NIDA Genetic Consortium Meetings & Abstracts

May 2023 Meeting

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Please register for the meeting here: https://apps1.seiservices.com/NIDA/GeneticsConsortium/Registration.aspx

Meeting Dates and Times

  • Tuesday, May 16th: - 9:00 a.m. to 5:30 p.m.
  • Wednesday, May 17th  - 9:00 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

May 16 – Keynote (9:15 am – 9:45 am)
Time First Name Last Name Email Abstract Title
9:15 Andre Toussaint at3658@columbia.edu Understanding Substance Abuse from Scientific and Human Perspectives
May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs
Time First Name Last Name Email Abstract Title
9:45 Kristen Maynard kristen.maynard@libd.org Integrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain
10:00 Marine Salery marine.salery@mssm.edu Capturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens.
10:15 Jennifer Tuscher jtuscher@uab.edu Multiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience
10:30 Benjamin Reiner bcreiner@pennmedicine.upenn.edu Single nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine
May 16 – Special Presentation (11:00 am – 11:10 am)
Time First Name Last Name Email Abstract Title
11:00 Anita Bandrowski bandrow@gmail.com RRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines
May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs
Time First Name Last Name Email Abstract Title
2:00 Carl Lin zlin@mclean.harvard.edu History and Application of Artificial Intelligence: Its Turn for Genomics
2:00 Sara Mostafavi saramos@cs.washington.edu Sequence-based deep learning models for predicting molecular phenotypes
2:15 Hongyang Li Hongyang.Li@ibm.com Asymmetric Predictive Relationships Across Histone Modifications
2:30 Andreas Pfenning apfenning@cmu.edu Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics
May – 16 Session 3 (4:30 pm – 5:20 pm) - Short Talk Presentations
Time First Name Last Name Email Abstract Title
4:30 Alexander Hatoum ashatoum@wustl.edu Multivariate genome-wide assocation meta-analysis of 1 million subjects identifies loci underlying multiple substance use disorders
4:40 Jeffrey Hatfield jshatfi@g.clemson.edu Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel
4:50 Chelsie Benca-Bachman chelsie.benca@emory.edu Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences Among African Americans
4:55 Xiufang (Nadine) Guo xguo@mail.ucf.edu Development of an iPSC-preBötC neuron opiate overdose and recovery multi-organ platform
5:00 Jennifer Kelschenbach jennifer.kelschenbach@mssm.edu Morphine dependence accelerates HIV-associated neurocognitive impairment in EcoHIV infected mice
5:05 Salma Majid majidsn@nih.gov Recurrent and non-recurrent copy number variants in American Indian tribes with substance use disorders
5:10 Freddyson Martinez-Rivera freddyson.martinez-rivera@mssm.edu Cellular and transcriptional contributions of the nucleus accumbens in transferring extinction-based memories
5:15 Evaristus Nwulia enwulia@howard.edu Linking Cannabis Use Disorder, Long-noncoding RNA and Olfactory Structure and Function
May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs
Time First Name Last Name Email Abstract Title
9:00 Elizabeth Heller eheller@pennmedicine.upenn.edu Cocaine regulation of alternative splicing via changes in histone postranslational modifications.
9:15 Zijun Wang zjwang@ku.edu DNA damage and repair processes are involved in opioid addiction
9:30 Zhuzhu Zhang zhuzhuzhang@uchicago.edu Epigenomic remodeling at single cell resolution in cocaine self-administration in mice
9:45 BaDoi Phan badoi.phan@pitt.edu Whole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants
May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs
Time First Name Last Name Email Abstract Title
1:15 Holly Poore holly.poore@rutgers.edu Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30 Sandra Sanchez-Roige sanchezroige@ucsd.edu CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
1:45 Huda Akil akil@umich.edu Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00 Michael Sheldon michael.sheldon@sampled.com Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse
May – 17 Session 6 (4:00 pm – 4:50 pm) - Short Talk Presentations
Time First Name Last Name Email Abstract Title
4:00 Amrit Koirala amrit.koirala@bcm.edu Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10 Vivek Philip Vivek.Philip@jax.org Enumeration and visualization of differential gene co-expression response to cocaine
4:20 Janitza Montalvo-Ortiz janitza.montalvo-ortiz@yale.edu Deciphering the role of DNA hydroxymethylation in substance use disorders
4:25 MadhurBain Singh singhm18@vcu.edu Examining Bidirectional Causal Effects between Smoking and DNA Methylation using Epigenetic Mendelian Randomization Analyses
4:30 Alyssa Wilson alyssa.wilson@mssm.edu Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35 Francesca Telese ftelese@health.ucsd.edu Analysis of single nuclei RNA-seq from the nucleus accumbens of heterozygous reeler mice exposed to THC during adolescence suggests a link between THC exposure, Reelin signaling, and vulnerability to human psychiatric disorders
4:40 Jared Bagley jbagley@binghamton.edu Neuron navigator 1 regulates the self-administration of cocaine
4:45 Laura Saba Laura.Saba@cuanschutz.edu Multi-omic single nuclei data provide insight into the cellular origin of whole brain coexpression patterns related to Oprm1
May 16 – Poster Session A (11:10 am – 12:40 pm)
Poster # First Name Last Name Email Abstract Title
1 Arpana Agrawal arpana@wustl.edu The Psychiatric Genomics Consortium Substance Use Disorders Working Group (PGC-SUD): An Update
2 Schahram Akbarian schahram.akbarian@mssm.edu Single Nucleus Transcriptomic Profiling of Human Ventral Midbrain Reveals Widespread Activation of Multiple Glial Subtype
3 Muhammad Arshad muhammadwaqar.arshad@yale.edu Substance Abuse in Pakistan: Clinical Issues and Research Opportunities
4 Bao-Zhu Yang bao-zhu.yang@yale.edu Inter-Linking the Developmental Brain Transcriptome and GWAS Risk Variants Revealed Neural Circuits Prognostic of Nicotine Use Severity
5 David Ashbrook dashbrook@UTHSC.edu Good wine and old data get better with age: New insights on gene-by-environment effects of drugs of abuse in mice using GeneNetwork.org
6 Christopher Baker christopher.baker@jax.org Genetic variation influences cell specific cis-regulatory landscape in the mouse striatum
7 Madelyn Baker mrb4002@med.cornell.edu Epigenetic representation of cocaine-context association in the dorsal dentate gyrus of male mice
8 Britahny Baskin britty@bu.edu Premorbid addiction model traits and cocaine stimulant sensitivity in spontaneously hypertensive rat (SHR) substrains
9 Jacob Beierle Jacob.Beierle@jax.org A high-throughput machine vision-based univariate scale for pain and analgesia in mice
10 Aritra Bhattacherjee writetoab@gmail.com Decoding molecular organization of the brain reward circuit for understanding mechanisms of drug addiction
11 Chuan Bi chuan.bi@som.umaryland.edu Multivariate Mediation Analysis of Genetic Variants, Brain Connectome and Nicotine Addiction
12 Fatah Kashanchi fkashanc@gmu.edu Retroviral infection of human neurospheres and use of stem cell EVs to repair cellular damage
13 Kasey Brida kbrida@uab.edu Reelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates medium spiny neuron physiology and behavioral response to cocaine
14 Russell Brown BROWN1@mail.etsu.edu Analysis of the enhanced rewarding effects of nicotine and underlying neuroplasticity mechanisms in a heritable model of drug abuse vulnerability in psychosis
15 Caleb Browne caleb.browne@mssm.edu Transcriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
16 Edward Browne epbrowne@email.unc.edu Defining the impact of cannabis use on immune cell phenotypes and the latent viral reservoir in people with HIV.
17 Camron Bryant camron@bu.edu Spectrotemporal USV profiles during neonatal opioid withdrawal in FVB substrains, Zhx2-edited BALB/c substrains, and outbred CFW mice
18 Jason Bubier Jason.Bubier@jax.org A Tale of Two Opioids: The Genetics of Opioid Induced Respiratory Depression in Response to Fentanyl and Morphine in Mice.
19 Belle Buzzi buzzib@vcu.edu Nicotine reward and preference in C57BL/6J and C57BL/6N mouse strains
20 Jean Lud Cadet jcadet@intra.nida.nih.gov Compulsive methamphetamine intake and abstinence in the presence of punishment are associated with differential hydroxymethylation of miRNAs in the rat nucleus accumbens
21 Cali Calarco ccalarco@som.umaryland.edu Mitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine in C57Bl/6 mice
22 Rianne Campbell rcampbell@som.umaryland.edu Baseline Characterizations of Novel D1R-CRISPRa and A2A-CRISPRa Mouse Lines
23 Javan Carter JCarter@rti.org Identifying novel genes and pathways associated with opioid overdose death via meta-analysis of differential gene expression.
24 Samantha Cheeks scheeks@uci.edu Cannabidiol Attenuates Nicotine Self-Administration and Withdrawal Symptomology in Mice
25 Jixin Chen chenj@ohio.edu A single-molecule FRET data fitting package for DNA folding kinetic study
26 Yong Chen chenyong@rowan.edu Inferring Memory-related Regulatory Modules in Engram Cells by Deep-learning and scRNA-seq Data
27 Olivia Corradin corradin@wi.mit.edu Case-specific epigenetic alterations converge on key genes linked to opioid overdose
28 Daniel Wood woodda@musc.edu HDAC5 intrinsic enzymatic activity limits drug-seeking behavior
29 Santiago Cuesta santiago.cuesta@rutgers.edu Gut Microbiota Composition Modulates Cocaine-Induced Neurobehavioral Plasticity
30 Eamonn Duffy Eamonn.Duffy@colorado.edu Characterization of thermal and mechanical sensitivity in select strains of the Hybrid Rat Diversity Panel
31 Soren Emerson soren.d.emerson@vanderbilt.edu Lysine acetyltransferase KAT2a is a novel cocaine-recruited epigenetic regulator in the nucleus accumbens
32 Dan Fabris dan.fabris@uconn.edu Investigating epitranscriptomic communications between HIV-1 infection and neuromodulator response in different CNS cells
33 Fang Fang ffang@rti.org A DNA methylation-based classifier for lifetime cannabis use
34 J. Adam Fields jafields@health.ucsd.edu Effects of cannabinoids on phenotype of patient monocyte-derived macrophages vary by cannabis use patterns
35 Zoe Figueroa zoe.figueroa@email.ucr.edu Astrocytic contributions to chronic methamphetamine induced neuroinflammation and disease
36 Prescilla Garcia-Trevizo pjg5435@psu.edu Long-term Effects of Adolescent Nicotine Exposure on Sensitivity and Cotinine in the Diversity Outbred Mouse Population.
37 Paige Lemen plemen1@uthsc.edu Adolescent Social Isolation Increases Vulnerability to Voluntary Opioid Consumption in Adulthood in Rats
38 Mudit Tyagi Mudit.Tyagi@jefferson.edu Cocaine by co-stimulating NF-kB, NFAT, and AP-1 enhances CD4+ T-cells metabolism; thus, sensitizes partially active cells for HIV infection
39 Min-Ae Song song.991@osu.edu Epigenetic Aging in the Human Lung: Focus on Smoking and Vaping
May 16 – Poster Session B (3:00 pm – 4:30 pm)
Poster # First Name Last Name Email Abstract Title
1 Vivek Swarup vswarup@uci.edu Investigating multi-omic Mechanisms Underlying Opioid Addiction Vulnerability: A Multi-Omics Study
2 Colin Hodgkinson chodg@mail.nih.gov Alcohol and stress additively accelerate epigenetic cellular age
3 Rodrigo Grassi-Oliveira rogo@clin.au.dk Exposomics of Cocaine Use Disorder: A new paradigm to study the impact of environmental exposures in Substance Use Disorders
4 Benjamin Grissom BGrissom@som.umaryland.edu Heroin-induced genomic regulation of ventral pallidum and nucleus accumbens neuron subtypes
5 Petar Grozdanov petar.grozdanov@ttuhsc.edu The role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption
6 Hongsheng Gui hgui1@hfhs.org Bivariate relationship between opioid use disorder and suicide attempts despite mental health
7 Megan Hagenauer hagenaue@umich.edu The Brain Data Alchemy Project: Teaching Research Reproducibility and Discovery Science While Mining Gold from Archived Genomics Data
8 Nikhil Hajirnis nhajirnis@som.umaryland.edu Epigenomic editing of nucleus accumbens neuron subtypes using the CRISPR-Cas12f derived system
9 Peter Hamilton peter.hamilton@vcuhealth.org Synthetic transcription factors, delivered to mouse nucleus accumbens, dysregulate drug-specific transcription and behaviors
10 Shuanglin Hao shao@med.miami.edu Loss of Sirt3 induced by HIV gp120 with morphine in neuropathic pain, is mediated by H3K27me3 in the spinal cord
11 Emily Hartwell Emily.Hartwell@pennmedicine.upenn.edu Performance of a polygenic risk score for depression in a deeply phenotyped sample
12 Ying He yhe@midwestern.edu Epigenetic regulation of opioid dependence by microRNAs
13 Elaine Hebda-Bauer hebda@med.umich.edu Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats
14 Ming-Fen Ho ho.mingfen@mayo.edu Epigenetic Regulation of GABA Catabolism in iPSC-derived Neurons: the Role of FGF21
15 Leanne Holt leanne.holt@mssm.edu Elucidation of the astrocyte-specific transcriptome following cocaine self-administration
16 Spencer Huggett shuggett91@gmail.com In Silico Genetic & Neuromolecular Drug Repurposing for Opioid Use Disorder
17 Alvin Jeffery alvin.d.jeffery@vanderbilt.edu Detecting Opioid Use Disorders in the Electronic Health Record to Support Genetic Studies: Adaptation of the Addiction Behaviors Checklist
18 Thomas Jhou jhou@musc.edu Heritability and GWAS analyses of punishment sensitivity and cocaine avoidance in HS rats
19 Kan Shao kshao@indiana.edu Dose-Response Analysis to Advance Gene and Pathway Identification for Risk Estimation of Substance Use Disorder
20 Guochun Jiang jianggc@gmail.com Epigenetic regulation of a persistent HIV reservoir in human brain myeloid cells despite durable ART
21 Emma Johnson emma.c.johnson@wustl.edu Cross-disorder analysis of cannabis use disorder and schizophrenia reveals convergent and divergent genetic influences
22 Yonwoo Jung yonwoo.jung@nih.gov Mitochondrial Dysfunction and Oxidative Stress: Conserved Functional Phenotypes in Cocaine Addiction across Multiple Brain Regions
23 Marcus Kaul Marcus.Kaul@medsch.ucr.edu Methamphetamine promotes in macrophages stimulated with LTR mimic ssRNA40 expression of HIV-regulating lncRNA HEAL and pro-inflammatory factors but suppresses the interferon response
24 Panjun Kim pkim11@uthsc.edu 3D Chromatin Interaction Data Facilitates de novo Genome Assembly and Identifies Promoter-Enhancer Interaction in the PFC of Rats
25 Cassandra Kooiker ckooiker@uci.edu Genetic tagging uncovers a role for the thalamic paraventricular nucleus in mediating aberrant reward behaviors following adverse experiences early in life
26 Brittany Kuhn kuhnb@musc.edu Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
27 Ashley Kumar avkumar@ucsd.edu Transcriptional initiation profiling of primary brain cells to study stimulus-dependent enhancer activity
28 Valeria Lallai vlallai@uci.edu THC- and Nicotine-Induced Changes in Central and Peripheral Extracellular Vesicle RNA Cargo
29 Eva Lancaster Eva.Lancaster@vcuhealth.org Examining polygenic risk score by environment interaction on the relationship between interpersonal violence exposure and alcohol use in an ancestrally diverse college cohort
30 Paige Lemen plemen1@uthsc.edu Opiate responses are controlled by interactions of Oprm1 and Fgf12 loci in rodents: Correspondence to human GWAS findings
31 Michael Leone mleone@andrew.cmu.edu Spinal cord neuronal subtypes conserved across species are genetically implicated in chronic pain disorders
32 Dongmei Li Dongmei_Li@urmc.rochester.edu Longitudinal changes in expression profile of urine exosomal epigenetic microRNAs in exclusive electronic cigarette adult users
33 Xiaoyu Liang xiaoyuliang@msu.edu DNA Methylation-Based Telomere Length Is Associated With HIV Frailty and All-Cause Mortality
34 Carl Litif clitif@uwyo.edu Identifying reward-specific transcriptomes underlying polyreward seeking ensembles in the nucleus accumbens core and prelimbic cortex
35 Shirelle Liu liu00459@umn.edu Differential gene expression and epigenetic regulation in the medial prefrontal cortex of rats showing vulnerability to opioid addiction
36 Jennifer Loftis loftisj@ohsu.edu Plasma extracellular vesicles and their miRNA cargo as biosignatures for neuropsychiatric impairments in methamphetamine use disorders
37 Ryan Logan Ryan.Logan@umassmed.edu Elevated DNA damage and inflammatory markers in specific striatal cell types associated with opioid use disorder using single nuclei RNAseq in human postmortem brain
38 Falk Lohoff falk.lohoff@nih.gov Additive Effects of Stress and Alcohol on Epigenetic Aging
39 Samikkannu Thangavel thangavel@tamu.edu Epigenetic signature of N-terminal acetyltransferases role in HIV-Neuropathogenesis
May 17 – Poster Session C (10:15 am – 11:45 am)
Poster # First Name Last Name Email Abstract Title
1 Alice Min Alice.Min@mountsinai.org A novel humanized mouse model to track active and latent CNS HIV-1 infection and to test therapeutic interventions
2 Luis Araujo ldearaujo@unimelb.edu.au Power, measurement error and pleiotropy robustness in twin design extensions to Mendelian randomization
3 Paige Lemen plemen1@uthsc.edu Oxycodone oral self-administration in inbred rats identifies different patterns of vulnerability
4 Andrew Lombardi anlo5057@colorado.edu Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
5 Shahrdad Lotfipour shahrdadlotfipour@me.com Functional Role of a Human 3'UTR Alpha6 Nicotinic Receptor Polymorphism (rs2304297) in Adolescent Substance Use
6 Qing Lu lucienq@ufl.edu Kernel Neural Networks for Analyzing Large-scale Substance Use Disorders Genetic Data
7 William Lynch wlynch@bu.edu Validating Zhx2 in oxycodone metabolite (oxymorphone) brain concentration and behavior via reciprocal gene editing and viral manipulation of gene expression in BALB/c substrains
8 Tianzhou Ma tma0929@umd.edu Bayesian indicator variable selection for multivariate response with application to multi-trait fine mapping
9 Scott Mackey msmackey@uvm.com ENIGMA Addiction: Neuroimaging Biotypes Supported by Gene Enrichment Analysis
10 Rajtarun Madangopal rajtarun.madangopal@nih.gov In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
11 Travis Mallard tmallard@mgh.harvard.edu Limited evidence for a general dimension of impulsivity across genomic, transcriptomic, and neuroanatomical levels of analysis
12 Lisa Maturin lmaturin@health.ucsd.edu The Addiction Biobanks: : Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
13 Nicola Micali nicola.micali@yale.edu The effect of prenatal cannabinoid exposure on developing primate cerebrum
14 Melyssa Minto mminto@rti.org Tissue-Specific DNA Methylation Signatures of Alcohol Use Disorder in Human Brain
15 Suzanne Mitchell mitchesu@ohsu.edu Lessons learned in creating selected lines for high and low delay discounting
16 Mahesh Mohan mmohan@txbiomed.org Delta-9-Tetrahydrocannabinol:Cannabidiol combination counteracts colonic epithelial and blood-brain barrier dysfunction in SIV-infected rhesus macaques on combination anti-retroviral therapy
17 Kateryna Murlanova kmurlano@buffalo.edu Loss of astrocytic mu opioid receptors exacerbates aversion associated with morphine withdrawal in mice: a role for mitochondrial respiration
18 Randy Nelson randy.nelson@hsc.wvu.edu Light at Night Drives Sex-Specific Increases in Fentanyl Reward-Related Behaviors
19 Abraham Palmer aap@ucsd.edu RATTACA: a new paradigm for examining genetic correlations in outbred rats
20 Rohan Palmer Rohan.Palmer@Emory.edu Conserved Co-expression Signatures of Chronic Alcohol Consumption across Species
21 Clarissa Parker cparker@middlebury.edu Genetic variation and heritability of negative affective withdrawal from cocaine in the CC/DO founder mouse strains
22 Gita Pathak gita.pathak@yale.edu Epigenetic profiles of latent classes for polysubstance use disorder
23 Jack Pattee jack.pattee@cuanschutz.edu Adjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organisms
24 Qian Peng qpeng@scripps.edu Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations
25 Inga Peter inga.peter@mssm.edu High Content Transcriptomics Screen to Explore Pathway Crosstalk between Morphine and Antiretroviral Therapy Drug Combinations
26 Amanda Gentry Amanda.Gentry@vcuhealth.org Machine Learning to Predict Alcohol Consumption From Blood-Based Biomarkers
27 Robert Phillips rphill3@uab.edu Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
28 Bryan Quach bquach@rti.org Transcriptome-wide association study for frequent cocaine use identifies gene dysregulation in CD4+ T cells linked to immune response and cancer pathways
29 Fatir Qureshi qureshi@wi.mit.edu Chromatin QTL analysis identifies genetic variants that influence H3K27ac in opioid overdose cases.
30 Yumna Rahman rahmany@vcu.edu Influence of Genotype and Sex on Oral Nicotine Consumption in Founder Strains of Diversity Outbred Mice
31 Hannah Ramcharan hkramcha@wi.mit.edu Variation in Gene Regulation Across Neurons from Seven Different Brain Regions
32 David Root David.Root@Colorado.EDU Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
33 Adrian Rothenfluh adrian.rothenfluh@hsc.utah.edu Bitter gustatory perception protects Drosophila from escalating cocaine consumption preference.
34 Erick Saldes esaldes@miners.utep.edu Novel genetic loci interacting with social environment for dysfunctional inhibitory control
35 Danielle Sambo danielle.sambo@nih.gov Differential effects of prenatal alcohol exposure on brain growth in a mouse model for fetal alcohol spectrum disorder
36 Yasmine Sami yns@wi.mit.edu Differentially expressed genes in Opioid Use Disorder are enriched amongst genes with brain region specific regulatory activity
37 Jiangwen Sun jsun@odu.edu Training Deep Neural Networks Predicting DNA Methylation to Elucidate Genetic Associations in Substance Use Disorders
May 17 – Poster Session D (2:30 pm – 4:00 pm)
Poster # First Name Last Name Email Abstract Title
1 Sandra Sanchez-Roige sanchezroige@ucsd.edu Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
2 Pietro Sanna psanna@scripps.edu Unraveling the interplay between neuroHIV and substance abuse with systems biology to shed light on novel druggable targets.
3 Katherine Savell katherine.savell@nih.gov Development of multipleXed Population Selection and Enrichment single nuclei RNA-sequencing (XPoSE-seq) to characterize neuronal ensembles in cocaine relapse
4 Randal Alex Serafini alex.serafini@icahn.mssm.edu Novel Oxycodone Paradigm Highlights Mesocorticolimbic Mechanisms Underpinning Withdrawal-associated Behaviors with and without Chronic Pain
5 Marit Solheim-Witt marit@alpha-element.com Resilience, resourcefulness and self-leadership: Evaluation of a self-management program and novel conceptual framework of Vitality Type patterns in behavior and communication
6 Akhil Sharma akhilsharma@wayne.edu Comparing Responses of the Nucleus Accumbens and Ammon’s Horn to Methamphetamine Neurotoxicity
7 Aliaksandra Sikirzhytskaya sikirzha@mailbox.sc.edu AI-based mining of biomedical literature: Applications for the drug repurposing for the treatment of HIV-Associated Neurocognitive Disorder.
8 Omar Soler-Cedeño omar.soler-cedeno@nih.gov Brain CB2 receptor: a new therapeutic target for treating opioid use disorders, major findings from a new CB2-KO-eGFP reporter mouse line
9 Sheetal Sreeram sxs2286@case.edu Induced pluripotent stem cells (iPSCs) derived cerebral organoids to model the impact of methamphetamine exposure on HIV latency.
10 Chaitanya Srinivasan csriniv1@cs.cmu.edu Regulatory variation in D1/D2 co-expressing medium spiny neurons is suggested to predispose addiction-related traits
11 Jerry Stitzel stitzel@colorado.edu QTL Mapping of Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
12 Kyle Sullivan sullivanka@ornl.gov Heroin overdose-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABAergic interneurons and provide insight into cell type-specific regulatory response
13 Jiangwen Sun jsun@odu.edu Annotating Genetic Variants by Training Deep Neural Networks to Predict Multiple Epigenomic Events in Brain via Effective Multi-task Learning
14 Makoto Taniguchi Taniguch@musc.edu A long non-coding enhancer RNA regulates NPAS4 in the NAc to control drug reward-conditioned behavior
15 Lisa Tarantino lisat@med.unc.edu Genetic mapping of initial locomotor sensitivity to cocaine in two divergent Collaborative Cross inbred mouse strains
16 Iris Titos iris.titos@utah.edu Mechanisms of diet modulating experience-dependent amphetamine preference
17 Jill Turner Jill.Turner@uky.edu Phenotyping Individual Differences in Escalation of Fentanyl Self-Administration in Sprague-Dawley Rats. 
18 David Vandenbergh djv4@psu.edu Hyper-Variable Number of Tandem Repeats in Intron 8 of the Human Dopamine Transporter Gene (SLC6A3)
19 Arvind Venkataraman avenkata@uw.edu A genome-wide association study of methamphetamine use among people with HIV
20 Thiago Viola thiago.wendt.viola@gmail.com The effects of maternal cocaine use during pregnancy in pediatric epigenetic clocks and methylation risk scores in humans
21 Lu Wang lu.wang.lw763@yale.edu Whole-exome Sequencing Study of Alcohol Use Disorder in 1,668 European Americans and 1,547 African Americans
22 Xu Wang xuwang@temple.edu Activation of Toll-like receptor 3 by poly (I:C) inhibits HIV infection of human iPSC-derived microglia
23 Tao Wu Tao.Wu@bcm.edu Quantitative Profiling of DNA N6-methyladenine at single-base resolution with NAME-Seq
24 Sarah Neal sjneal@mdanderson.org A Baboon Research Resource for Use in Studies on Substance Abuse Disorders
25 Julie White jdwhite@rti.org Integration of DNA methylation and RNA sequencing elucidates differential gene regulation associated with alcohol use disorder in the human brain
26 Anastasia Williams awill57@gmu.edu The effects of cannabidiol and HU308 on viral transcription in HIV-1 infected cells and resulting extracellular vesicle release
27 Caryn Willis cdwillis@rti.org Gene Correlation Networks Replication Analysis Across Studies to Identify Top Candidate Gene Targets in Opioid Use Disorder
28 Michael Wyatt wyatt@cop.sc.edu Drug Repurposing for the prevention of dementia among people living with human immunodeficiency virus: A focus on the renin-angiotensin system
29 Rong-Guang Xu roxu@bwh.harvard.edu How histone post-translational modifications impact nucleosome structure and accessibility: A molecular dynamics study
30 Gal Yadid yadidg@mail.biu.ac.il Use of psychedelic and epigenetic substances as novel approaches for treating substance addiction – hope or hype?
31 Zhenyao Ye zye@som.umaryland.edu Pleiotropic genes for resting-state brain functional connectivity and nicotine addiction
32 Hang Zhou hang.zhou@yale.edu Mendelian Randomization Analysis of the Effects of Alcohol Use on Cancer Risk
33 Yanjiao Zhou yazhou@uchc.edu Genetic control of the microbiome and bile acids to influence addiction-related behaviors
34 Laura Hack hack@stanford.edu Ketamine’s Acute Effects on Negative Brain States are Mediated through Distinct Altered States in Humans
35 Yanchao Pan hanyou@umich.edu A revamped rat reference genome improves the discovery of genetic diversity of laboratory rats
Abstracts From Those Unavailable to Present
First Name Last Name Email Abstract Title
Li-Shiun Chen li-shiun@wustl.edu Roadmap for translating genomic evidence to clinical interventions for prevention and treatment
Ditte Demontis ditte@biomed.au.dk Elucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS
Desmond Smith DSmith@mednet.ucla.edu Cocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice

Past Genetic Meetings are available on the Archives site