NIDA Genetic Consortium Meetings & Abstracts

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the September 11-12, 2025 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations. Registration is now closed.

There is no registration fee to attend this meeting. However, attendees are responsible for their own travel, meals, and lodging. The goals of the meeting are to:

  • Showcase the exciting research on the genetics and epigenetics of substance use disorders
  • Encourage collaboration amongst investigators with different expertise in genetics and epigenetics
  • Foster collaboration and new research among investigators working on the genetics and epigenetics of addiction and HIV/AIDS, mental health, and other comorbidities
  • Identify new research opportunities in the genetics and epigenetics of addiction
  • Provide attendees with an opportunity to meet with NIDA program directors to discuss their ideas for grant applications and funding opportunities

Registration and Meeting support information

When accessing the abstracts please note, the abstract preview may not appear correctly if you are using the Adobe Acrobat plugin in the Chrome browser. Please either turn off the Adobe Acrobat plugin or use another browser (Edge, Firefox, etc.) to view the abstracts.

Impact of Substance Abuse on HIV Gene Expression and Neuroinflammation Dynamics

Thursday, September 11, 2025
TimeSessionChairsRoom
9:00WelcomeJonathan Pollock
Udi Ghitza
Amy Lossie		Auditorium
9:05Session 1: Using Large-Scale Genetics to Decipher Signaling Networks that Regulate Opioid Behavioral ResponsesBrock GrillAuditorium
9:30Opening RemarksNora VolkowAuditorium
9:40Session 2: CoGenome-Scale Exploration of the Opioid-Exposed Human Brain – From Tissues to Cells to Single Chromatin FibersOlivia Corradin
Eric Johnson		Auditorium
10:45Poster Session A Atrium and Balconies
12:15Lunch
1:30Session 3: Concurrent Panels
Harnessing Model Organism Genetics and Genomics in the Understanding the Role of Human Genetic Variation in SUDs

Or		Elissa Chesler
Abraham Palmer		 
Impact of Substance Abuse on HIV Gene Expression and Neuroinflammation DynamicsMudit Tyagi
Palsamy Periyasamy		 
3:00Session 4: Short Talks Auditorium
4:00Poster Session B Atrium and Balconies
5:30Adjourn  
Friday, September 12, 2025
TimeSessionChairsRoom
9:00WelcomeJonathan Pollock
Udi Ghitza
Amy Lossie		Auditorium
9:05Session 5: Molecular and Cellular Logic Underlying Drug-Seeking and Relapse Across Cell Type- and Circuit-Specific PopulationsIan Maze
Keri Martinowich		Auditorium
10:30Poster Session C Atrium and Balconies
12:00Lunch
1:15Session 6: Concurrent Panels
Regulation of Alternative Splicing in Addiction

Or		Elizabeth A Heller
Amy Lasek		 
Clinical Utility of Implementation of Genetic Data into Personalized Medicine Approach to Substance Use Disorder (SUD)Tanya Ramey
Albert Arias		 
2:30Poster Session D Atrium and Balconies
4:00Session 7: Short Talks Auditorium
5:30Adjourn  
September 11, 2025 – Session 1: Using Large-Scale Genetics to Decipher Signaling Networks that Regulate Opioid Behavioral
Responses (9:00 AM – 9:40 AM)
NameEmailAbstract Title
Jonathan Pollock
Udi Ghitza
Amy Lossie		 Welcome
Brock Grillbrock.grill@seattlechildrens.org Session 1: Using Large-Scale Genetics to Decipher Signaling Networks that Regulate Opioid Behavioral Responses
Nora Volkow Welcome from NIDA Director
September 11 - Session 2: CoGenome-scale Exploration of the Opioid-Exposed Human Brain - From Tissues to Cells to Single Chromatin Fibers (9:40–10:45 a.m.)
Co-Chairs:
Olivia Corradin, Ph.D., Massachusetts Institute of Technology
Eric Johnson, Ph.D., RTI International
NameEmailAbstract Title
Olivia Corradincorradin@wi.mit.edu Epigenetic variation linked to opioid overdose converge on splicing regulators in the nucleus accumbens
Aileen Harnettaileen.harnett@mssm.edu Genome-scale long-read single molecule sequencing for nucleosome position mapping and transcription factor footprinting in opioid exposed and control prefrontal cortex
Caryn Williscdwillis@rti.org Differential gene expression of opioid overdose death across human brain regions
September 11 – Session 3: Concurrent Panels (1:30–3:00 p.m.):
Harnessing Model Organism Genetics and Genomics in the Understanding the Role of Human Genetic Variation in SUDs
Co-Chairs:
Elissa Chesler, Ph.D., The Jackson Laboratory
Abraham Palmer, Ph.D., University of California San Diego
NameEmailAbstract Title
Elissa Cheslerelissa.chesler@jax.org Using Mouse Behavioral Phenomics to Interpret and Model Genetic Variation in Substance Use Disorders
Abraham Palmeraap@ucsd.edu Genetic evidence supports a relationship between locomotor activity in a novel environment in rodents a human externalizing behavior
Marianne Seneyseneyml@upmc.edu Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in  Human and Rodent Brains
Xia Yangxyang123@g.ucla.edu Mergeomics, A Multiomics Integration and Network Modeling Tool and Its Applications in Addiction Research
Impact of Substance Abuse on HIV Gene Expression and Neuroinflammation Dynamics
Co-Chairs:
Mudit Tyagi, Ph.D., Thomas Jefferson University
Palsamy Periyasamy, Ph.D., University of Nebraska Medical Center
NameEmailAbstract Title
Shilpa Buchsbuch@unmc.edu  Extracellular vesicles and microRNA crosstalk: Modulators of neuroinflammation in HIV-1 and opioid-associated neurocognitive disorders
Palsamy Periyasamypalsamy.periyasamy@unmc.edu Epigenetic Regulation of NLRP6 Inflammasome in Methamphetamine-Induced Neuroinflammation and Astrocyte Pyroptosis
Mudit Tyagimudit.tyagi@jefferson.edu Cocaine enhances HIV infection, gene expression, and replication by stimulating  cell metabolism through the regulation of multiple pathways
September 11 – Session 4: Short Talks (3:00–4:00 p.m.)
NameEmailAbstract Title
Risa Watanaberisa.watanabe@mssm.edu Chromatin Fiber Profiling and Transcription Factor Footprinting by Genome-Scale Single Molecule Sequencing from Opioid Use Disorder and Control Brain
Nana Amissahnanaamis@buffalo.edu Genomic Loci Influencing Addiction-Like Behaviors During Cocaine Self-Administration
Julie Blendyblendy@pennmedicine.upenn.edu Spatial Transcriptomics Reveals Distinct Cell Type Dynamics Following the Development of Opioid Dependence
Zhong Chenzchen@llu.edu  Paired-Tag Single-Cell Joint Profiling of H3k27me3-H3k4me1 and Transcriptome Revealed Prenatal E-Cigarette Induced Abnormal Neuronal Lineage Development in Rat Neonatal Prefrontal Cortex
Andrew Ricearice@bcm.edu Single-cell Analysis of Prefrontal Cortex Reveals Cell Specific Accelerated Aging in People with HIV-1
Deziree Colemandezcole@uw.edu Cross-Species C. Elegans Model of Opioid-Induced Behavior Identifies Gao and a Multi-Layered RGS Profile Mediating Opioid Receptor Signaling
Xiaoke Duanxiaoke.duan@yale.edu Single Nucleus Transcriptome and Chromatin Analysis Identifies Basal Ganglia Differentially Expressed Genes for SIV Infection in Rhesus Macaques: Preliminary Findings
Elaine Hebda-Bauerhebda@umich.edu Triangulating Genotyping, RNAseq, and Spatial Transcriptomics in a Rat Model of Temperament and Addiction
Daniel Jacobsonjacobsonda@ornl.gov   Human-First Drug Repurposing for Addiction: From AI-Informed Multi-Omics Systems Biology Through Candidate Drug Validation and Trial Emulation
September 12 – Session 5: Molecular and Cellular Logic Underlying Drug-Seeking and Relapse Across Cell Type- and Circuit-Specific Populations (9:05–10:30 a.m.)
Co-Chairs:
Ian Maze, Icahn School of Medicine at Mount Sinai
Keri Martinowich, Johns Hopkins University
NameEmailAbstract Title
Newaz AhmedNewaz.ahmed@mssm.edu   Ex-specific chromatin and transcriptional signatures in medial prefrontal cortex following heroin exposures
Soren Emersonsoren.d.emerson@vanderbilt.edu Molecular Determinants of Ensemble Recruitment
Isaiah Williamsoniwilliamson@som.umaryland.edu Adaptations in the parabrachial nucleus after chronic opioid exposure and withdrawal
Beau Osterbeauo@jhmi.edu Transcriptional impact of chronic fentanyl self-administration on habenula circuits
September 12 – Session 6: Concurrent Panels (1:15–2:30 p.m.): Regulation of Alternative Splicing in Addiction
Co-Chairs:
Elizabeth A Heller, Ph.D., University of Pennsylvania
Amy Lasek, Ph.D., Virginia Commonwealth University
NameEmailAbstract Title
Luana CarvalhoLuana.MartinsdeCarvalho@vcuhealth.org  PCBP1-Mediated Alternative Splicing in the Hippocampus During Alcohol Withdrawal
Elizabeth Hellereheller@pennmedicine.upenn.edu Chromatin- and activity-mediated alternative splicing in sucrose and cocaine reward
Karla Kaunkarla_kaun@brown.edu Functional consequences of alternative splicing in polysubstance use
Rohan PalmerRohan.Palmer@Emory.edu Genomic and Transcriptomic Splicing Associations in Opioid and Alcohol Use Disorder
Clinical Utility of Implementation of Genetic Data into Personalized Medicine Approach to Substance Use Disorder (SUD)
Co-Chairs:
Tanya Ramey, M.D., Ph.D., NIDA
Albert Arias, M.D., Virginia Commonwealth University
NameEmailAbstract Title
Albert Ariasalbert.arias@vcuhealth.org  Toward Precision Treatment of Substance Use Disorders with Machine Learning Models and Pharmacogenetics
Laura Jean BierutLaura@wustl.edu Polygenic scores for substance use disorder:  Uses for prevention and treatment
Danielle DickDanielle.m.dick@rutgers.edu Integrating Genomic and Environmental Information to Deliver Personalized Feedback on Substance Use Disorder Risk: The Comprehensive Addiction Risk Evaluation System (CARES)
September 12 – Session 7: Short Talks (4:00–5:00 p.m.)
NameEmailAbstract Title
Matthew Lanelanemj@ornl.gov Binding Pathways to Break Addiction: Multiomic Insights into GLP-1R Agonist Therapeutics for Cigarette Smoking and Opioid Addiction
Joseph Nadeaujnadeau3@mmc.orgNon-Genetic Non-Environmental Phenotypic Variation in Health and Disease
Emilly Orreorr@wustl.edu  Applying High Throughput Deep Mutational Scanning (DMS) to Study Transcription Factors (Tfs) Implicated in the Biology of Substance Use Disorders (SUD)
Andreas Pfenningapfenning@cmu.edu  Cell Type Specific Enhancers for the Primate Dorsolateral Prefrontal Cortex
Ana Pomboapombo1@ju.edu A Single Exposure to Cocaine Rewires the 3D Genome Structure of Midbrain Dopamine Neurons
Holly Pooreholly.poore@rutgers.edu Advancing Gene Discovery for Substance Use Disorders Using Additional Traits Related to Behavioral Disinibition
Melody Rivera-Hernándezmelody.rivera-hernandez@yale.edu Prioritizing Brain Cell Types and Biological Processes Linked to OUD-Associated Common Genetic Variants
Katherine Savellkatherine.savell@nih.gov Identifying the Transcriptional Fingerprint of a Drug Reward Memory
Jing Sunjsun54@jhmi.edu Reduced Mitochondrial DNA Copy Number in Persons who Inject Cocaine and Heroin
September 11 – Poster Session A (10:45 a.m.–12:15 p.m.)
Poster NumberNameEmailAbstract Title
2Luis Araujoluis.araujo@vcuhealth.org Longitudinal bidirectional effects between ADHD and educational performance in the ABCD study
3Svitlana Bachsvitlana.bach@libd.org Molecular profiling of the human nucleus accumbens with spatial and single nucleus resolution
4Ryan Bachtellbachtell@Colorado.edu Dysregulated oxycodone use in select inbred rat strains from the Hybrid Rat Diversity Panel
5Roberto Baileyrobertobailey@hunterschools.org Prenatal Cannabis Exposure and Neurodevelopmental Gene Up-regulation: Longitudinal Impact on Childhood Cortisol Levels
7Brad Baldersonbbalderson@salk.edu Decoding the Biological Basis of Opioid Addiction using Single Nuclei RNA-seq and Chromatin Accessibility from the Nucleus Accumbens of Outbred Rats
9Britahny Baskinb.baskin@northeastern.edu Cocaine intravenous self-administration in near-isogenic Spontaneously Hypertensive Rat substrains bred in-house and QTL analysis of cocaine locomotor sensitivity and gene expression (RNA, protein) in an F2 cross
10Andrew Bergenawbergen2@gmail.com Demographic and Social Determinants of Methadone Dose and Treatment Outcomes Among Patients Receiving Medication Assisted Treatment in New Jersey Based Programs
12Jennifer Blackburnjennifer.blackburn@yale.edu Physiological and immunomodulatory effects of Δ-9-tetrahydrocannabinol depend on HIV serostatus
13Claire Brabanderclaire.brabander@qc.cuny.edu Susceptibility to substance use initiation: the developmental cascade from placental HPA-axis programming to infant temperament
14Elissa CheslerElissa.Chesler@jax.org Host genotype affects microbiome composition and behavior
15Cali Calarcoccalarco@som.umaryland.edu Regulation of metabolism-related gene expression by cocaine self-administration in mouse nucleus accumbens circuits
16Samar Chehimisamar.chehimi@pennmedicine.upenn.edu Multiomic analysis uncovers gene expression and chromatin accessibility changes in the nucleus accumbens of rats after cocaine self-administration
17Hao Chenhchen@uthsc.edu Initial QTL mapping of oral oxycodone self-administration in the hybrid rat diversity panel
18Ke Xuke.xu@yale.edu Inferred cell-type-specific methylation quantitative trait loci for cannabis use
19Raymond Chienrc1268@njms.rutgers.edu Investigating the molecular mechanisms underlying morphine tolerance using tandem mass tag-based phosphoproteomics/proteomics
20Maia Choimaia.choi@rutgers.edu Genetic, neural, psychological, and environmental factors are uniquely associated with onset of alcohol use in the Adolescent Brain Cognitive Development (ABCD) study
22Konrad Dabrowskikonrad.dabrowski@mssm.edu Chromatin accessibility patterns in peripheral blood cells as predictors of opioid dependence and recovery
23Genevieve Dashgenevieve.dash@rutgers.edu Implementation of a Genetically-Informed Personalized Feedback Intervention
24Christal Davischristal.davis@va.gov Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans
26Joseph DeakJoseph.Deak@yale.edu A large-scale genome-wide association meta-analysis study of cocaine use disorder
27Michelle Doylem3doyle@health.ucsd.edu From Genes to Treatments: Leveraging Rat Genetic Diversity to Unlock Novel Therapeutic Targets in Alcohol Use Disorder
28Eamonn Duffyeamonn.duffy@colorado.edu Oxycodone self-administration alters the diversity and composition of the fecal and cecal microbiome in two genetically divergent rat strains
30Michael Emeryemeryma@med.umich.edu Comparison of intravenous self-administration of psychostimulants vs. opioids in an animal model of internalizing vs externalizing temperament
31Fang Fangffang@rti.org Reversibility of DNA Methylation Changes Associated with Cannabis Use
32Madeline Fishmadeline.fish@umassmed.eduUsing single cell multiomics to discover novel factors in the brain involved in co-occuring opioid addiction and major depression
34Leigh Flynnltf28@drexel.edu Effects of Intraperitoneal Psilocybin on DNA Methylation and Electrophysiological Markers of Plasticity
35Chen FuChen.Fu@umassmed.edu Increased somatic mutation rate and transcriptome noise in OUD patients in NAc and sgAcc
36Michael Garvinmike@williwawbio.com Long-read sequencing identifies CYP2D6 haplotype associated with frequent cocaine use
37Olivier Georgeolgeorge@health.ucsd.edu The Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration
38Laura Goetzllaura.goetzl@uth.tmc.edu Prenatal cannabis exposure alters miRNA expression in the developing human brain
39Gbadebo Ogungbadedebogungbade@gmail.com RN3C1 Glucocorticoid Receptor Gene and Serotonin Gene (5-HTT) Aberrant Epigenomic Modulation in Maternal Depressive Disorders (MDD) among Racial/Ethnic Minorities in the US: Quantitative Evidence synthesis (QES)
40Stephanie JonesStephanie_K_Jones@baylor.edu Early cannabis use in adolescents associates with high-order gene by environment interactions identified by machine learning
September 11 – Poster Session B (4:00–5:30 p.m.)
Poster NumberNameEmailAbstract Title
2Struan Grantgrants@chop.edu Shared and unique 3D genomic features of substance use disorders across multiple cell types
3Feng Guofrankfengguo@gmail.com Engineering human brain organoids for understanding substance use disorders
4Gbadebo Ogungbadedebogungbade@gmail.com Pediatric Chronic Oxycodone and CYP2D6 Aberrant Epigenomic Modulations in Autistic Spectrum Disorders (ASD): Quantitative Evidence Synthesis (QES)
5Michael Garvinmike@williwawbio.com Biologically-driven epistasis as a new way of approaching genetic analyses of addiction
6Jason Hammondsjason.hammonds@cchmc.org HIV infection induces rapid activation of HAND-associated inflammatory signatures in microglia
7Emily Hartwellemily.hartwell@pennmedicine.upenn.edu Stratified multi-ancestry GWAS of alcohol use and depression: Unique genetic architecture
9Jinshan Hejinshan.he@osumc.edu Methamphetamine-Induced Upregulation of Deubiquitinating Enzymes (DUBs) Promote HIV Proviral Transcription by Enhancing SWI/SNF Chromatin Remodeling Complex
10Charles Hoeffercharles.hoeffer@colorado.edu Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
11Ava HolmesAva.Holmes@nih.gov MultipleXed Population Selection and Enrichment single nucleus RNA sequencing (XPoSE-seq) enables sample identity retention during transcriptional profiling of target populations
12Yike Huangy.huang@wi.mit.edu Linking Stress to Opioid Addiction: Exploring Genetic and Neuroepigenetic Mechanisms
13Jessica Huebschmanhuebschm@musc.edu NPAS4-Expressing Ensemble in the Nucleus Accumbens Facilitates Reward-Related Behavior
14I-Tzu Hungih256@rutgers.edu Detecting rGE between Exposome Factors and Polygenic Risk Scores for Psychiatric and Substance Use Disorders in the Adolescent Brain Cognitive Development Study
15Rohan Palmerrohan.palmer@emory.edu Examining the Effects of Prenatal Cannabis Exposure & Genetic Risk for Externalizing Traits on Executive Functioning and Behavioral Disinhibition in Early Adolescence
16Natalia Jaume-Feliciosinjaume@emory.edu The Co-Occurrence of Internalizing Disorders and Alcohol Use Disorder: An Examination of Childhood Trauma and Epigenetic Cellular Aging
17Alvin Jefferya.jeffery@vumc.org Precision Phenotyping of Opioid Use Disorder for Multiple Populations
18Zeal Jinwalazeal@wustl.eduPredicting Treatment-Seeking Status for Alcohol Use Disorder- A machine learning approach
19Ken Johnsonken.b.johnson@hsc.utah.edu mRNA & miRNA expression in taxane induced peripheral neuropathy during taxane treatment: A 12-month longitudinal analysis
20Stephanie JonesStephanie_K_Jones@baylor.edu  Polygenic risk scores incorporating functional genomics improve prediction of smoking cessation
22Marcus Kaulmarcus.kaul@medsch.ucr.edu Methamphetamine increases release of pro-inflammatory cysteinyl leukotrienes and neurotoxicity of HIV-infected iPSC-derived microglia
24Yousef Khanyousef.khan@pennmedicine.upenn.edu Multi-Ancestry Genome-Wide Association Meta-Analysis of Buprenorphine Treatment Response
26Vidhya Kumaresanvidhya@bu.edu Abstinence from Escalated Cocaine Intake Alters the microRNA Landscape in the Medial Prefrontal Cortex
27Phil LeePLEE0@mgh.harvard.edu Environmental, Genetic, and Neural Correlates of Adolescent Polysubstance Use: Insights from the ABCD Study
28Adele Leggieria.leggieri@qmul.ac.uk Genetic and Developmental Analysis of Zebrafish Reveals Candidate Genes Linked to Nicotine Addiction Vulnerability and Impulsivity
29Paige Lemenplemen1@uthsc.edu Adolescent Social Isolation Increases Sensitivity to Pain and Opioid Use in Adulthood in Rats
30Lingyong Lilingyongli@uabmc.edu Tiam1 signaling in morphine-induced behavioral and structural plasticity
31Ming Lilimd586@outlook.com Multiomics analyses reveal significant association of SNP rs148582811 in ARVCF with smoking addiction by affecting nicotine-associated hippocampus-dependent
32Mingrui Limingrui.li@yale.edu Delta-9-Tetrahydrocannabinol Dynamically Alters Transcriptome at Single-Nucleus Resolution in Humans
33Xiaoyu Liangliangx20@msu.edu Tobacco Exposure is Associated with Unique Cell-Type Specific Epigenetic Modifications Across Immune Cell Types
34Hongyu Linhlin123@umd.edu A novel role of submedius thalamus and its projections to orbitofrontal cortex in incubation of oxycodone craving after forced abstinence
35Z. Carl Linzlin@mclean.harvard.edu Human epistatic mechanisms in polysubstance use disorders
36Duan Liuliu.duan@mayo.edu Alcohol Use Disorder Associated Gene FNDC4 Affects Glutamatergic and GABAergic Neurogenesis in Human iPSC-derived Neural Organoids
37Shirelle Liuliu00459@umn.edu Epigenetic regulation in the medial prefrontal cortex underlying vulnerability to opioid use disorder throughout its trajectory in male and female rats
38Shuai Liushuai.liu@som.umaryland.edu Cellular and molecular adaptations from cue-induced cocaine relapse within VTA- projecting ventral pallidum neurons in mice
39Andrew Lombardianlo5057@colorado.edu Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
40Cecilia McCormickcmccormick@nygenome.org A Single Cell Approach to Study Cocaine Use Disorder
September 12 – Poster Session C (10:30 a.m.–12:00 p.m.)
Poster NumberNameEmailAbstract Title
1Chang Luchanglu@vt.edu Neonatal opioid exposure alters epigenomic regulations of immune response genes in mouse brain
2Qing Lulucienq@ufl.edu Mixed Deep Learning for Analyzing Large-scale Substance Use Disorders Genetic Data
3Tianzhou Matma0929@umd.edu Integration of multiple QTL data to reveal the causal relationship between DNA methylation and nicotine addiction
4Hermine Maeshermine.maes@vcuhealth.org Analysis of Transmissible Liability Index in longitudinal twin datasets for studying resistance to substance use
6Travis MallarTMALLARD@mgh.harvard.edu Advancing genomic understanding of externalizing psychopathology via a multi-ancestry GWAS of 3 million individuals
7José-Jaime Martínez-Magañajose.martinez-magana@yale.edu Local ancestry-aware meta-analysis of genome-wide association studies for substance use traits in Latin American populations
8Chloe Mathesoncmatheso@umd.edu Mitochondrial morphology in orbitofrontal cortical neurons during incubation of oxycodone craving
10Alex Milleralexmill@iu.edu  Genome-wide association meta-analysis of early onset cannabis use
11Sophia Miraclesmiracle@bu.edu Enhanced naloxone-precipitated withdrawal-induced aversion following oxycodone administration in Zhx2 knockout mice
13Joseph Mosquerajmosquera@health.ucsd.edu Mapping Brain FOS Reactivity in Genetically Diverse Rats Reveals Cortico-Striatal-Thalamic Network Vulnerabilities Associated with Oxycodone Addiction-like Behavior
14Anna Moszczynskaamosz@wayne.edu Methamphetamine Self-administration Alters Cell Type-specific Gene Expression in the Rat Nucleus Accumbens
15Daniel Munrodmunro@health.ucsd.edu Deep analysis of transcriptome identifies molecular mediators of substance use disorders in rats
16Cassie Nelsonc.nelson@som.umaryland.edu Monitoring Oprm1 expression in the parabrachial nucleus throughout the induction of opioid dependence and withdrawal
17Elliot Nelsonnelsone@wustl.edu The first GWAS of opioid overdose death yields surprisingly strong associations and trans-ancestral agreement
18Wickensonn Norzéwickensonn.norze@temple.edu Differential effects of self-administration of opioid receptor agonists with varying potency on exosomal blood serum and orbital frontal cortex (OFC) miRNA expression patterns
19Carlos Novoacmn5622@psu.edu Genetic background modulates anxiety-related behaviors and the impact of adolescent social stress on acute responses to nicotine in BXD mice
20Jimmy Olusakinjolusakin@som.umaryland.edu  Prenatal Stress and THC Exposure Impact Maternal and Adolescent Behaviors
21Emmanuel OnaiviONAIVIE@WPUNJ.EDU Dopaminergic and microglia Cnr2 gene knockout reveals biased neuroinflammation signaling
22Yingshi Ouyangouyangy@mwri.magee.edu  The impact of prenatal opioid exposure on placental opioid receptors
23Abraham Palmeraap@ucsd.edu Getting the run around: is the locomotor response to a novel environment behavior model a model of human externalizing behavior?
24Rameez Syedrameez.ali.syed@emory.edu CONSILIENCE-GWAS: A Web Resource for Parsed Heritability & Polygenic Score Analysis of Human GWAS Using Heterogeneous Functional Genomics Data
25Qian Pengqpeng@scripps.edu Common Threads: Uncovering Convergent Pathways for Cannabis Use Disorder Across Diverse Populations
26Sonja Plasilsplasil@health.ucsd.edu Gene-wide association study of opioid-induced allodynia during withdrawal in heterogeneous stock rats
29Bryan Quachbquach@rti.org Multi-omic network analysis identifies gene modules linked to both frequent cocaine use and the HIV reservoir in CD4+ T cells
30Fatir Qureshiqureshi@wi.mit.edu  Uncovering Environmentally Associated Epigenetic Regulatory Mechanisms in Opioid Exposure Using Chromatin QTL Mapping and Foundation Models
31Timea Raffaitimea.raffai8@gmail.com Integrated analysis of heroin-induced microRNA and mRNA profiles in the nucleus accumbens reveals concerted regulation of miRNA-mediated pathways
32Barkha Ramnanibarkhar@umich.edu Impact of Opioids on HIV-induced innate immune response and pathogenesis
33Daniel Reeddr55@rice.edu CRISPR epigenome editing for interrogating the role of DNA methylation at Fosb locus
34Benjamin Reinerbcreiner@pennmedicine.upenn.edu Multiomic signatures of early life adversity elucidate mechanisms of adult addiction trajectories
36Mukisa Ronaldmukisaronald17@gmail.com Epigenetic Signatures of Adiposity in Ugandan Populations: An Epigenome-Wide Association Analysis RODAM Study
37Pavana Rottiprotti@wi.mit.edu Understanding the role of insulin signaling in the prefrontal cortex (PFC) of opioid overdose cases
39Laura SabaLaura.Saba@cuanschutz.edu Evidence of genetically-driven latent factors in longitudinal oxycodone self-administration data from the Hybrid Rat Diversity Panel
40Xiaoxi Zhuangxzhuang@bsd.uchicago.edu The RNA-binding protein YTHDF1 mediates translational control by m6A mRNA methylation in learning
41Gbadebo Ogungbadedebogungbade@gmail.com Tryptophan Hydroxylase (TPH) gene and 5-HTTLPR polymorphism in Childhood Suicidal Ideation and Suicide among Children
42Vivek Swarupvswarup@uci.edu Unraveling Transcriptomic Dynamics of Early-Life Adversity and its Sex-Dependent Impact on Opioid Addiction Vulnerability
43Mariella De Biasimarielde@pennmedicine.upenn.eduCHRNA5 is Necessary for the Neuroadaptations Associated with Chronic Alcohol Exposure
September 12 – Poster Session D (2:30–4:00 p.m.)
Poster NumberNameEmailAbstract Title
1Gbadebo Ogungbadedebogungbade@gmail.com Aberrant Epigenomic Modulations of Glucocorticoids Receptor Gene (NR3C1) as Causal Inference in Major Depressive Disorders (MDD): Quantitative Evidence synthesis (QES)
2Gbadebo Ogungbadedebogungbade@gmail.com Glucocorticoid receptor (NR3C1), Serotonin (5-HTT), Glutamate Decarboxylase (GAD1/GAD2)  Genes  in Childhood  Aberrant Epigenomic Modulation in Bipolar Affective Disorder (BPAD) and  Generalized Anxiety Disorders (GAD) in the USA: QES
3Sandra Sanchez-Roigesanchezroige@ucsd.edu Genome-Wide Association Analysis of an in Silico Phenotype Sourced from Clinical notes: The Addiction Behavior Checklist
4Sandra Sanchez-Roigesanchezroige@ucsd.edu Genetic heterogeneity across dimensions of alcohol use behaviors
5Varshini Sathishv1sathis@ucsd.edu  Identifying Genetic Risk Factors for Opioid Use Disorder in Chronic Pain Patients using the AllOfUs Research Dataset
6Samantha Scottsamantha.scott@som.umaryland.edu  Mitochondrial dynamics in ventral hippocampal neurons after prolonged abstinence from cocaine self-administration
7Michael Setzermichael.setzer@usuhs.edu Phenotypic and Genetic relationship between ADHD and SUDs in the Yale-Penn cohort
8Jakob Shaykink.shaykin@uky.edu Evaluating the Role of Microglia in the PFC on Fentanyl Escalation Using PLX 3997 in Sprague-Dawley Rats
9Mike SheldonMichael.Sheldon@sampled.com The NIDA Center for Genetic Studies at SAMPLED Develops Novel Multiomic Solutions for NIDA Investigators: A Case Study
10Eleni Siaesia@clin.au.dk Neuroepigenomics of THC and CBD Exposure during Pregnancy in the Developing Brain
11Maya Solismsolis22@miners.utep.edu Gene X Exposome for Impulsivity
12Sheetal Sreeramsxs2286@case.edu METH induced disruption of homeostasis and HIV mediated neuroinflammation in microglia containing human cerebral organoids
13Kyle Sullivansullivanka@ornl.gov Identifying integrated pathways among multi-omics of nicotine addiction using network embedding approaches
14Boris Tabakoffboris.tabakoff@cuanschutz.edu Revisiting the DNA “Dark Matter”
15Makoto Taniguchitaniguch@musc.edu A long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation
16Lisa Tarantinolisat@med.unc.edu Life at the extremes: leveraging phenotypic diversity to identify mechanisms of substance use disorders
17Erica Teixeira Pratesteixeiraprae@ornl.gov Uncovering Off-Target Mechanisms of GLP-1R Agonists in Opioid Addiction via AI and Structural Systems Biology
18Francesca Teleseftelese@ucsd.edu Exploring Immature Neurons in the Adolescent Nucleus Accumbens and Their Connection to Cannabis Use
19Rose Sciortinoros4010@med.cornell.edu Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning
20Fatemeh Abdollahy BiroonFAbdollahyBiroon@som.umaryland.edu Exploring the Placental Methylome: Identifying Genetic Markers for Severe Neonatal Opioid Withdrawal Syndrome
21Makeda Turnermakeda.turner@som.umaryland.edu  Investigating Pro-inflammatory Cytokines in Opioid-exposed Pregnancies
22Guy Twagtwa@uab.edu Multiomic profiling reveals cell type-specific chromatin accessibility in the rat nucleus accumbens
23Mudit Tyagimudit.tyagi@jefferson.edu Effect of cocaine, Human Immunodeficiency Virus (HIV) Tat peptide, and antiretroviral drugs on human brain microvascular endothelial cells
24Thomas Vondriskatvondriska@mednet.ucla.edu Chromatin structural proteins as integrators of metabolic, hormonal and biomechanical stress
25Junshi Wangjunshi.wang@mssm.edu Single-cell spatial sequencing and connectomic mapping of the interpeduncular nucleus reveal sex-dependent mechanisms of opioid reward
26Lu Wanglu.wang.lw763@yale.edu Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
27Xu Wangxuwang@temple.edu TLR3 activation of human iPSC-derived brain organoids induces antiviral factors
28Ze Zhong Wangwangzezhong13@gmail.com Studying synaptic transmission under opioid exposure using hiPSC-derived midbrain model and hyperspectral fluorescence lifetime imaging
29Bradley WebbBradley.webb@vcuhealth.org Empirical assessment of substance use disorders phenotype strategies for maximizing genetic discovery power in biobanks
30Jennifer Whistlerjlwhistler@ucdavis.edu Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic voluntary morphine
32Zheng-Xiong Xizxi@intra.nida.nih.gov Dissecting the role of midbrain GABA neurons in cannabinoid reward and aversion using conditional CB1 receptor knockout mice
33Yang Xiaoyangxa@umich.edu Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
34Lei Xielxie@iscb.org Advancing Programmable Human Digital Twins for Substance Use Disorder Drug Discovery
35Eric Xingepxing@cs.cmu.edu FM-Association Analysis: A New Paradigm For Multi-Omic Association Mapping to Complex Clinical Phenotypes
37Huiping Zhanghuipingz@bu.edu Effects of Chronic Intermittent Ethanol (CIE) Exposure on Global m6A RNA Methylation and m6A Regulatory Gene Expression in Mouse Liver
39Xiaoxi Zhuangxzhuang@bsd.uchicago.edu Anti-homeostatic excessive alcohol consumption exacerbated by vitamin B6 deficiency in Drosophila
40Yanning Zuoy3zuo@health.ucsd.edu From Rats to Humans: Revealing Conserved Molecular Networks in Addiction through Gene Expression and GWAS Integration
41Peter Hamiltonpeter.hamilton@vcuhealth.org KZFP function within medium spiny neurons enables molecular and behavioral responses to cocaine
Presenter Unable to Attend
NameEmailAbstract Title
Meghan Chenowethmeghan.chenoweth@utoronto.ca Transcriptome-wide association studies leveraging biomarker data offer etiologic insights into tobacco smoking and schizophrenia
Gabor Egervarigabor@wustl.edu Male Acss2 KO mice exhibit decreased voluntary alcohol intake and blunted ventral striatal chromatin and gene expression changes after drinking
Marsida Kallupimkallupi@health.ucsd.edu Prewired for Addiction: Amygdala GABA Dysregulation Predicts Cocaine Vulnerability
Nadejda Korneevanadejda.korneeva@lsuhs.edu Translation regulation in development of opioid tolerance and hyperalgesia
Patricia Maidana Miguelpatricia.maidanamiguel@mail.mcgill.ca Sex-specific developmental gene networks linking risk-taking behaviors in rodents and humans
Chaitanya Srinivasancsriniv1@andrew.cmu.edu Machine learning prioritization of cell type-specific enhancers in the nucleus accumbens implicated in addiction predispostion

Past Genetic Meeting – May 2024