Trajectories of Secondary Outcomes in CTN Trials

This secondary analysis study aims to employ a group based latent class approach to characterize trajectories of subgroups on person-centered secondary outcomes (indicators) across time in CTN trials. These indicators include mental health (i.e., depression and anxiety), quality of life, withdrawal, craving, and pain.  The study also aims to a) conduct multinomial logistic regression to identify patient risk factors associated with latent class trajectory group membership and b) employ survival analyses to examine differences on return to use outcomes (relapse) based upon posterior probabilities of most-likely class membership.

CTN Protocol ID: 

Principal Investigator(s)

Noel Vest, Ph.D.

Assistant Professor
Boston University School of Public Health
Community Health Sciences

801 Massachusetts Ave
Boston , MA 02118
United States

Todd Korthuis, M.D., M.P.H.

Associate Professor of Medicine
Oregon Health & Science University
Department of Public Health & Preventive Medicine

3181 Southwest Sam Jackson Park Road, L475
Portland, OR 97239-3098
United States

Sterling McPherson, Ph.D.

Washington State University
Elson S. Floyd College of Medicine
Department of Community and Behavioral Health

412 E Spokane Falls Boulevard
Spokane, WA 99202
United States