NIDA Health Disparities Research and Funding Opportunities

The alarming state of health disparities among vulnerable populations in the United States is a serious public health concern and has garnered wide-spread attention from the United States government leadership (e.g., HHS, Congress), the NIH, and the public, especially with the current COVID-19 pandemic.

Addressing health disparities will require a multi-level approach so it is important to know what has been done, what is currently being done, and what research still needs to be done in this area. The purpose of this webpage is to house active funding opportunity announcements as well as list other NIDA initiatives focused on reducing health disparities and improving the health of vulnerable populations. This list of FOAs will be updated periodically so that we are displaying current FOAs, but for the most current list of FOAs, please see the NIH Guide. Below we have provided a brief definition of a health disparity and populations affected by health disparities.

What is a health disparity?

health disparity is defined as “a particular type of health difference that is closely linked with social, economic, and/or environmental disadvantage. Health disparities adversely affect groups of people who have systematically experienced greater obstacles to health based on their racial or ethnic group; religion; socioeconomic status; gender; age; mental health; cognitive, sensory, or physical disability; sexual orientation or gender identity; geographic location; or other characteristics historically linked to discrimination or exclusion” (U.S. Department of Health and Human Services and Healthy People 2020).

What populations are adversely affected by health disparities?

NIH-designated U.S. health disparity populations include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. See NOT-OD-15-089.

References:

NIDA Health Disparities Funding Opportunity Announcements 

NIH HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 Clinical Trials Optional)
In April 2018, the National Institutes of Health (NIH) launched the Helping to End Addiction Long-termSMInitiative or HEAL InitiativeSM, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. Through this initiative the National Institute on Drug Abuse, in partnership with other NIH Institutes, Centers, and Offices, requests applications for studies designed to develop and test multi-level interventions to prevent opioid misuse, opioid use disorder, and co-occurring conditions by intervening on social determinants of health. This initiative aims to build an evidence base for multi-level interventions that target malleable factors and conditions affecting the social context. Applications must seek to reduce health inequities in a U.S. population or population subgroup affected by the opioid crisis by studying the effects of a theory driven, multi-level intervention on the prevention of opioid misuse/opioid use disorder and co-occurring conditions. Such conditions could include mental health conditions and/or suicide, and may also include other substance use and substance use-related outcomes.
FOA: RFA-DA-22-036 Expiration Date: March 03, 2022


HEAL Initiative: Planning Grants for Efficacy or Effectiveness Trials of Recovery Support Services for Individuals Treated with Medications for Opioid Use Disorder (R34 Clinical Trial Optional)
This Funding Opportunity Announcement is to support pilot and preliminary research to prepare for rigorous clinical efficacy or effectiveness trials of recovery support services for individuals who take or have taken medications for the treatment of opioid use disorder. Relevant trials may test a wide range of services where rigorous evidence of efficacy and effectiveness is needed including peer-based recovery support, recovery community centers, active recovery communities, recovery residences, education-based recovery support services, continuing care models, recovery support services to meet the needs of specific minority health populations, recovery support services to meet the needs of specific health disparities populations, combinations of these recovery support services, or others proposed by applicants. 
FOA: RFA-DA-22-034 Expiration Date: March 11, 2022


HEAL Initiative: Research Networks for the Study of Recovery Support Services for Persons Treated with Medications for Opioid Use Disorder (R24 Clinical Trial Optional)
This Funding Opportunity Announcement is to support applications providing infrastructure support to advance the development of efficacy and/or effectiveness research on recovery support services for those who take or have taken medications for the treatment of opioid use disorder. The infrastructure support will facilitate multi-stakeholder (including researchers and students, payors, providers, persons in recovery) research networks through activities such as meetings, conferences, small-scale pilots, data development work, short-term educational opportunities (such as intensive workshops, summer institutes, or visiting scholar programs), dissemination to encourage growth and development of specified priority areas, and building research resources.
FOA: RFA-DA-22-043 Expiration Date: March 11, 2022


HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
The purpose of this FOA is to solicit applications to develop, test, and implement novel, culturally-appropriate pain interventions and/or adapt, test and evaluate efficacy and effectiveness of existing pain interventions, in populations that disproportionately experience negative health outcomes. Desired outcomes of these interventions include reduction of pain and pain-related symptoms, and improvement in overall health outcomes, including function and quality of life. Interventions that target populations that experience health disparities with chronic pain in addition to at least one comorbid condition (OUD, mental health disorders and/or chronic health conditions) are of the highest priority.
FOA: RFA-NS-22-037 Expiration Date: March 23, 2022


Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center (UM2 Clinical Trial Optional)
This Funding Opportunity Announcement invites applications to participate in a research program cooperative agreement to support the Adolescent Medicine Trials Network for HIV/AIDS Interventions. The Network will have the capacity to develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide and vaccine trials in youth ages 13-24 years at-risk for HIV and living with HIV, with a focus on the inclusion of minors. Investigators with innovative approaches to address the public health issues facing adolescents are encouraged to apply.
FOA: RFA-HD-23-020 Expiration Date: April 01, 2022


Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)
This Funding Opportunity Announcement invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing and ultimately eliminating health disparities in one or more NIH-defined population groups who experience health disparities. Appropriate technologies should be effective, affordable, and culturally acceptable.
FOA: RFA-MD-22-004 Expiration Date: April 5, 2022


PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH) invites eligible United States small businesses to submit Small Business Technology Transfer (STTR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA).
FOA: PA-21-261 Expiration Date: April 6, 2022
FOA: 
PA-21-262 Expiration Date: April 6, 2022


PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), invites eligible United States small businesses to submit Small Business Innovation Research (SBIR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH and CDC awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA).
FOA: PA-21-260 Expiration Date: April 6, 2022
FOA: 
PA-21-259 Expiration Date: April 6, 2022


Notice of Special Interest (NOSI): Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship
The participating Institutes and Centers are inviting applications to support administrative supplements to existing awards of scientists who are outstanding mentors and who have demonstrated compelling commitments and contributions to enhancing diversity, equity, inclusion, and accessibility (DEIA) in the biomedical sciences. Excellent mentorship and superior training are critical to the development of exceptional future scientists. This administrative supplement recognizes the crucial role great mentors play in the development of future leaders in the scientific research enterprise.
NOTICE: NOT-OD-22-057 Expiration Date: April 8, 2022


Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations (R01 Clinical Trial Optional)
This funding opportunity announcement invites applications that seek to understand strategies to reduce disparities in the uptake of evidence-based screening (e.g. screening recommendations proven to be effective based on rigorous systematic review of scientific evidence by authoritative committees) across the adult lifespan. Research supported by this initiative should enhance the screening process related to use: (1) in diverse populations, (2) in diverse clinical and community settings, and/or (3) with traditional, non-traditional and/or allied health care providers.
FOA: PA-18-932 Expiration Date: May 8, 2022


Advancing communication strategies to support future HIV vaccine use (R01 Clinical Trial Optional)
Advancing communication strategies to support future HIV vaccine use (R21 Clinical Trial Optional)

This Funding Opportunity Announcement invites applications for Research Project Grants (R21) that will advance novel health communication research designed to inform and support acceptance and uptake of future vaccines that protect against HIV. Research should focus on understanding key drivers for HIV vaccine communication success, communication strategies for engagement of communities placed at greatest risk for acquiring HIV, and/or mitigating the impact and reach of HIV vaccine misinformation. Research applications may leverage HIV vaccine analogs (e.g., COVID-19, HPV, HBV vaccines), so long as they have a primary focus on populations placed at risk for HIV, and/or healthcare settings and providers involved in HIV prevention delivery. Applications with preliminary data and/or those including longitudinal analysis, advanced modeling, or large-scale clinical trials should consider using the R01 mechanism. Applications proposing to conduct exploratory, novel studies that break new ground, extend previous discoveries in new directions or result in novel techniques, models, or applications should consider the R21 mechanism.
FOA: RFA-MH-22-170 Expiration Date: May 11, 2022
FOA: 
RFA-MH-22-171 Expiration Date: May 11, 2022


Centers for AIDS Research (P30  Clinical Trial Not Allowed
The purpose of this Funding Opportunity Announcement is to invite applications for the Centers for AIDS Research (CFAR) program to provide administrative and shared research support to enhance HIV/AIDS research. CFARs provide core facilities, expertise, resources, and services not readily obtained otherwise through more traditional funding mechanisms. The program emphasizes interdisciplinary collaboration across all areas of HIV/AIDS research. 
FOA: PAR-20-106 Expiration Date: July 29, 2022


Developmental Centers for AIDS Research (P30 Clinical Trial Not Allowed)
The purpose of this Funding Opportunity Announcement is to invite applications for the Developmental Centers for AIDS Research (D-CFAR) program to provide administrative and shared research support to enhance HIV/AIDS research. D-CFARs provide core facilities, expertise, resources, and services not readily obtained otherwise through more traditional funding mechanisms.  Additionally, D-CFARs provide support to assist investigators in the development of a competitive standard CFAR. The program emphasizes interdisciplinary collaboration across all areas of HIV/AIDS research. 
FOA: PAR-20-107 Expiration Date: July 29, 2022


Mechanisms and Consequences of Sleep Disparities in the U.S. (R01 - Clinical Trial Not Allowed)
The purpose of this Funding Opportunity Announcement is to promote research to understand the underlying mechanisms of sleep deficiencies among U.S. populations that experience health disparities and how sleep deficiencies may lead to disparities in health outcomes.
FOA: PAR-20-164 Expiration Date: July 15, 2022


Getting To Zero: Understanding HIV Viral Suppression and Transmission in the United States (R01 Clinical Trial Optional
The purpose of this funding opportunity announcement is to support grants to improve understanding of viral suppression and HIV transmission in the U.S. using population-level epidemiology, novel tools from data science approaches and m/eHealth, and implementation science research. Data generated through this research will be used to inform and evaluate context-specific HIV control strategies towards the goal of ending the HIV epidemic in the U.S.
FOA: PAR-20-036 Expiration Date: September 8, 2022


Notice of NIDA's Participation in NOT- MD-22-006 "Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities"
The purpose of this NOSI is to solicit research to: 1) evaluate community-engaged interventions (e.g., expand reach, increase access, address psychosocial barriers) to facilitate vaccination uptake in clinical and community contexts; 2) evaluate organizational, local, state, and federal policies and initiatives that mitigate or exacerbate disparities in vaccine access, uptake, and series completion, and 3) understand and address barriers to increasing reach, access, and uptake of vaccinations among populations who experience health disparities.
Notice: NOT-MD-22-006 Expiration Date: January 8, 2023


Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities
This Notice of Special Interest highlights the need for research on strategies, and interventions to address vaccine hesitancy, uptake, and implementation among populations who experience health disparities in the US and its territories. Research is needed to understand and address misinformation, distrust, and hesitancy regarding uptake of vaccines (e.g., SARS-CoV-2, pneumococcal, influenza, hepatitis B, human papilloma virus (HPV)) among adults in the United States and territories, especially in populations at increased risk for morbidity and mortality due to long-standing systemic health and social inequities and chronic medical conditions.
Notice: NOT-MD-22-006 Expiration Date: January 8, 2023 


Music and Health: Understanding And Developing Music Medicine (R01 Clinical Trial Optional)
This Funding Opportunity Announcement is intended to: (1) increase our understanding of how music affects the brain when it is used therapeutically and/or (2) use that knowledge to better develop evidence-based music interventions to enhance health or treat specific diseases and disorders.
FOA: PAR-21-100 Expiration Date: February 6, 2023


Tobacco Regulatory Science (R01 Clinical Trial Optional)
The purpose of this Funding Opportunity Announcement is to invite R01 applications to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration Center for Tobacco Products.
RFA: RFA-OD-21-002 Expiration Date: February 15, 2023


Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards
The overarching goal of this pilot program is to enhance the retention of investigators facing critical life events who are transitioning to the first renewal of their first independent research project grant award or to a second new NIH research project grant award. Retention at the first renewal or continuous NIH research project grant support is crucial for sustaining both the ongoing research NIH has made an investment in and for retaining diversity in the biomedical research workforce. This program supports “at-risk” investigators as identified in the NIH Next Generation Researchers Initiative (see https://grants.nih.gov/ngri.htm).
NOTICE: NOT-OD-20-055 Expiration Date: March 06, 2023


Health Services Research on Minority Health and Health Disparities (R01- Clinical Trial Optional)
The purpose of this funding opportunity announcement is to encourage innovative health services research that can directly and demonstrably contribute to the improvement of minority health and/or the reduction of health disparities at the health care system-level as well as within clinical settings.
FOA: PAR-20-310 Expiration Date: March 28, 2023


Notice of Special Interest (NOSI): Simulation Modeling and Systems Science to Address Health Disparities 
The purpose of this Notice of Special Interest is to support investigative and collaborative research focused on developing and evaluating simulation modeling and systems science to understand and address minority health and health disparities.
Notice: NOT-MD-20-025 Expiration Date: May 08, 2023


Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 Clinical Trials Not Allowed)
This funding opportunity announcement (FOA) invites basic and/or methodological research projects that seek to illuminate or measure independent and interdependent health-related effects within dyads. For the purpose of this FOA, a dyad is a unit of two individuals whose interactions and influences on one another are nested within larger social contexts and networks. Both animal and human subjects research projects are welcome. Types of projects submitted under this FOA include but are not limited to, observational studies involving humans, or existing/synthesized datasets studies.
FOA: PAR-21-281 Expiration Date: May 08, 2023


Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 - Basic Experimental Studies with Humans)
This funding opportunity announcement (FOA) invites basic and/or methodological research projects that illuminate and/or measure independent and interdependent health-related effects within dyads across relationships and settings. For the purpose of this FOA, a dyad is a unit of two individuals whose interactions and influences on one another are nested within larger social contexts and networks. Dyads are social relationships that extend beyond the individual and have strong bidirectional influences on physical and mental health. For the purpose of this FOA, independent effects are those effects that affect each member of the dyad individually (i.e., by nature of being part of the dyad), whereas interdependent effects are those that affect one member of the dyad contingent upon the other member of the dyad (i.e., not only because the individual is part of a dyad but also because being part of the dyad has an effect on the other individual within the dyad as well).
FOA: PAR-21-280 Expiration Date: May 08, 2023


Research Project Grant (Parent R01 Clinical Trial Required)
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
FOA: PA-20-183 Expiration Date: May 08, 2023


NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
FOA: PA-20-185 Expiration Date: May 08, 2023


Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.”
FOA: PA-20-184 Expiration Date: May 08, 2023


Substance Use/Substance Use Disorder Dissertation Research Award (R36 - Clinical Trials Optional)
The goal of this FOA is to support doctoral candidates from a variety of academic disciplines for up to two years for the completion of the doctoral dissertation research project. This award will facilitate the entry of promising new investigators into the field of substance use/substance use disorder (SU(D) research, enhancing the pool of highly talented SU(D) researchers. Applications are particularly encouraged from those who can contribute to diversifying the research workforce as described in the Notice of NIH's Interest in Diversity (NOT-OD-20-031).
FOA: PA-20-208 Expiration Date: May 08, 2023


Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention hereby notify Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) holding specific types of research grants (activity codes listed above) that funds are available for administrative supplements to enhance the diversity of the research workforce by recruiting and supporting students, postdoctorates, and eligible investigators from diverse backgrounds, including those from groups that have been shown to be underrepresented in health-related research. This supplement opportunity is also available to PD(s)/PI(s) of research grants who are or become disabled and need additional support to accommodate their disability in order to continue to work on the research project.  Administrative supplements must support work within the scope of the original project.
FOA: PA-21-071 Expiration Date: May 08, 2023


Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)

The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.
FOA: PA-20-206 Expiration Date: May 08, 2023
FOA: 
PA-20-205 Expiration Date: May 08, 2023


Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)

The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and “protected time” (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances.
FOA: PA-20-176 Expiration Date: May 08, 2023
FOA: 
PA-20-190 Expiration Date: May 08, 2023


Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.
FOA: PA-20-202 Expiration Date: May 08, 2023
FOA: 
PA-20-203 Expiration Date: May 08, 2023


Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required)
The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. This Parent Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.”  These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research.  Types of studies that should be submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind.
FOA: PA-20-201 Expiration Date: May 08, 2023


NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)

The purpose of the NIH Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers.
FOA: PA-20-187 Expiration Date: May 08, 2023
FOA: 
PA-20-188 Expiration Date: May 08, 2023


NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required)
The purpose of the NIH Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers.

This Parent Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212  as “prospective basic science studies involving human participants.”  These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research.  Types of studies that should be submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind.
FOA: PA-20-189 Expiration Date: May 08, 2023


Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
The National Institutes of Health hereby notify recipient organizations holding specific types of NIH grants, listed in the full Funding Opportunity Announcement (FOA), that applications for change of recipient organization status, often referred to in this announcement as Successor-In-Interest, may be submitted to this FOA. Applications for change of recipient organization status are considered prior approval requests (as described in Section 8.1.2.8 of the NIH Grants Policy Statement) and will be routed for consideration directly to the Grants Management Specialist named in the current award.
Notice: PA-20-275 Expiration Date: July 24, 2023


New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial Required)
New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Required)

The purpose of this funding opportunity announcement is to support the testing of enhanced models of care that optimally integrate HIV, addiction, and primary care services.  NIDA is interested in research that addresses gaps related to the delivery of comprehensive, integrated health services to include the full continuum of HIV/AIDS services, addiction prevention and treatment services, and primary care services, with a goal of improving the coordination of care, and improving health outcomes related to HIV and SUD in the US for populations who are at high risk.
FOA: PAR-20-273 Expiration Date: August 12, 2023
FOA: 
PAR-20-274 Expiration Date: August 12, 2023


Long-Term Effects of Disasters on Health Care Systems Serving Health Disparity Populations (R01- Clinical Trial Optional
The overarching goal of this funding opportunity announcement is to invite robust investigative and collaborative research focused on understanding the long-term effects of disasters on health disparity populations and the health care systems that serve them, including the influence of risk factors or vulnerabilities of both the systems and the communities preceding the event(s).
FOA: PA-20-172 Expiration Date: September 8, 2023


Research to Improve Native American Health (R21 Clinical Trials Optional)
The purpose of this funding opportunity announcement is to support developmental/exploratory studies in preparation for health promotion, disease prevention, treatment, or treatment services research to improve health in Native American (NA) populations. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this announcement, culturally informed exploratory/developmental research is sought that builds upon community knowledge, resources, and resilience to provide foundational knowledge for future science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment.
FOA: PAR-20-214 Expiration Date: September 8, 2023


Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
SuRE is a research capacity building program designed to develop and sustain research excellence in U.S. higher education institutions that receive limited NIH research support and serve students from groups underrepresented in biomedical research NOT-OD-20-031 with an emphasis on providing students with research opportunities and enriching the research environment at the applicant institutions. The purpose of SuRE awards is to provide research grant support for faculty investigators who have prior experience in leading externally-funded, independent research but are not currently funded by any NIH Research Project Grants with the exception of SuRE or SuRE-First awards.
FOA: PAR-21-169 Expiration Date: September 08, 2023


Identifying Innovative Mechanisms or Interventions that Target Multimorbidity and Its Consequences (R01 Clinical Trial Optional)
This Funding Opportunity Announcement (FOA) invites applications that seek to support the identification of shared mechanisms and development of innovative interventions to address multimorbidity or multiple chronic conditions (MCCs) and its consequences. Intervention research supported by this initiative should be designed to study: (1) mechanisms or pathways that prevent MCCs, including the identification of early biomarkers, behavioral pathways, and individual and contextual risk factors and interactions that contribute to the development of common MCCs; (2) targeted therapies and management, including self-management, of MCCs to delay progression and prevent onset of new diseases; and (3) innovative health care partnership models for managing or treating MCCs.
FOA: PAR-20-180 Expiration Date: September 08, 2023


Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity (R01 Clinical Trial Optional)
This Funding Opportunity Announcement invites applications that seek to improve the availability, quality, and utility of data and measures that capture multimorbidity or multiple chronic conditions (MCCs) and the methods for analyzing multimorbidity data. Research supported by this initiative should be designed to discover, develop, and/or evaluate MCC measures/tools that reflect the longitudinality and life course diversity of multimorbidity.
FOA: PAR-20-179 Expiration Date: September 08, 2023


Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
The purpose of this funding opportunity announcement is to support research on interventions to improve health in Native American (NA) populations. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment.
FOA: PAR-20-238 Expiration Date: September 8, 2023


Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
The National Institutes of Health (NIH) hereby notify Program Directors/Principal Investigators (PD(s)/PI(s)) holding specific types of NIH research grants listed in the full Funding Opportunity Announcement (FOA) that funds may be available for administrative supplements to meet increased costs that are within the scope of the approved award, but were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted.
FOA: PA-20-272 Expiration Date: October 08, 2023


BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)
This Funding Opportunity Announcement (FOA) from the NIH Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This FOA encourages research project grant applications from multi-disciplinary teams focused on key ethical issues associated with BRAIN Initiative supported research areas.
RFA: RFA-MH-21-205 Expiration Date: October 12, 2023


Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Use and Addiction Scientists (R25 Clinical Trials Not Allowed)
The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research 
FOA: PAR-20-236 Expiration Date: November 16, 2023


Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R34 Clinical Trial Optional)
The purpose of this FOA is to support the development, adaptation, and pilot testing of implementation strategies to achieve system-level adoption of evidence-based interventions, guidelines, or practices to improve the delivery, quality, and sustainability of prevention or treatment services for substance use disorders.
FOA: PA-21-203 Expiration Date: November 16, 2023


NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
The purpose of the NIH Research Conference Grant (R13) is to support high quality conferences that are relevant to the public health and to the scientific mission of the participating Institutes and Centers.  Applications for NIH support of conferences and scientific meetings must include a plan to enhance diversity in all aspects of conference planning and implementation. Also, it is expected that organizers of NIH-supported conferences employ strategies that seek to prevent or mitigate the effects of discrimination and harassment, sexual and otherwise.
FOA: PA-21-151 Expiration Date: January 8, 2024


 Support for Research Excellence – First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed) 
SuRE is a research capacity building program designed to develop and sustain research excellence in U.S. higher education institutions that receive limited NIH research support and serve students from groups underrepresented in biomedical research with an emphasis on providing students with research opportunities and enriching the research environment at the applicant institutions. The purpose of SuRE-First awards is to support research grants for faculty investigators who have not had prior independent external research grants.
FOA: PAR-21-173 Expiration Date: January 8, 2024


Innovation Corps (I-Corps™) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)
Through this 'I-Corps™ at NIH' program Funding Opportunity Announcement (FOA), the National Institutes of Health and Center for Disease Control and Prevention (CDC) provide administrative supplement awards to active SBIR (NIH and CDC) and STTR Phase I (NIH only) recipients. The I-Corps at NIH program is focused on educating researchers and technologists on how to translate technologies from the lab into the marketplace. I-Corps enables and accelerates the transformation of invention to impact patients.
FOA: PAR-22-073 Expiration Date: February 03, 2024


Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Required)
Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)

The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students, and enhancing the research environment at applicant institutions.
FOA: PAR-21-154 Expiration Date: May 08, 2024
FOA: PAR-21-155 Expiration Date: May 08, 2024


Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)
The purpose of this funding opportunity announcement is to support creative educational activities with a primary focus on research experiences for high school students, undergraduate students, and/or science teachers during the summer academic break.
FOA: PAR-21-168 Expiration Date: May 8, 2024


Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 - Clinical Trial Optional)
This Funding Opportunity Announcement encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials. Relevant trials may test a wide range of approaches, including interventions, practices, and policies designed to optimize access to, and the quality, effectiveness, affordability and utilization of drug, tobacco, or alcohol use disorder treatments and related services, as well as services for comorbid medical and mental disorder conditions. 
FOA: PA-21-180 Expiration Date: May 8, 2024 


Notice of Special Interest (NOSI): Social, Behavioral, and Economic Impact of COVID-19 in Underserved and Vulnerable Populations
The purpose of this Notice is to 1) emphasize the roles and impacts of interventions, particularly those under the umbrella of digital health, as well as community-engaged and multi-level interventions in healthcare settings to address access, reach, delivery, engagement, effectiveness, scalability, and sustainability of services that are utilized during and following the pandemic, and 2) encourage the leveraging of existing large-scale data sources with broad population coverage to improve prediction of various mitigation efforts (including vaccinations, masking, and physical distancing to inform the public health response) on transmission reduction and on social and economic impacts, and assess the downstream health and healthcare access effects, with an emphasis on underserved and vulnerable populations. Additionally, the use of large-scale data sources to study the indirect health impacts of the pandemic and subsequent social and economic changes is needed to understand the costs and benefits of various COVID-19 mitigation strategies.
Notice: NOT-MH-21-330 Expiration Date: September 08, 2024


AIDS-Science Track Award for Research Transition (R03 Clinical Trial Optional)
This funding opportunity announcement (FOA) seeks to facilitate the entry of both newly independent and early career investigators to the area of drug use and use disorder research and HIV/AIDS. This FOA, the AIDS-Science Track Award for Research Transition (A-START), encourages Small Research Grant (R03) applications to support research projects on drug use and/or use disorder and HIV/AIDS that can be carried out in a short period of time with limited resources. This FOA welcomes applications integrating substance use and/or substance use disorder (SUD) and HIV/AIDS across all areas of research supported by NIDA.
Notice: PAS-21-270 Expiration Date: September 08, 2024


Notice of Special Interest: Public Policy Effects on Alcohol-, Cannabis-, Tobacco-, and Other Drug-Related Behaviors and Outcomes
This announcement encourages applications to conduct research on the effects of public policies on health-related behaviors and outcomes associated with alcohol, cannabis, tobacco, prescription drugs, and other substances. The purpose of the Notice is to advance understanding of how public policy may serve as a tool for improving public health and welfare through its effects on behaviors and outcomes pertaining to alcohol and other drugs. 
Notice: NOT-AA-21-028 Expiration Date: September 08, 2024


The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional)
The purpose of this Funding Opportunity Announcement is to support innovative population-based research that can contribute to identifying and characterizing pathways and mechanisms through which work or occupation influences health outcomes and health status among populations with health and/or health care disparities, and how work functions as a social determinant of health.
FOA: PAR-21-275 Expiration Date: September 8, 2024


Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01 - Clinical Trials Optional) This initiative will support innovative, collaborative, and multi-disciplinary research designed to study the effective adaptation, integration, and implementation of recommended guidelines of care of persons with multiple chronic conditions from populations that experience health disparities. Projects would be expected to involve more than one component and/or more than one level of influence within existing or newly proposed health care models. The goal of this initiative is attainment of optimal treatment and health outcomes goals to advance health care towards health equity.
FOA: PAR-22-092 Expiration Date: September 8, 2024


Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
The National Institutes of Health hereby notify Small Business Concerns holding Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants that funds are available for administrative supplements to enhance the diversity of the research and entrepreneurial workforce by recruiting and supporting students, postdoctorates, and eligible investigators from diverse backgrounds, including those from groups that have been shown to be underrepresented in health-related research or in the SBIR and STTR programs.
FOA: PA-21-345 Expiration Date: September 10, 2024


Accelerating the Pace of Drug Abuse Research Using Existing Data (R01 Clinical Trial Optional)
Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of substance using behaviors (defined as alcohol, tobacco, prescription, and other substances) and related disorders, prevention of substance use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of substance using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of substance use disorder and HIV. Primary data collection is not allowed for applications in response to this FOA.
RFA: RFA-DA-22-037 Expiration Date: November 16, 2024
RFA: 
RFA-DA-22-038 Expiration Date: November 16, 2024


Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required)
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
The purpose of the Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for health professional, undergraduate and graduate students and enhancing the research environment at applicant institutions.
FOA: PAR-21-357 Expiration Date: January 08, 2025
FOA: 
PAR-22-060 Expiration Date: January 08, 2025


Effectiveness of School-Based Health Centers to Advance Health Equity (R01 Clinical Trial Optional)
The purpose of this Funding Opportunity Announcement is to support research that investigates the effectiveness of school-based health centers as a health services care delivery model to address the needs of school-aged children from populations with health disparities (hence, underserved youth).
FOA: PAR-21-287 Expiration Date: January 8, 2025