NIDA Genetic Consortium Meetings & Abstracts


The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 23-24, 2024 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Registration and Meeting support information

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May 23 - Session 1 Concurrent Panels (9:30–10:45 a.m.) SCORCH Consortium: Single-cell Approaches to Define Intersections Between Substance Use Disorders and HIV Infection
Chair: Paul Kenny, Ph.D., Icahn School of Medicine at Mount Sinai
TimeFirst NameLast NameEmailAbstract Title
9:15 a.m. - 9:30 a.m.AlejandraBorjabadAlejandra.Borjabad@mssm.eduHIV infection enhances the addiction-related actions of opioids: Brain substrates and cellular mechanisms
9:30 a.m. - 9:45 of Single cell multiomic changes during chronic HIV infection and cocaine self-administration in mice
9:45 a.m. - 10:00 a.m.BrianHerbbherb@som.umaryland.eduComparative single-cell multi-omic atlases of molecular adaptations associated with substance use and HIV infections in the prefrontal cortex and nucleus accumbens of humans, non-human primates, and rodents
10:00 a.m. - 10:15 a.m.RaleighLinvillelinville@mit.eduCellular taxonomy of the human and mouse striatum defines novel neuronal subtypes in opioid and antipsychotic action
The ABCD Study - A Rich Resource for Genetic and Epigenetic Research on the Predictors of Substance Use
Kimberly LeBlanc, Ph.D., National Institute on Drug Abuse
Pamela Madden, Ph.D. Washington University in St. Louis.
TimeFirst NameLast NameEmailAbstract Title
9:15 a.m. - 9:30 a.m.RobertLoughnanrloughnan@ucsd.eduOpportunities and Challenges in Studying Genetic Risk for Substance Abuse in the ABCD Study
9:30 a.m. - 9:45 a.m.Hermine H.Maeshermine.maes@vcuhealth.orgEstimating twin heritability and environmental sources of variation in the ABCD Study.
9:45 a.m. - 10:00 a.m.JillRabinowitzjr1919@rutgers.eduAssociations of Neural and Genetic Characteristics with Substance Use Risk in the Adolescent Brain Cognitive Development Study
10:00 a.m. - 10:15 a.m.AlexanderHatoumashatoum@wustl.edu2.) Phenome Wide Association Study of Polygenic Risk Scores for Substance Use Disorders in The Adolescent Brain and Development Study
May 23 – Session 2 Concurrent Panels (1:45–3:00 p.m.) Leveraging the All of Us Biobank to Make Strides In Substance Use Disorder Genomics Research
Arpana Agrawal, Ph.D., Washington University in St. Louis
Daniel Jacobson, Ph.D., Oak Ridge National Laboratory
TimeFirst NameLast NameEmailAbstract Title
1:45 p.m. - 2:00 p.m.Janitza L.Montalvo-Ortizjanitza.montalvo-ortiz@yale.eduAccelerating psychiatric genetics research in Latin American populations: Consortia efforts and Novel findings
2:00 p.m. - 2:15 p.m.PeterBarrpeter.barr@downstate.eduThe impact of social and genetic risk factors on the onset of comorbid problems in persons with substance use disorders.
2:15 p.m. - 2:30 p.m.EmmaJohnsonemma.c.johnson@wustl.edu1.) Phenotypic and genomic relationships between chronic pain and substance use disorders in the All of Us biobank
2:30 p.m. - 2:45 p.m.RodneyGabrielragabriel@health.ucsd.eduPredicting Development of Opioid Use Disorder Among Chronic Pain Patients Using Genomics, Social, and Clinical Factors within the All of Us Research Dataset
Understanding the Role of NAc in Substance Use Disorder (SUD) Beyond the D1 and D2 Level
Yi Zhang, Ph.D., Boston Children's Hospital
Veronica Alvarez, Ph.D., National Institute of Mental Health
TimeFirst NameLast NameEmailAbstract Title
1:45 p.m. - 2:00 and characterizing neuron subtypes and circuits regulating SUD
2:00 p.m. - 2:15 p.m.Mary KayLobomklobo@som.umaryland.eduCell subtype transcriptional programs in cocaine intake and seeking behavior
2:15 p.m. - 2:30 p.m.Ana-ClaraBobadillaac.bobadilla@colostate.eduDifferential genetic expression within reward-specific ensembles in mice
2:30 p.m. - 2:45 p.m.Veronica A.Alvarezalvarezva@mail.nih.govTranscriptomic Landscape of Compulsive-like Alcohol Drinking
May 23 – Short Talk Session 1 (3:00–4:00 p.m.)
TimeFirst NameLast NameEmailAbstract Title
3:00 p.m. - 3:05 p.m.ElissaCheslerElissa.Chesler@jax.orgIntegrative mouse genetic analysis illuminates human GWAS of multiple substance use.
3:05 p.m. - 3:10 p.m.MichaelGarvingarvinmr@ornl.govGenetic Loci Associated with Cocaine Use Identified using Novel Approach to Detect Epistasis
3:10 p.m. - 3:15 p.m.VivekKumarVivek.Kumar@jax.orgForward genetic screen of the KOMP2/IMPC resource identifies addiction mutants
3:15 p.m. - 3:20 p.m.ZhanaDurenzduren@clemson.eduInferring gene regulatory networks from single cell multiome data using atlas-scale external data
3:20 p.m. - 3:25 p.m.JohnHernandezjohn_hernandez@brown.eduSingle nuclei transcriptomics of the Drosophila mushroom body
3:25 p.m. - 3:30 p.m.J SpencerHatfieldjshatfi@clemson.eduGenome-wide Association Analysis of Cocaine Preference in Drosophila
3:30 p.m. - 3:35 p.m.SergeiGrigoryevsag17@psu.eduCryo-electron tomography reveals the inner structure of nucleosome condensates in chromatin of epigenetically modified mouse retina
3:35 p.m. - 3:40 p.m.AndyChenandychen@iu.eduFunctional Screening of Regulatory Variants Combined with Genome-wide Association and Machine Learning Identifies Causal Regulatory Mechanisms Impacting Substance Use Disorders
3:40 p.m. - 3:45 p.m.ChenFuchen.fu@umassmed.eduAssociation between elevated markers of DNA damage and higher frequency of somatic mutations in neurons in opioid use disorder
3:45 p.m. - 3:50 p.m.OlivierGeorgeolgeorge@health.ucsd.eduIdentification of gene variants that predict cocaine addiction-like behaviors in heterogeneous stock rats
May 24 - Session 3 Concurrent Panels (9:05–10:20 a.m.) RNA-binding Proteins and Post-transcriptional Gene Regulation in Addiction Disorders
Duan Liu, Ph.D., Mayo Clinic
Yunlong Liu, Ph.D., Indiana University
TimeFirst NameLast NameEmailAbstract Title
9:35 a.m. - 9:50 a.m.YunlongLiuyunliu@iu.eduRoles of alternative splicing in alcohol use disorder
9:05 a.m. - 9:20 a.m.DuanLiuliu.duan@mayo.eduNeuron-specific RNA-binding Protein ELAVL2 and Post-transcriptional Gene Regulation in Substance Use Disorders
9:20 a.m. - 9:35 a.m.HuipingZhanghuipingz@bu.eduRNA N6-methyladenosine modifications in the mesolimbic dopamine system of subjects with alcohol use disorder
9:50 a.m. - 10:05 a.m.KatieRothamelkrothamel@health.ucsd.eduAdvancing RBP Research: Scalable Tools for Protein-RNA Interaction Analysis
Computational Approaches Analyzing Big Healthcare Data Using Machine Learning And Other Tools To Identify Genetic, Phenotypic Risk Factors And Potential Medication Treatments For Substance Use Disorders or Co-Occurring Mental Health Conditions
Udi Ghitza, Ph.D., National Institute on Drug Abuse
Susan Wright Ph.D., National Institute on Drug Abuse.
TimeFirst NameLast NameEmailAbstract Title
9:05 a.m. - 9:20 a.m.RongXurxx@case.eduRepurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses
9:20 a.m. - 9:35 a.m.RoyPerlisRPERLIS@mgh.harvard.eduUses and misuses of machine learning for electronic health records
9:35 a.m. - 9:50 a.m.AlexanderHatoumashatoum@wustl.edu3.) Machine learning Predictors of Substance Use disorder using Genetics Need Control for Ancestry
9:50 a.m. - 10:05 a.m.TravisMallardtmallard@mgh.harvard.eduCharacterizing the Genetic Architecture of Impulsivity and its Overlap with Substance Use and Psychopathology
May 24 – Session 4 Concurrent Panels (1:15–2:30 p.m.) Novel Methodologies to Untangle Transcriptional and Epigenetic Underpinnings of Substance Use Disorder.
Eric Nestler, M.D., Ph.D., Icahn School of Medicine at Mount Sinai
Ian Maze, Ph.D., Icahn School of Medicine at Mount Sinai
TimeFirst NameLast NameEmailAbstract Title
1:15 p.m. - 1:30 p.m.AlexanderSmithsmitaw@musc.eduA master regulator of opioid reward in ventral prefrontal cortex
1:30 p.m. - 1:45 p.m.TamaraMarkovictamara.markovic@mssm.eduModulating levels of ∆FOSB alters nucleus accumbens medium spiny neurons activity to salient stimuli.
1:45 p.m. - 2:00 p.m.SashaFultonslf2127@columbia.eduMulti-omic single-nucleus characterization of orbitofrontal cortex after cocaine self-administration
2:00 p.m. - 2:15 p.m.KristenMaynardKristen.maynard@libd.orgMulti-omic approaches for molecular mapping of reward circuitry in the human brain
Decoding the Web of Addiction: A Systems Biology and Network Analysis Perspective
Olivia Corradin, Ph.D., Massachusetts Institute of Technology
Sulggi Lee, M.D., Ph.D., University of California, San Francisco
TimeFirst NameLast NameEmailAbstract Title
1:15 p.m. - 1:30 p.m.Julia (Kate)Brynildsenjbryn@seas.upenn.eduGene coexpression patterns predict opiate-induced brain-state transitions
1:30 p.m. - 1:45 p.m.Ming-FenHoho.mingfen@mayo.eduSingle cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
1:45 p.m. - 2:00 p.m.SusanRibeirosusan.pereira.ribeiro@emory.eduMethamphetamine Use in People with HIV on Antiretroviral Therapy is Associated with Elevated Systemic Inflammation and HIV Reservoir Transcription
2:00 p.m. - 2:15 p.m.BoZhangbzhang29@wustl.eduMethamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats
May 24 – Short Talk Session 2 (4:00–5:00 p.m.)
TimeFirst NameLast NameEmailAbstract Title
4:00 p.m. - 4:05 p.m.RahulD'Mellodmello@ohsu.eduPrenatal THC Exposure Alters the Offspring Methylome, Neurodevelopment, and Emotional Behavior
4:05 p.m. - 4:10 p.m.AnnaLeonardanna.leonard@pennmedicine.upenn.eduAlternative splicing in a mouse model of Oprm1 A118G
4:10 p.m. - 4:15 p.m.Alice K.Minalice.min@mountsinai.orgGenetically Modified Human iPSC-Derived Microglia in a Chimeric Mouse Model for Studying CNS HIV-1 Infection and Drug Use
4:15 p.m. - 4:20 p.m.DongbingLaidlai@iu.eduGenome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations
4:20 p.m. - 4:25 p.m.NanaAmissahnanaamis@buffalo.eduGenome wide association studies in heterogeneous stock rats identify links between cue-reactivity and cocaine motivation.
4:25 p.m. - 4:30 p.m.JasonBubierJason.Bubier@jax.orgOne of these things is not like the others: Genetic Variation in Morphine and Fentanyl Response in Mice.
4:30 p.m. - 4:35 p.m.Drew D.Kiralydkiraly@wakehealth.eduGut-brain signaling as a modulator of brain chromatin structure and gene expression in models of substance use disorder.
4:35 p.m. - 4:40 p.m.Ying-XianPanyx.pan@rutgers.edu2.) Mitigating adverse side effects of clinically used mu opioids by targeting exon 7-associated splice variants of the mu opioid receptor gene, Oprm1, without altering mu opioid analgesia in pain management
May 23 – Poster Session A (10:45 a.m.–12:15 p.m.)
Poster NumberFirst NameLast NameEmailAbstract Title
1HannahAltonhannah.alton@nih.govRevisiting the cannabinoid-opioid interaction hypothesis using conditional CB1 and µ opioid receptor knockout mice
2Bradley E.Aouizeratbea4@nyu.eduPiercing the veil of how substance use negatively impacts comorbidities in HIV
3BabakBabanbbaban@augusta.eduEpigenetic effects on substance abuse through immune re-modelling
4Svitlana V.Bachsvitlana.bach@libd.orgMolecular profiling of the human nucleus accumbens with spatial and single nucleus resolution
5JaredBagleyjbagley@binghamton.eduPolygenic risk for extreme cocaine intake associates with larger dopaminergic responses to cocaine in the nucleus accumbens of BXD inbred mice
6LudmilaBakhirevalbakhireva@salud.unm.eduDiagnostic Utility of miRNA Signature in Umbilical Cord Blood for Identification of Severe Neonatal Opioid Withdrawal Syndrome
7Britahny M.Baskinb.baskin@northeastern.eduSpontaneously Hypertensive Rat substrains and the offspring of reciprocal F2 crosses exhibit differences in addiction risk traits and cocaine behavioral sensitivity
8MaliaBautistamaliarb@uci.eduThe Missing Lynx: The Role of Lynx2 in Nicotine Relapse
9Andrew W.Bergenawbergen2@gmail.comStable Methadone Dose, Toxicology & Treatment Retention in New Jersey MAT
10AritraBhattacherjeeAritra.Bhattacherjee@childrens.harvard.eduA molecularly and spatially defined prefrontal cortical circuit regulating drug relapse
11JenniferBlackburnJennifer.blackburn@yale.eduMultiplex Cytokine Profiling and Single Nuclei RNAseq Reveal Anti-Inflammatory Changes Following Intravenous Δ-9 Tetrahydrocannabinol Administration Among Healthy Participants
12KennethBlumdrd2gene@Gmail.comPreaddiction Phenotype is Associated with Dopaminergic Dysfunction: Pharmacogenomic Evidence from 88.8M GWAS-Based Samples
13KaseyBridakbrida@uab.eduReelin regulates striatal excitability & cocaine reward
14Russell W.Brownbrown1@etsu.eduUnderlying Mechanisms of the Effects of Nicotine in a Heritable Model of Drug Abuse Vulnerability in Psychosis
15JasonBubierJason.bubier@jax.orgHost genetics, microbiome composition and addiction/addiction-related behavior in mice
16CaliCalarcoccalarco@som.umaryland.eduRegulation of gene expression in striatal input regions by cocaine self-administration
17RianneCampbellrcampbell@som.umaryland.eduCocaine-induced Changes in Gene Expression and Regulation within GABAergic Ventral Pallidum Cell Types
18NazzarenoCannellanazzareno.cannella@unicam.itLong-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in NIH Heterogeneous Stock rats.
19LieselotCarrettelcarrette@health.ucsd.eduCharacterization of the whole-brain reactivity and functional connectome associated with analgesia through MOR and KOR agonism.
20Luis FSCastro-de-Araujoluis.araujo@vcuhealth.orgDynamic Growth of ADHD Symptoms in Youth: Estimating Variance Components of Latent Growth Factors and their Associations with Genetic Liabilities to Substance Use and Abuse
21Samar NasserChehimisamar.chehimi@pennmedicine.upenn.eduFentanyl-xylazine interaction induces transcriptional modifications in the nucleus accumbens of Sprague Dawley rats
22HaoChenhchen@uthsc.edu1.) Sex and heredity are determinants of oral oxycodone self-administration in 36 Inbred Rat Strains: correlations with behavioral tests of anxiety and novelty-seeking
23LaurensHolmes, Jr.lholmes@desu.edu1.) DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) Implication in Substance Use Disorders (SUD) in Essential Hypertension
24YoushuChengyoushu.cheng@yale.eduA hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data
25MeghanChenowethmeghan.chenoweth@utoronto.caSex-Dependent Genetic Architecture of Tobacco-Related Biomarkers
26RichardCristcrist@pennmedicine.upenn.eduSingle nucleus ATAC-seq of the central amygdala reveals patterns of chromatin accessibility associated with the cocaine self-administration rats
27M. ImadDamajm.damaj@vcuhealth.orgGenetic Variation in nicotine withdrawal in mice using reduced complexity cross
28Giordanode Guglielmogdeguglielmo@health.ucsd.eduExploring Genetic Influences on Alcohol Use Disorder: A Comprehensive Study of Addiction-like Behaviors in Heterogeneous Stock Rats
29DanielleDickdanielle.m.dick@rutgers.eduCharacterizing Addiction Risk Across Development in Large Epidemiological and Population-Based Samples
30Scott R.Diehlscott.diehl@rutgers.eduStrain Differences in Susceptibility to Opioid Side Effects In Female Mice
31EamonnDuffyEamonn.duffy@colorado.eduSex and genetic background influence intravenous oxycodone self-administration in the Hybrid Rat Diversity Panel
32FangFangffang@rti.orgExposure- and genetically driven epigenetic associations with lifetime cannabis use.
33ZoeFigueroazfigu001@ucr.eduInflammation driven astrocyte responses during neuroinflammation caused by chronic methamphetamine exposure
34Heidi S.Fisherheidi.fisher@jax.orgIdentification of strain differences in transcriptional responses to cocaine across stages of drug self-administration in mice with high and low rates of acquisition and extinction
35Bryan C.Quachbquach@rti.orgTranscriptomic analyses identify genes mediating frequent cocaine use effects on HIV latent reservoir quantity
May 23 – Poster Session B (4:00–5:30 p.m.)
Poster NumberFirst NameLast NameEmailAbstract Title
1Xiao-BingGaoxiao-bing.gao@yale.eduTranscriptomic study reveals changes in gene expressions in the lateral hypothalamic area in socially isolated mice: relevance to drug addiction
2IvyGarrentonigarr001@odu.eduDissecting the Etiology of Alcohol Use Disorder by an Integrative Heritable Component Approach
3Henri M.Garrison-Desanyhgarrisondesany@hsph.harvard.eduAssociation of cord blood DNA methylation patterns and scores with prenatal exposure to opioids, cannabis, and polysubstances
4EmmaGnatowskignatowskie@vcu.eduMechanisms of Ethanol Anxiolysis: Role of Global Ninein Deletion On Ethanol and Anxiety-Like Behaviors. a Cas1sf derived system for CRISPR epigenome editing of fentanyl regulated hub genes.
6NickGreengreenni@iu.eduCell Type-specific Changes in the Caudate Nucleus of Human Postmortem Brains Induced by Alcohol Use Disorder
7Benjamin H.GrissomBgrissom@som.umaryland.eduA single-cell multi-omic atlas of the ventral pallidum reveals VGLUT1 neuron-specific transcriptional responses in immediate and prolonged forced abstinence from heroin self-administration
8HongshengGuihgui1@hfhs.orgIntegrative Omics for studying opioid use disorder and suicidality in African Americans
9PeterHamiltonPeter.Hamilton@vcuhealth.orgThe function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations
10Elaine K.Hebda-Bauerhebda@med.umich.eduThe Hippocampus and Nucleus Accumbens Show Unique and Shared Gene Expression Patterns in a Selectively Bred Rat Model of Contrasting Temperaments that Impact Drug Use
11HaoChenhchen@uthsc.edu2.) Genetic Association of Socially Acquired Nicotine Self-administration in Adolescent Outbred Rats Identifies Candidate Genes Shared with Human Smoking GWAS
12LaurensHolmes, Jr.lholmes@desu.edu2.) Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Substance Use Disorder (SUD) Implicated in Early Life Stress and Major Depressive Disorder (MDD) Correlation
13LeanneHoltleanne.holt@mssm.eduAstrocytic CREB regulates the transcriptional and behavioral responses to cocaine.
14ChristianHopferChristian.Hopfer@cuanschutz.eduUsing RNA expression from immune-related cell types in blood to better understand potential influences of THC and CBD on human health
15ChukwudikeIgwechigwe@iu.eduIs Gm22068 a novel epitranscriptomic marker for thirdhand vaping exposure?
16Daniel A.Jacobsonjacobsonda@ornl.govIntegrating Multi-Omics Data through Multiplex Networks: A Novel Team Science-based Framework for Understanding the Mechanisms Underpinning Substance Use Disorders and Comorbid Neuropsychological Conditions
17ChanghoonJeecjee1@uthsc.eduPositive reinforcement produced by stimulation of dopaminergic neurons in C. elegans.
18J. DavidJentschjjentsch@binghamton.eduHeritable differences in incentive motivation are genetically correlated with the excitability of dopamine release in the nucleus accumbens core of inbred mice
19EmmaJohnsonemma.c.johnson@wustl.edu2.) Multi-ancestral genome-wide association study of nicotine dependence reveals strong genetic correlations with other substance use and psychiatric disorders
20MarcusKaulmarcus.kaul@medsch.ucr.eduChronic, low dose methamphetamine and HIV-1 Tat protein lead to neuronal injury, astrocyte activation and gene expression patterns displaying sexual dimorphism
21GregKeelegkeele@rti.orgNetwork biology algorithms identify biological pathways underlying cigarette smoking behaviors
22PanjunKimpkim11@uthsc.eduEnhancer-Promoter interactions in rat prefrontal cortex identified by Hi-C sequencing facilitate functional interpretation of genetic association studies on substance abuse traits
23BrittanyKuhnkuhnb@musc.eduGenome wide association study reveals multiple loci associated with heroin motivation and taking behavior in heterogeneous stock rats
24LeiLiLi129@iit.eduCross-modal Sensory Integration: A New Strategy for SUD Treatment Targeting of HIV Transcription: Impact of Cocaine and Morphine on Latency Reactivation
26Shirelle X.Liuliu00459@umn.eduCommon and unique patterns of gene expression and chromatin accessibility in the rat medial prefrontal cortex across different phases of opioid use disorder
27Falk W.Lohofffalk.lohoff@nih.govMulti-omics analyses of cortical proteome and single cell-type transcriptome identifies novel drug targets for problematic drinking behavior and alcohol use disorder
28AndrewLombardianlo5057@colorado.eduRole of GSCAN-Identified Genes in the Astrocytic Response to Nicotine
29ChangLuchanglu@vt.eduLow-input profiling of epigenomic dynamics in mouse brain to understand prolonged synaptic plasticity
30WilliamLynchwlynch@bu.eduValidating Zhx2 as a candidate gene underlying Oxycodone Metabolite (Oxymorphone) Brain Concentration and Behavior via Gene Editing and -Omics analyses in BALB/cByJ mice
31MakotoTaniguchiTaniguch@musc.eduA long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation
32Min-AeSongSong.991@osu.eduA Potential Contribution of Acrylonitrile to Accelerated Epigenetic Aging of the Lungs of Smokers
33VivekSwarupvswarup@uci.eduUnraveling Transcriptomic Dynamics: Interplay of Opioid Use Disorder and Early Life Adversity in Distinct Brain Regions
34Vivek M.Philipvivek.philip@jax.orgSystems genetics and genomics data resources from the Center for Systems Neurogenetics of Addiction
May 24 – Poster Session C (10:20–11:45 a.m.)
Poster NumberFirst NameLast NameEmailAbstract Title
1BrionMaherbrion@jhu.eduBrain Differential Methylation and Gene Expression following Opioid Overdose
2LisaMaturinlmaturin@health.ucsd.eduThe Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
3MariaMavrikakimmavrika@bidmc.harvard.eduEffects of oxycodone self-administration on gene and microRNA expression
4NicolaMicalinicola.micali@yale.eduDefining the effects of prenatal cannabinoid exposure on primate fetal brain development
5SophiaMiraclesmiracle@bu.eduEffects of Zhx2 liver and brain overexpression on oxymorphone metabolite levels and state-dependent oxycodone reward learning in BALB/cJ mice with a Zhx2 loss-of-function variant
6AmyMoorealmoore@rti.orgLeveraging the All of Us Research Program to Better Understand the Genetic Architecture of Opioid Use Disorder Spectrum Behaviors
7AnnaMoszczynskaei2744@wayne.eduUbiquitin-Protein Ligase Parkin in Methamphetamine Use Disorder
8KaterynaMurlanovakmurlano@buffalo.eduOprm1 deficiency in nucleus accumbens astrocytes increases sensitivity to heroin and reward consumption
9NathanNakatsuka08nanaka@gmail.comA Meta-Analysis Method for Finding Reproducible Differentially Expressed Genes in Single-Cell Transcriptomic Case-Control Studies
10JesseNiehausjesse_niehaus@med.unc.eduAccurately quantifying Oprm1 requires an updated gene annotation. Novel approach for the investigation of X-chromosome inactivation in mice exposed to addictive substances
12EmmanuelOnaiviOnaivie@wpunj.eduCannabinoid type 2 receptor neuro-immune crosstalk following microglia and dopaminergic neuron specific deletion of CB2Rs.
13EmilyOrreorr@wustl.eduApplying high throughput deep mutational scanning to study transcription factors implicated in the biology of Substance Use Disorders
14Abraham A.Palmeraap@ucsd.eduPrescription Opioids Genetic Study (POGS) an innovative instrument for studying the genetic basis traits relevant to opioid use disorder.
15YezhiPanypan@som.umaryland.eduNicotine Addiction Functional Networks: A Whole-Brain Connectome Analysis in 24,000 Individuals
16Ying-XianPanyx.pan@rutgers.edu1.) Exploring molecular mechanisms underlying fentanyl overdose-induced toxicities via Oprm1 exon 1-associated variants using tandem mass tag-based phosphoproteomics/proteomics
17QianPengqpeng@scripps.eduGenetic Interactions in Alcohol Use Disorder in a High-Risk Population
18Roseann E.Petersonroseann.peterson@downstate.eduExpanded Empirical Population Assignments in Biobanks Empower Ancestrally Inclusive Genetic Studies of Substance Use Disorders
19ChaitanyaSrinivasancsriniv1@andrew.cmu.eduSignatures of DNA Damage and Epigenetic Erosion in Opioid Use Disorder
20No Poster
21MartaPratellimpratelli@ucsd.edu1.) Dopamine-induced change in transmitter phenotype is a shared mechanism for drug-induced generation of cognitive deficits
22ElizabethYenelizabeth.yen2@tuftsmedicine.org1.) Insulin Sensitivity and Body Composition Effects of Prenatal Opioid Exposure
23Andrea D.Raymondadraymon@fiu.eduModulation of microRNA profiles in extracellular vesicles by HIV infection and opiates
24WalkerRogersrogersw@vcu.eduInvestigating Transcriptomic Responses to Ethanol Analgesia Over Time in C57Bl/6J And DBA/2J Mouse Lines
25CherylRosenfeldRosenfeldC@missouri.eduA Novel Single Nuclei Sequencing Approach to Examine Effects of Oxycodone on Parietal Trophoblast Giant Cells in the Mouse Placenta Enhancer Loci (VEL) due to Opioid Overdose Impact Forebrain Neuronal Function
27LauraSabaLaura.Saba@cuanschutz.eduCell-type specific genetic effects and changes due to oxycodone exposure in RNA expression levels and co-expression networks in rat prefrontal cortex
28SandraSanchez-Roigesanchezroige@ucsd.eduCharacterizing cases and controls for opioid use disorders using electronic health records: a phenomic and genomic exploration in over 1 million individuals
29Pietro PaoloSannapsanna@scripps.eduDrug self-administration in a rodent model of HIV: from RNA-Seq to druggable targets.
30KirtiSharmasharmki@iu.eduOne person's nicotine addiction may affect another person's liver
31Jakob (Koby)Shaykink.shaykin@uky.eduGenomic Assessment of the Prefrontal Cortex in Differential Responsivity of Sucrose Preference and Fentanyl Escalation in Sprague-Dawley Rats The NIDA, ABCD, HBCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans
33JeremyShermanjeremy.sherman@icahn.mssm.eduMultimodal RNA-sequencing of the dorsal striatum identifies a link between H3K27 dysregulation and neurodegenerative phenotypes in heroin use.
34StephanieSillivanstephanie.sillivan@temple.eduIntegrated analysis of sex-specific regulation of RNA networks in the rat orbitofrontal cortex following heroin self-administration A zinc finger transcription factor in the nucleus accumbens regulates cocaine-induced transcription and behaviors in a cell type specific manner
36N. DaltonFitzgeraldndf@uab.eduNeuronal activation by cocaine varies across molecularly-defined subpopulations of VTA dopamine neurons
May 24 – Poster Session D (2:30–4:00 p.m.)
Poster NumberFirst NameLast NameEmailAbstract Title
1MadhurbainSinghsinghm18@vcu.eduPutative Proximal and Distal Effects between Smoking and Alcohol Consumption: Causal Inference from Models Integrating Polygenic Scores with Longitudinal Data
2OmarSoler-Cedenoomar.soler-cedeno@nih.govDissecting the functional roles of GABAergic vs. glutamatergic neurons in opioid reward using conditional mu opioid receptor-knockout mice
3Jung SooSukjsuk@som.umaryland.eduCombination of focused ultrasound and long-circulating nanoparticles for nucleic acid delivery to the brain
4KyleSullivansullivanka@ornl.govMulti-omic integration uncovers biological pathways underlying HIV viral load
5JingSunjsun54@jhmi.eduReduced level of circulating cell-free nuclear and mitochondrial DNA fragments among Persons who Inject Drugs with HIV
6LisaTarantinolisat@med.unc.eduRepeated exposure to cocaine produces strain specific differences in incentive sensitization in Collaborative Cross mice
7ZacharyTatomtatomz@vcu.eduCar8 knockout in prefrontal cortex increases voluntary ethanol consumption in male mice
8FrancescaTeleseftelese@ucsd.eduTSS-MPRA to decode regulatory functions of genetic variants associated with substance use disorders.
9StellaTommasitommasi@med.usc.eduEpigenomic dysregulation in youth vapers: implications for disease risk assessment
10GuyTwagtwa@uab.eduAccurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns
11MuditTyagiMudit.Tyagi@jefferson.eduCocaine enhances HIV infection, gene expression and replication by stimulating cell metabolism
12Alp MeteUmnetaummet@clemson.eduVariation in Mushroom Body Morphology in Cocaine Preferring Drosophila Genetic Reference Panel Lines
13Mary-ElizabethZipparomzippar1@jhmi.eduPast cocaine exposure durably alters CD4+ T-cell reservoir seeding and reactivation SIV-infected ART-suppressed macaques
14AvinashVeerappaaveerappa@unmc.eduOMICS Perspectives Unveil Neural Circuitry Adaptations in Chronic Heroin Addiction: A Genome-Wide Analysis of Epigenetic Signatures and Transcriptional Programs of blood metabolite biomarkers for oxycodone exposure in rats through metabolomics
16HaohanWanghaohanw@illinois.eduUnderstanding Variations in Regulatory Networks Across Cell Types through Transformer Model with Knowledge on Regulatory Interactions
17Bradley T.Webbbwebb@rti.orgDeep ascertainment and genetic architecture of alcohol use disorder and related outcomes in All of Us.
18JulieWhitejdwhite@rti.orgComparison of DNA methylation signals across substances reveals shared biological implications for substance use
19CarynWilliscdwillis@rti.orgMeta-analyses of gene expression differences associated with alcohol use disorder in human brain
20KellyWingfieldkelwing@bu.eduExploring mouse ultrasonic vocalizations as a tool to study negative affective states in mice using a mouse model of neonatal opioid withdrawal syndrome (NOWS)
21Zheng-XiongXizxi@intra.nida.nih.govNeuronal versus glial CB2 receptor: Findings from a new strain of CB2-KO-EGFP reporter mice
22KeXuKe.Xu@yale.eduEpigenome-wide characterization reveals aberrant DNA methylation of host genes regulating CD4+ T cell HIV-1 latent reservoir size in women living with HIV
23RongguangXuroxu@bwh.harvard.eduInvestigating the Impact of Histone Post-Translational Modifications on Nucleosome Structure and Accessibility: Insights from Molecular Dynamics Studies
24Ege A.Yalcinbasege.yalcinbas@libd.orgTranscriptomic changes in habenula following chronic fentanyl self-administration in rats
25FengchunYefxy63@case.eduNurr-est neighbors: RXR induces epigenetic silencing of HIV-1 in microglial cells
26ZhenyaoYezye@som.umaryland.eduAlcohol-Induced Alterations in Brain Functional Connectivity: Insights from Whole-Brain Data-Driven Analysis in Older Adults
27MartaPratellimpratelli@ucsd.edu2.) Pipeline for whole-brain analysis of METH-induced changes in neurotransmitter phenotype
28ElizabethYenelizabeth.yen2@tuftsmedicine.org2.) Molecular Evidence of Sex-Specific Effects in Neonates with Prenatal Opioid Exposure
29XinxuYuanXinxu.yuan@vcuhealth.orgAll-in-one AAV delivery of multiplexed hypercompact OsCas12f/sgRNAs to eradicate HIV
30ZhuzhuZhangzhuzhuzhang@uchicago.eduSingle-Cell Resolution and Circuit-Level Dissection of Epigenomic Remodeling in Addiction
31JianZhujian.zhu@osumc.eduContribution of Methamphetamine-Induced Dysregulation of RNA Methylation to Promoting HIV Infection in Microglia/Macrophages
32LeaZillichlea.zillich@zi-mannheim.deCell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus suggests phosphodiesterases as a pharmacological target
33RajtarunMadangopalrajtarun.madangopal@nih.govIn vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
34KatherineSavellKatherine.savell@nih.govCell-type-specific transcriptional signatures of cocaine relapse in the rat medial prefrontal cortex