Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care) (NIH HEAL Initiative)

Funded by the NIH HEAL Initiative®

Although primary care settings can be an ideal context for identifying unhealthy polysubstance use and initiating treatment, in practice few patients are identified, and effective, feasible, evidence-based treatment models are lacking. To address this gap, study investigators plan to test a collaborative care (CC) intervention for patients with complex needs and heightened overdose risk, such as that posed by concurrent use of opioids with sedatives, stimulants, or alcohol. Study aims include 1) testing the effectiveness of the CC intervention for reducing days of polysubstance use over 6 months (primary outcome), and 12 months (secondary outcome) and 2) examining the impact of the CC intervention on the following secondary outcomes: problems related to substance use, SUD severity, overdose risk behavior and events, health-related quality of life, mental health symptoms, receipt of addiction treatment, primary care engagement, and acute care utilization.

CTN Protocol ID: 

Principal Investigator(s)

Jennifer McNeely, M.D., M.S.

Associate Professor
New York University Grossman School of Medicine

180 Madison Avenue, 17th Floor
New York, NY 10016
United States

Jane Liebschutz, M.D., M.P.H., FACP

Chief, Division of General Internal Medicine
University of Pittsburgh School of Medicine
UPMC Health System

200 Lothrop Street, Suite 933W
Pittsburgh, PA 15213
United States