Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative)

Funded by the NIH HEAL Initiative®

This study will evaluate implementation of emergency department (ED)-initiated BUP in a large number of sites; compare extended release (XR)-BUP with sublingual (SL) BUP in ED patients with untreated OUD; and develop and validate electronic health record phenotypes of opioid-related illnesses to characterize ED visits, enhance active disease surveillance, and better identify patients eligible for study inclusion.

CTN Protocol ID: 
ClinicalTrials.gov ID: 

Principal Investigator(s)

Gail D'Onofrio, M.D., M.S.

Professor of Emergency Medicine
Yale University School of Medicine
Chair, Department of Emergency Medicine

464 Congress Avenue
Suite 260
New Haven, CT 06519
United States

David Fiellin, M.D.

Professor of Medicine and Public Health
Yale University School of Medicine

333 Cedar Street
P.O. Box 208056
New Haven, CT 06520
United States