Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders (SUD) among Hospitalized Patients |
CTN-0121 |
Active |
| R-Mist: Remote Methadone Ingestion Surveillance Trial |
CTN-0120 |
Development |
| Impact of Social Distancing Measures, Expansion of Telemedicine for Buprenorphine Prescribing, and Health Insurance Payor on Access to Buprenorphine During the COVID-19 Pandemic |
CTN-0119 |
Completed |
| Examining the COVID-19 Public Health Emergency on Policy, Substance Use Disorder, Treatment and Resilience among American Indian and Alaska Native Communities |
CTN-0118 |
Completed |
| The Impact of COVID-19 Pandemic on Substance Use Treatment Services |
CTN-0117 |
Completed |
| Pharmacist-Integrated Model of Medication Treatment for Opioid Use Disorder |
CTN-0116 |
Completed |
| Developing an Intervention to Address Intersecting Prescription Opioid and Chronic Pain Stigma in Cancer Survivors (NIH HEAL Initiative) |
CTN-0115 |
Completed |
| Drug Repurposing for Cocaine Use Disorder (CUD) Using a Combined Strategy of Artificial Intelligence (AI)-Based Prediction and Retrospective Clinical Corroboration |
CTN-0114 |
Completed |
| Validating a DSM-5 Substance Use Disorder (SUD) Symptom Checklist in EHR Data from a Large Primary Care Sample to Support Future Pragmatic Trials and Chronic Care Management of SUDs in Primary Care |
CTN-0113 |
Completed |
| Optimal Policies to Improve Methadone Maintenance Adherence Long-Term (OPTIMMAL) |
CTN-0112 |
Completed |
| COVID-19 and Substance Misuse Case Identification using Data Science: A Retrospective Cohort Study |
CTN-0111 |
Completed |
| Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB)(NIH HEAL Initiative) |
CTN-0110 |
Completed |
| Innovative Development of Research Engagement Manual (I-DREM): Strategies to Enhance Recruitment and Retention of Black Individuals in CTN-0109 CURB-2 |
CTN-0109-A-1 |
Active |
| Randomized, Placebo-Controlled Trial of Injectable Naltrexone and Monthly Injectable Buprenorphine for Cocaine Use Disorder (CURB-2) |
CTN-0109 |
Active |
| Transcranial Magnetic Stimulation for the Treatment of Methamphetamine/Cocaine Use Disorder |
CTN-0108 |
Completed |
| Peer Intervention to Link Overdose survivors to Treatment (PILOT) (NIH HEAL Initiative) |
CTN-0107 |
Completed |
| Derivation and Validation of New Measurement-Based Care Tools Derived from the Brief Addiction Monitor (NIH HEAL Initiative) |
CTN-0106 |
Completed |
| Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative) |
CTN-0105 |
Completed |
| Healthcare Provider Stigma Related to the Opioid Use Epidemic and its Impact on Patient Treatment and Clinical Management |
CTN-0104 |
Completed |
| Expanding Clinical Research Training on Implementing the Evidence-based Hub and Spoke Model of Medication-Assisted Treatment for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0103 |
Completed |
| Rural Expansion of Medication Treatment for Opioid Use Disorder: Randomized Controlled Pilot Trial of Extended-release Buprenorphine vs. Sublingual Buprenorphine-naloxone in Rural Settings (NIH HEAL Initiative) |
CTN-0102-XR |
Active |
| Rural Expansion of Medication Treatment for Opioid Use Disorder: Electronic Health Record Data Collection and Analysis (NIH HEAL Initiative) |
CTN-0102-C |
Completed |
| COVID Impact on Rural Expansion of Medication Treatment for Opioid Use Disorder |
CTN-0102-A |
Completed |
| Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0102 |
Completed |
| Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative) |
CTN-0101 |
Completed |
| Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative) |
CTN-0100 |
Active |
| Barriers and Facilitators to Engaging in Addiction Treatment among Black, Latino, and non-Latino White Patients Receiving ED-initiated Buprenorphine Treatment (NIH HEAL Initiative) |
CTN-0099-A-1 |
Completed |
| Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative) |
CTN-0099 |
Completed |
| Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative) |
CTN-0098 |
Active |
| Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0097 |
Completed |
| National Medication-Assisted Treatment Survey of Substance Use Disorder Programs Serving American Indian and Alaska Native People (NIH HEAL Initiative) |
CTN-0096-A-1 |
Completed |
| Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative) |
CTN-0096 |
Completed |
| Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians (NIH HEAL Initiative) |
CTN-0095-A-2 |
Completed |
| Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0095-A-1 |
Completed |
| Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative) |
CTN-0095 |
Completed |
| Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative) |
CTN-0094 |
Completed |
| Validation of a Community Pharmacy-based Prescription Drug Monitoring Program Risk Screening Tool (PHARMSCREEN) (NIH HEAL Initiative) |
CTN-0093 |
Completed |
| Preventing and Identifying Opioid Use Disorder using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative) |
CTN-0091 |
Completed |
| Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative) |
CTN-0090 |
Completed |
| Integrating Nurse Practitioner Buprenorphine Waiver Training into Graduate Nursing Curriculum (NIH HEAL Initiative) |
CTN-0089 |
Completed |
| Better Together. Community Partnership for a Healthy Community Free from Addiction |
CTN-0088 |
Completed |
| A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative) |
CTN-0087 |
Completed |
| Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0086 |
Completed |
| Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative) |
CTN-0085 |
Completed |
| Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder (D-TECT) (NIH HEAL Initiative) |
CTN-0084-A-2 |
Completed |
| Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality (NIH HEAL Initiative) |
CTN-0084-A-1 |
Completed |
| Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative) |
CTN-0084 |
Completed |
| Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services |
CTN-0083 |
Completed |
| Vaccine Readiness in People Who Use Substances In Community STI Clinics and Substance Use Intervention or Harm Reduction Programs In Eight Higher HIV Incidence Southeastern Cities |
CTN-0082-A-1 |
Completed |
| Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and MSM-Centered Community Based Organizations (CBOs) |
CTN-0082 |
Completed |
| Emergency Medicine Opioid Data Infrastructure: Key Venue to Address Opioid Morbidity and Mortality (Project CODE PRO – Capturing Opioid Use Disorder Electronically and Patient Reported Outcomes) |
CTN-0081 |
Completed |
| Improved Messaging Strategies for MOUD for Underserved Populations of Pregnant and Postpartum Individuals with OUD |
CTN-0080-A-3 |
Active |
| Promoting Research with Mothers receiving OUD Treatment; a focus on Equity (PRoMOTE) |
CTN-0080-A-2 |
Active |
| Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant People with Opioid Use Disorder (SUCCESS STUDY) |
CTN-0080-A-1 |
Active |
| Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (NIH HEAL Initiative) |
CTN-0080 |
Active |
| Ancillary Study of the Adoption and Sustainability of ED-Initiated Buprenorphine (NIH Heal Initiative) |
CTN-0079-A-1 |
Completed |
| Emergency Department Connection to Care with Buprenorphine for Opioid Use Disorder (ED-CONNECT) |
CTN-0079 |
Completed |
| Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities |
CTN-0078 |
Completed |
| Medical Cannabis Use among Primary Care Patients: Using Electronic Health Records to Study Large Populations |
CTN-0077 |
Completed |
| Clinical decision support for Opioid use disorders in Medical settings: Pilot Usability Testing in an EMR (COMPUTE) |
CTN-0076 |
Completed |
| Pharmacy Screening and Collaborative Opioid Use Disorder Care (Pharm-OUD-Care) |
CTN-0075 |
Completed |
| Primary Care Opioid Use Disorders Treatment Trial Economic Analysis Study (NIH HEAL Initiative) |
CTN-0074-A-1 |
Completed |
| Primary Care Opioid Use Disorders Treatment Trial |
CTN-0074 |
Completed |
