NIDA Genetic Consortium Meetings & Abstracts | National Institute on Drug Abuse (NIDA)

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 23-24, 2024 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Registration and Meeting support information

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May 23 - Session 1 Concurrent Panels (9:30–10:45 a.m.) SCORCH Consortium: Single-cell Approaches to Define Intersections Between Substance Use Disorders and HIV Infection
Chair: Paul Kenny, Ph.D., Icahn School of Medicine at Mount Sinai
Time	First Name	Last Name	Email	Abstract Title
9:15 a.m. - 9:30 a.m.	Alejandra	Borjabad	Alejandra.Borjabad@mssm.edu	HIV infection enhances the addiction-related actions of opioids: Brain substrates and cellular mechanisms
9:30 a.m. - 9:45 a.m.	Dong-Wook	Kim	dongwook.kim@alleninstitute.org	Characterization of Single cell multiomic changes during chronic HIV infection and cocaine self-administration in mice
9:45 a.m. - 10:00 a.m.	Brian	Herb	bherb@som.umaryland.edu	Comparative single-cell multi-omic atlases of molecular adaptations associated with substance use and HIV infections in the prefrontal cortex and nucleus accumbens of humans, non-human primates, and rodents
10:00 a.m. - 10:15 a.m.	Raleigh	Linville	linville@mit.edu	Cellular taxonomy of the human and mouse striatum defines novel neuronal subtypes in opioid and antipsychotic action

The ABCD Study - A Rich Resource for Genetic and Epigenetic Research on the Predictors of Substance Use
Chairs:
Kimberly LeBlanc, Ph.D., National Institute on Drug Abuse
Pamela Madden, Ph.D. Washington University in St. Louis.
Time	First Name	Last Name	Email	Abstract Title
9:15 a.m. - 9:30 a.m.	Robert	Loughnan	rloughnan@ucsd.edu	Opportunities and Challenges in Studying Genetic Risk for Substance Abuse in the ABCD Study
9:30 a.m. - 9:45 a.m.	Hermine H.	Maes	hermine.maes@vcuhealth.org	Estimating twin heritability and environmental sources of variation in the ABCD Study.
9:45 a.m. - 10:00 a.m.	Jill	Rabinowitz	jr1919@rutgers.edu	Associations of Neural and Genetic Characteristics with Substance Use Risk in the Adolescent Brain Cognitive Development Study
10:00 a.m. - 10:15 a.m.	Alexander	Hatoum	ashatoum@wustl.edu	2.) Phenome Wide Association Study of Polygenic Risk Scores for Substance Use Disorders in The Adolescent Brain and Development Study

May 23 – Session 2 Concurrent Panels (1:45–3:00 p.m.) Leveraging the All of Us Biobank to Make Strides In Substance Use Disorder Genomics Research
Chairs:
Arpana Agrawal, Ph.D., Washington University in St. Louis
Daniel Jacobson, Ph.D., Oak Ridge National Laboratory
Time	First Name	Last Name	Email	Abstract Title
1:45 p.m. - 2:00 p.m.	Janitza L.	Montalvo-Ortiz	janitza.montalvo-ortiz@yale.edu	Accelerating psychiatric genetics research in Latin American populations: Consortia efforts and Novel findings
2:00 p.m. - 2:15 p.m.	Peter	Barr	peter.barr@downstate.edu	The impact of social and genetic risk factors on the onset of comorbid problems in persons with substance use disorders.
2:15 p.m. - 2:30 p.m.	Emma	Johnson	emma.c.johnson@wustl.edu	1.) Phenotypic and genomic relationships between chronic pain and substance use disorders in the All of Us biobank
2:30 p.m. - 2:45 p.m.	Rodney	Gabriel	ragabriel@health.ucsd.edu	Predicting Development of Opioid Use Disorder Among Chronic Pain Patients Using Genomics, Social, and Clinical Factors within the All of Us Research Dataset

Understanding the Role of NAc in Substance Use Disorder (SUD) Beyond the D1 and D2 Level
Chairs:
Yi Zhang, Ph.D., Boston Children's Hospital
Veronica Alvarez, Ph.D., National Institute of Mental Health
Time	First Name	Last Name	Email	Abstract Title
1:45 p.m. - 2:00 p.m.	Yi	Zhang	yzhang@genetics.med.harvard.edu	Identifying and characterizing neuron subtypes and circuits regulating SUD
2:00 p.m. - 2:15 p.m.	Mary Kay	Lobo	mklobo@som.umaryland.edu	Cell subtype transcriptional programs in cocaine intake and seeking behavior
2:15 p.m. - 2:30 p.m.	Ana-Clara	Bobadilla	ac.bobadilla@colostate.edu	Differential genetic expression within reward-specific ensembles in mice
2:30 p.m. - 2:45 p.m.	Veronica A.	Alvarez	alvarezva@mail.nih.gov	Transcriptomic Landscape of Compulsive-like Alcohol Drinking

May 23 – Short Talk Session 1 (3:00–4:00 p.m.)
Time	First Name	Last Name	Email	Abstract Title
3:00 p.m. - 3:05 p.m.	Elissa	Chesler	Elissa.Chesler@jax.org	Integrative mouse genetic analysis illuminates human GWAS of multiple substance use.
3:05 p.m. - 3:10 p.m.	Michael	Garvin	garvinmr@ornl.gov	Genetic Loci Associated with Cocaine Use Identified using Novel Approach to Detect Epistasis
3:10 p.m. - 3:15 p.m.	Vivek	Kumar	Vivek.Kumar@jax.org	Forward genetic screen of the KOMP2/IMPC resource identifies addiction mutants
3:15 p.m. - 3:20 p.m.	Zhana	Duren	zduren@clemson.edu	Inferring gene regulatory networks from single cell multiome data using atlas-scale external data
3:20 p.m. - 3:25 p.m.	John	Hernandez	john_hernandez@brown.edu	Single nuclei transcriptomics of the Drosophila mushroom body
3:25 p.m. - 3:30 p.m.	J Spencer	Hatfield	jshatfi@clemson.edu	Genome-wide Association Analysis of Cocaine Preference in Drosophila
3:30 p.m. - 3:35 p.m.	Sergei	Grigoryev	sag17@psu.edu	Cryo-electron tomography reveals the inner structure of nucleosome condensates in chromatin of epigenetically modified mouse retina
3:35 p.m. - 3:40 p.m.	Andy	Chen	andychen@iu.edu	Functional Screening of Regulatory Variants Combined with Genome-wide Association and Machine Learning Identifies Causal Regulatory Mechanisms Impacting Substance Use Disorders
3:40 p.m. - 3:45 p.m.	Chen	Fu	chen.fu@umassmed.edu	Association between elevated markers of DNA damage and higher frequency of somatic mutations in neurons in opioid use disorder
3:45 p.m. - 3:50 p.m.	Olivier	George	olgeorge@health.ucsd.edu	Identification of gene variants that predict cocaine addiction-like behaviors in heterogeneous stock rats

May 24 - Session 3 Concurrent Panels (9:05–10:20 a.m.) RNA-binding Proteins and Post-transcriptional Gene Regulation in Addiction Disorders
Chairs:
Duan Liu, Ph.D., Mayo Clinic
Yunlong Liu, Ph.D., Indiana University
Time	First Name	Last Name	Email	Abstract Title
9:35 a.m. - 9:50 a.m.	Yunlong	Liu	yunliu@iu.edu	Roles of alternative splicing in alcohol use disorder
9:05 a.m. - 9:20 a.m.	Duan	Liu	liu.duan@mayo.edu	Neuron-specific RNA-binding Protein ELAVL2 and Post-transcriptional Gene Regulation in Substance Use Disorders
9:20 a.m. - 9:35 a.m.	Huiping	Zhang	huipingz@bu.edu	RNA N6-methyladenosine modifications in the mesolimbic dopamine system of subjects with alcohol use disorder
9:50 a.m. - 10:05 a.m.	Katie	Rothamel	krothamel@health.ucsd.edu	Advancing RBP Research: Scalable Tools for Protein-RNA Interaction Analysis

Computational Approaches Analyzing Big Healthcare Data Using Machine Learning And Other Tools To Identify Genetic, Phenotypic Risk Factors And Potential Medication Treatments For Substance Use Disorders or Co-Occurring Mental Health Conditions
Chairs:
Udi Ghitza, Ph.D., National Institute on Drug Abuse
Susan Wright Ph.D., National Institute on Drug Abuse.
Time	First Name	Last Name	Email	Abstract Title
9:05 a.m. - 9:20 a.m.	Rong	Xu	rxx@case.edu	Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses
9:20 a.m. - 9:35 a.m.	Roy	Perlis	RPERLIS@mgh.harvard.edu	Uses and misuses of machine learning for electronic health records
9:35 a.m. - 9:50 a.m.	Alexander	Hatoum	ashatoum@wustl.edu	3.) Machine learning Predictors of Substance Use disorder using Genetics Need Control for Ancestry
9:50 a.m. - 10:05 a.m.	Travis	Mallard	tmallard@mgh.harvard.edu	Characterizing the Genetic Architecture of Impulsivity and its Overlap with Substance Use and Psychopathology

May 24 – Session 4 Concurrent Panels (1:15–2:30 p.m.) Novel Methodologies to Untangle Transcriptional and Epigenetic Underpinnings of Substance Use Disorder.
Chairs:
Eric Nestler, M.D., Ph.D., Icahn School of Medicine at Mount Sinai
Ian Maze, Ph.D., Icahn School of Medicine at Mount Sinai
Time	First Name	Last Name	Email	Abstract Title
1:15 p.m. - 1:30 p.m.	Alexander	Smith	smitaw@musc.edu	A master regulator of opioid reward in ventral prefrontal cortex
1:30 p.m. - 1:45 p.m.	Tamara	Markovic	tamara.markovic@mssm.edu	Modulating levels of ∆FOSB alters nucleus accumbens medium spiny neurons activity to salient stimuli.
1:45 p.m. - 2:00 p.m.	Sasha	Fulton	slf2127@columbia.edu	Multi-omic single-nucleus characterization of orbitofrontal cortex after cocaine self-administration
2:00 p.m. - 2:15 p.m.	Kristen	Maynard	Kristen.maynard@libd.org	Multi-omic approaches for molecular mapping of reward circuitry in the human brain

Decoding the Web of Addiction: A Systems Biology and Network Analysis Perspective
Chairs:
Olivia Corradin, Ph.D., Massachusetts Institute of Technology
Sulggi Lee, M.D., Ph.D., University of California, San Francisco
Time	First Name	Last Name	Email	Abstract Title
1:15 p.m. - 1:30 p.m.	Julia (Kate)	Brynildsen	jbryn@seas.upenn.edu	Gene coexpression patterns predict opiate-induced brain-state transitions
1:30 p.m. - 1:45 p.m.	Ming-Fen	Ho	ho.mingfen@mayo.edu	Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
1:45 p.m. - 2:00 p.m.	Susan	Ribeiro	susan.pereira.ribeiro@emory.edu	Methamphetamine Use in People with HIV on Antiretroviral Therapy is Associated with Elevated Systemic Inflammation and HIV Reservoir Transcription
2:00 p.m. - 2:15 p.m.	Bo	Zhang	bzhang29@wustl.edu	Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats

May 24 – Short Talk Session 2 (4:00–5:00 p.m.)
Time	First Name	Last Name	Email	Abstract Title
4:00 p.m. - 4:05 p.m.	Rahul	D'Mello	dmello@ohsu.edu	Prenatal THC Exposure Alters the Offspring Methylome, Neurodevelopment, and Emotional Behavior
4:05 p.m. - 4:10 p.m.	Anna	Leonard	anna.leonard@pennmedicine.upenn.edu	Alternative splicing in a mouse model of Oprm1 A118G
4:10 p.m. - 4:15 p.m.	Alice K.	Min	alice.min@mountsinai.org	Genetically Modified Human iPSC-Derived Microglia in a Chimeric Mouse Model for Studying CNS HIV-1 Infection and Drug Use
4:15 p.m. - 4:20 p.m.	Dongbing	Lai	dlai@iu.edu	Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations
4:20 p.m. - 4:25 p.m.	Nana	Amissah	nanaamis@buffalo.edu	Genome wide association studies in heterogeneous stock rats identify links between cue-reactivity and cocaine motivation.
4:25 p.m. - 4:30 p.m.	Jason	Bubier	Jason.Bubier@jax.org	One of these things is not like the others: Genetic Variation in Morphine and Fentanyl Response in Mice.
4:30 p.m. - 4:35 p.m.	Drew D.	Kiraly	dkiraly@wakehealth.edu	Gut-brain signaling as a modulator of brain chromatin structure and gene expression in models of substance use disorder.
4:35 p.m. - 4:40 p.m.	Ying-Xian	Pan	yx.pan@rutgers.edu	2.) Mitigating adverse side effects of clinically used mu opioids by targeting exon 7-associated splice variants of the mu opioid receptor gene, Oprm1, without altering mu opioid analgesia in pain management

May 23 – Poster Session A (10:45 a.m.–12:15 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Hannah	Alton	hannah.alton@nih.gov	Revisiting the cannabinoid-opioid interaction hypothesis using conditional CB1 and µ opioid receptor knockout mice
2	Bradley E.	Aouizerat	bea4@nyu.edu	Piercing the veil of how substance use negatively impacts comorbidities in HIV
3	Babak	Baban	bbaban@augusta.edu	Epigenetic effects on substance abuse through immune re-modelling
4	Svitlana V.	Bach	svitlana.bach@libd.org	Molecular profiling of the human nucleus accumbens with spatial and single nucleus resolution
5	Jared	Bagley	jbagley@binghamton.edu	Polygenic risk for extreme cocaine intake associates with larger dopaminergic responses to cocaine in the nucleus accumbens of BXD inbred mice
6	Ludmila	Bakhireva	lbakhireva@salud.unm.edu	Diagnostic Utility of miRNA Signature in Umbilical Cord Blood for Identification of Severe Neonatal Opioid Withdrawal Syndrome
7	Britahny M.	Baskin	b.baskin@northeastern.edu	Spontaneously Hypertensive Rat substrains and the offspring of reciprocal F2 crosses exhibit differences in addiction risk traits and cocaine behavioral sensitivity
8	Malia	Bautista	maliarb@uci.edu	The Missing Lynx: The Role of Lynx2 in Nicotine Relapse
9	Andrew W.	Bergen	awbergen2@gmail.com	Stable Methadone Dose, Toxicology & Treatment Retention in New Jersey MAT
10	Aritra	Bhattacherjee	Aritra.Bhattacherjee@childrens.harvard.edu	A molecularly and spatially defined prefrontal cortical circuit regulating drug relapse
11	Jennifer	Blackburn	Jennifer.blackburn@yale.edu	Multiplex Cytokine Profiling and Single Nuclei RNAseq Reveal Anti-Inflammatory Changes Following Intravenous Δ-9 Tetrahydrocannabinol Administration Among Healthy Participants
12	Kenneth	Blum	drd2gene@Gmail.com	Preaddiction Phenotype is Associated with Dopaminergic Dysfunction: Pharmacogenomic Evidence from 88.8M GWAS-Based Samples
13	Kasey	Brida	kbrida@uab.edu	Reelin regulates striatal excitability & cocaine reward
14	Russell W.	Brown	brown1@etsu.edu	Underlying Mechanisms of the Effects of Nicotine in a Heritable Model of Drug Abuse Vulnerability in Psychosis
15	Jason	Bubier	Jason.bubier@jax.org	Host genetics, microbiome composition and addiction/addiction-related behavior in mice
16	Cali	Calarco	ccalarco@som.umaryland.edu	Regulation of gene expression in striatal input regions by cocaine self-administration
17	Rianne	Campbell	rcampbell@som.umaryland.edu	Cocaine-induced Changes in Gene Expression and Regulation within GABAergic Ventral Pallidum Cell Types
18	Nazzareno	Cannella	nazzareno.cannella@unicam.it	Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in NIH Heterogeneous Stock rats.
19	Lieselot	Carrette	lcarrette@health.ucsd.edu	Characterization of the whole-brain reactivity and functional connectome associated with analgesia through MOR and KOR agonism.
20	Luis FS	Castro-de-Araujo	luis.araujo@vcuhealth.org	Dynamic Growth of ADHD Symptoms in Youth: Estimating Variance Components of Latent Growth Factors and their Associations with Genetic Liabilities to Substance Use and Abuse
21	Samar Nasser	Chehimi	samar.chehimi@pennmedicine.upenn.edu	Fentanyl-xylazine interaction induces transcriptional modifications in the nucleus accumbens of Sprague Dawley rats
22	Hao	Chen	hchen@uthsc.edu	1.) Sex and heredity are determinants of oral oxycodone self-administration in 36 Inbred Rat Strains: correlations with behavioral tests of anxiety and novelty-seeking
23	Laurens	Holmes, Jr.	lholmes@desu.edu	1.) DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) Implication in Substance Use Disorders (SUD) in Essential Hypertension
24	Youshu	Cheng	youshu.cheng@yale.edu	A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data
25	Meghan	Chenoweth	meghan.chenoweth@utoronto.ca	Sex-Dependent Genetic Architecture of Tobacco-Related Biomarkers
26	Richard	Crist	crist@pennmedicine.upenn.edu	Single nucleus ATAC-seq of the central amygdala reveals patterns of chromatin accessibility associated with the cocaine self-administration rats
27	M. Imad	Damaj	m.damaj@vcuhealth.org	Genetic Variation in nicotine withdrawal in mice using reduced complexity cross
28	Giordano	de Guglielmo	gdeguglielmo@health.ucsd.edu	Exploring Genetic Influences on Alcohol Use Disorder: A Comprehensive Study of Addiction-like Behaviors in Heterogeneous Stock Rats
29	Danielle	Dick	danielle.m.dick@rutgers.edu	Characterizing Addiction Risk Across Development in Large Epidemiological and Population-Based Samples
30	Scott R.	Diehl	scott.diehl@rutgers.edu	Strain Differences in Susceptibility to Opioid Side Effects In Female Mice
31	Eamonn	Duffy	Eamonn.duffy@colorado.edu	Sex and genetic background influence intravenous oxycodone self-administration in the Hybrid Rat Diversity Panel
32	Fang	Fang	ffang@rti.org	Exposure- and genetically driven epigenetic associations with lifetime cannabis use.
33	Zoe	Figueroa	zfigu001@ucr.edu	Inflammation driven astrocyte responses during neuroinflammation caused by chronic methamphetamine exposure
34	Heidi S.	Fisher	heidi.fisher@jax.org	Identification of strain differences in transcriptional responses to cocaine across stages of drug self-administration in mice with high and low rates of acquisition and extinction
35	Bryan C.	Quach	bquach@rti.org	Transcriptomic analyses identify genes mediating frequent cocaine use effects on HIV latent reservoir quantity

May 23 – Poster Session B (4:00–5:30 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Xiao-Bing	Gao	xiao-bing.gao@yale.edu	Transcriptomic study reveals changes in gene expressions in the lateral hypothalamic area in socially isolated mice: relevance to drug addiction
2	Ivy	Garrenton	igarr001@odu.edu	Dissecting the Etiology of Alcohol Use Disorder by an Integrative Heritable Component Approach
3	Henri M.	Garrison-Desany	hgarrisondesany@hsph.harvard.edu	Association of cord blood DNA methylation patterns and scores with prenatal exposure to opioids, cannabis, and polysubstances
4	Emma	Gnatowski	gnatowskie@vcu.edu	Mechanisms of Ethanol Anxiolysis: Role of Global Ninein Deletion On Ethanol and Anxiety-Like Behaviors.
5	Mikah	Green	mikah.green@som.umaryland.edu	Using a Cas1sf derived system for CRISPR epigenome editing of fentanyl regulated hub genes.
6	Nick	Green	greenni@iu.edu	Cell Type-specific Changes in the Caudate Nucleus of Human Postmortem Brains Induced by Alcohol Use Disorder
7	Benjamin H.	Grissom	Bgrissom@som.umaryland.edu	A single-cell multi-omic atlas of the ventral pallidum reveals VGLUT1 neuron-specific transcriptional responses in immediate and prolonged forced abstinence from heroin self-administration
8	Hongsheng	Gui	hgui1@hfhs.org	Integrative Omics for studying opioid use disorder and suicidality in African Americans
9	Peter	Hamilton	Peter.Hamilton@vcuhealth.org	The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations
10	Elaine K.	Hebda-Bauer	hebda@med.umich.edu	The Hippocampus and Nucleus Accumbens Show Unique and Shared Gene Expression Patterns in a Selectively Bred Rat Model of Contrasting Temperaments that Impact Drug Use
11	Hao	Chen	hchen@uthsc.edu	2.) Genetic Association of Socially Acquired Nicotine Self-administration in Adolescent Outbred Rats Identifies Candidate Genes Shared with Human Smoking GWAS
12	Laurens	Holmes, Jr.	lholmes@desu.edu	2.) Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Substance Use Disorder (SUD) Implicated in Early Life Stress and Major Depressive Disorder (MDD) Correlation
13	Leanne	Holt	leanne.holt@mssm.edu	Astrocytic CREB regulates the transcriptional and behavioral responses to cocaine.
14	Christian	Hopfer	Christian.Hopfer@cuanschutz.edu	Using RNA expression from immune-related cell types in blood to better understand potential influences of THC and CBD on human health
15	Chukwudike	Igwe	chigwe@iu.edu	Is Gm22068 a novel epitranscriptomic marker for thirdhand vaping exposure?
16	Daniel A.	Jacobson	jacobsonda@ornl.gov	Integrating Multi-Omics Data through Multiplex Networks: A Novel Team Science-based Framework for Understanding the Mechanisms Underpinning Substance Use Disorders and Comorbid Neuropsychological Conditions
17	Changhoon	Jee	cjee1@uthsc.edu	Positive reinforcement produced by stimulation of dopaminergic neurons in C. elegans.
18	J. David	Jentsch	jjentsch@binghamton.edu	Heritable differences in incentive motivation are genetically correlated with the excitability of dopamine release in the nucleus accumbens core of inbred mice
19	Emma	Johnson	emma.c.johnson@wustl.edu	2.) Multi-ancestral genome-wide association study of nicotine dependence reveals strong genetic correlations with other substance use and psychiatric disorders
20	Marcus	Kaul	marcus.kaul@medsch.ucr.edu	Chronic, low dose methamphetamine and HIV-1 Tat protein lead to neuronal injury, astrocyte activation and gene expression patterns displaying sexual dimorphism
21	Greg	Keele	gkeele@rti.org	Network biology algorithms identify biological pathways underlying cigarette smoking behaviors
22	Panjun	Kim	pkim11@uthsc.edu	Enhancer-Promoter interactions in rat prefrontal cortex identified by Hi-C sequencing facilitate functional interpretation of genetic association studies on substance abuse traits
23	Brittany	Kuhn	kuhnb@musc.edu	Genome wide association study reveals multiple loci associated with heroin motivation and taking behavior in heterogeneous stock rats
24	Lei	Li	Li129@iit.edu	Cross-modal Sensory Integration: A New Strategy for SUD Treatment
25	Zichong	Li	zichong.li@gladstone.ucsf.edu	Combinatorial Targeting of HIV Transcription: Impact of Cocaine and Morphine on Latency Reactivation
26	Shirelle X.	Liu	liu00459@umn.edu	Common and unique patterns of gene expression and chromatin accessibility in the rat medial prefrontal cortex across different phases of opioid use disorder
27	Falk W.	Lohoff	falk.lohoff@nih.gov	Multi-omics analyses of cortical proteome and single cell-type transcriptome identifies novel drug targets for problematic drinking behavior and alcohol use disorder
28	Andrew	Lombardi	anlo5057@colorado.edu	Role of GSCAN-Identified Genes in the Astrocytic Response to Nicotine
29	Chang	Lu	changlu@vt.edu	Low-input profiling of epigenomic dynamics in mouse brain to understand prolonged synaptic plasticity
30	William	Lynch	wlynch@bu.edu	Validating Zhx2 as a candidate gene underlying Oxycodone Metabolite (Oxymorphone) Brain Concentration and Behavior via Gene Editing and -Omics analyses in BALB/cByJ mice
31	Makoto	Taniguchi	Taniguch@musc.edu	A long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation
32	Min-Ae	Song	Song.991@osu.edu	A Potential Contribution of Acrylonitrile to Accelerated Epigenetic Aging of the Lungs of Smokers
33	Vivek	Swarup	vswarup@uci.edu	Unraveling Transcriptomic Dynamics: Interplay of Opioid Use Disorder and Early Life Adversity in Distinct Brain Regions
34	Vivek M.	Philip	vivek.philip@jax.org	Systems genetics and genomics data resources from the Center for Systems Neurogenetics of Addiction

May 24 – Poster Session C (10:20–11:45 a.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Brion	Maher	brion@jhu.edu	Brain Differential Methylation and Gene Expression following Opioid Overdose
2	Lisa	Maturin	lmaturin@health.ucsd.edu	The Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
3	Maria	Mavrikaki	mmavrika@bidmc.harvard.edu	Effects of oxycodone self-administration on gene and microRNA expression
4	Nicola	Micali	nicola.micali@yale.edu	Defining the effects of prenatal cannabinoid exposure on primate fetal brain development
5	Sophia	Miracle	smiracle@bu.edu	Effects of Zhx2 liver and brain overexpression on oxymorphone metabolite levels and state-dependent oxycodone reward learning in BALB/cJ mice with a Zhx2 loss-of-function variant
6	Amy	Moore	almoore@rti.org	Leveraging the All of Us Research Program to Better Understand the Genetic Architecture of Opioid Use Disorder Spectrum Behaviors
7	Anna	Moszczynska	ei2744@wayne.edu	Ubiquitin-Protein Ligase Parkin in Methamphetamine Use Disorder
8	Kateryna	Murlanova	kmurlano@buffalo.edu	Oprm1 deficiency in nucleus accumbens astrocytes increases sensitivity to heroin and reward consumption
9	Nathan	Nakatsuka	08nanaka@gmail.com	A Meta-Analysis Method for Finding Reproducible Differentially Expressed Genes in Single-Cell Transcriptomic Case-Control Studies
10	Jesse	Niehaus	jesse_niehaus@med.unc.edu	Accurately quantifying Oprm1 requires an updated gene annotation.
11	Steve	Oghumu	oghumu.1@osu.edu	Novel approach for the investigation of X-chromosome inactivation in mice exposed to addictive substances
12	Emmanuel	Onaivi	Onaivie@wpunj.edu	Cannabinoid type 2 receptor neuro-immune crosstalk following microglia and dopaminergic neuron specific deletion of CB2Rs.
13	Emily	Orr	eorr@wustl.edu	Applying high throughput deep mutational scanning to study transcription factors implicated in the biology of Substance Use Disorders
14	Abraham A.	Palmer	aap@ucsd.edu	Prescription Opioids Genetic Study (POGS) an innovative instrument for studying the genetic basis traits relevant to opioid use disorder.
15	Yezhi	Pan	ypan@som.umaryland.edu	Nicotine Addiction Functional Networks: A Whole-Brain Connectome Analysis in 24,000 Individuals
16	Ying-Xian	Pan	yx.pan@rutgers.edu	1.) Exploring molecular mechanisms underlying fentanyl overdose-induced toxicities via Oprm1 exon 1-associated variants using tandem mass tag-based phosphoproteomics/proteomics
17	Qian	Peng	qpeng@scripps.edu	Genetic Interactions in Alcohol Use Disorder in a High-Risk Population
18	Roseann E.	Peterson	roseann.peterson@downstate.edu	Expanded Empirical Population Assignments in Biobanks Empower Ancestrally Inclusive Genetic Studies of Substance Use Disorders
19	Chaitanya	Srinivasan	csriniv1@andrew.cmu.edu	Signatures of DNA Damage and Epigenetic Erosion in Opioid Use Disorder
20	No Poster
21	Marta	Pratelli	mpratelli@ucsd.edu	1.) Dopamine-induced change in transmitter phenotype is a shared mechanism for drug-induced generation of cognitive deficits
22	Elizabeth	Yen	elizabeth.yen2@tuftsmedicine.org	1.) Insulin Sensitivity and Body Composition Effects of Prenatal Opioid Exposure
23	Andrea D.	Raymond	adraymon@fiu.edu	Modulation of microRNA profiles in extracellular vesicles by HIV infection and opiates
24	Walker	Rogers	rogersw@vcu.edu	Investigating Transcriptomic Responses to Ethanol Analgesia Over Time in C57Bl/6J And DBA/2J Mouse Lines
25	Cheryl	Rosenfeld	RosenfeldC@missouri.edu	A Novel Single Nuclei Sequencing Approach to Examine Effects of Oxycodone on Parietal Trophoblast Giant Cells in the Mouse Placenta
26	Pavana	Rotti	protti@wi.mit.edu	Variant Enhancer Loci (VEL) due to Opioid Overdose Impact Forebrain Neuronal Function
27	Laura	Saba	Laura.Saba@cuanschutz.edu	Cell-type specific genetic effects and changes due to oxycodone exposure in RNA expression levels and co-expression networks in rat prefrontal cortex
28	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	Characterizing cases and controls for opioid use disorders using electronic health records: a phenomic and genomic exploration in over 1 million individuals
29	Pietro Paolo	Sanna	psanna@scripps.edu	Drug self-administration in a rodent model of HIV: from RNA-Seq to druggable targets.
30	Kirti	Sharma	sharmki@iu.edu	One person's nicotine addiction may affect another person's liver
31	Jakob (Koby)	Shaykin	k.shaykin@uky.edu	Genomic Assessment of the Prefrontal Cortex in Differential Responsivity of Sucrose Preference and Fentanyl Escalation in Sprague-Dawley Rats
32	Michael	Sheldon	Michael.Sheldon@sampled.com	The NIDA, ABCD, HBCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans
33	Jeremy	Sherman	jeremy.sherman@icahn.mssm.edu	Multimodal RNA-sequencing of the dorsal striatum identifies a link between H3K27 dysregulation and neurodegenerative phenotypes in heroin use.
34	Stephanie	Sillivan	stephanie.sillivan@temple.edu	Integrated analysis of sex-specific regulation of RNA networks in the rat orbitofrontal cortex following heroin self-administration
35	Gabriella	Silva	silvag2@vcu.edu	A zinc finger transcription factor in the nucleus accumbens regulates cocaine-induced transcription and behaviors in a cell type specific manner
36	N. Dalton	Fitzgerald	ndf@uab.edu	Neuronal activation by cocaine varies across molecularly-defined subpopulations of VTA dopamine neurons

May 24 – Poster Session D (2:30–4:00 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Madhurbain	Singh	singhm18@vcu.edu	Putative Proximal and Distal Effects between Smoking and Alcohol Consumption: Causal Inference from Models Integrating Polygenic Scores with Longitudinal Data
2	Omar	Soler-Cedeno	omar.soler-cedeno@nih.gov	Dissecting the functional roles of GABAergic vs. glutamatergic neurons in opioid reward using conditional mu opioid receptor-knockout mice
3	Jung Soo	Suk	jsuk@som.umaryland.edu	Combination of focused ultrasound and long-circulating nanoparticles for nucleic acid delivery to the brain
4	Kyle	Sullivan	sullivanka@ornl.gov	Multi-omic integration uncovers biological pathways underlying HIV viral load
5	Jing	Sun	jsun54@jhmi.edu	Reduced level of circulating cell-free nuclear and mitochondrial DNA fragments among Persons who Inject Drugs with HIV
6	Lisa	Tarantino	lisat@med.unc.edu	Repeated exposure to cocaine produces strain specific differences in incentive sensitization in Collaborative Cross mice
7	Zachary	Tatom	tatomz@vcu.edu	Car8 knockout in prefrontal cortex increases voluntary ethanol consumption in male mice
8	Francesca	Telese	ftelese@ucsd.edu	TSS-MPRA to decode regulatory functions of genetic variants associated with substance use disorders.
9	Stella	Tommasi	tommasi@med.usc.edu	Epigenomic dysregulation in youth vapers: implications for disease risk assessment
10	Guy	Twa	gtwa@uab.edu	Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns
11	Mudit	Tyagi	Mudit.Tyagi@jefferson.edu	Cocaine enhances HIV infection, gene expression and replication by stimulating cell metabolism
12	Alp Mete	Umnet	aummet@clemson.edu	Variation in Mushroom Body Morphology in Cocaine Preferring Drosophila Genetic Reference Panel Lines
13	Mary-Elizabeth	Zipparo	mzippar1@jhmi.edu	Past cocaine exposure durably alters CD4+ T-cell reservoir seeding and reactivation SIV-infected ART-suppressed macaques
14	Avinash	Veerappa	aveerappa@unmc.edu	OMICS Perspectives Unveil Neural Circuitry Adaptations in Chronic Heroin Addiction: A Genome-Wide Analysis of Epigenetic Signatures and Transcriptional Programs
15	Thao	Vu	thao.3.vu@cuanschutz.edu	Identification of blood metabolite biomarkers for oxycodone exposure in rats through metabolomics
16	Haohan	Wang	haohanw@illinois.edu	Understanding Variations in Regulatory Networks Across Cell Types through Transformer Model with Knowledge on Regulatory Interactions
17	Bradley T.	Webb	bwebb@rti.org	Deep ascertainment and genetic architecture of alcohol use disorder and related outcomes in All of Us.
18	Julie	White	jdwhite@rti.org	Comparison of DNA methylation signals across substances reveals shared biological implications for substance use
19	Caryn	Willis	cdwillis@rti.org	Meta-analyses of gene expression differences associated with alcohol use disorder in human brain
20	Kelly	Wingfield	kelwing@bu.edu	Exploring mouse ultrasonic vocalizations as a tool to study negative affective states in mice using a mouse model of neonatal opioid withdrawal syndrome (NOWS)
21	Zheng-Xiong	Xi	zxi@intra.nida.nih.gov	Neuronal versus glial CB2 receptor: Findings from a new strain of CB2-KO-EGFP reporter mice
22	Ke	Xu	Ke.Xu@yale.edu	Epigenome-wide characterization reveals aberrant DNA methylation of host genes regulating CD4+ T cell HIV-1 latent reservoir size in women living with HIV
23	Rongguang	Xu	roxu@bwh.harvard.edu	Investigating the Impact of Histone Post-Translational Modifications on Nucleosome Structure and Accessibility: Insights from Molecular Dynamics Studies
24	Ege A.	Yalcinbas	ege.yalcinbas@libd.org	Transcriptomic changes in habenula following chronic fentanyl self-administration in rats
25	Fengchun	Ye	fxy63@case.edu	Nurr-est neighbors: RXR induces epigenetic silencing of HIV-1 in microglial cells
26	Zhenyao	Ye	zye@som.umaryland.edu	Alcohol-Induced Alterations in Brain Functional Connectivity: Insights from Whole-Brain Data-Driven Analysis in Older Adults
27	Marta	Pratelli	mpratelli@ucsd.edu	2.) Pipeline for whole-brain analysis of METH-induced changes in neurotransmitter phenotype
28	Elizabeth	Yen	elizabeth.yen2@tuftsmedicine.org	2.) Molecular Evidence of Sex-Specific Effects in Neonates with Prenatal Opioid Exposure
29	Xinxu	Yuan	Xinxu.yuan@vcuhealth.org	All-in-one AAV delivery of multiplexed hypercompact OsCas12f/sgRNAs to eradicate HIV
30	Zhuzhu	Zhang	zhuzhuzhang@uchicago.edu	Single-Cell Resolution and Circuit-Level Dissection of Epigenomic Remodeling in Addiction
31	Jian	Zhu	jian.zhu@osumc.edu	Contribution of Methamphetamine-Induced Dysregulation of RNA Methylation to Promoting HIV Infection in Microglia/Macrophages
32	Lea	Zillich	lea.zillich@zi-mannheim.de	Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus suggests phosphodiesterases as a pharmacological target
33	Rajtarun	Madangopal	rajtarun.madangopal@nih.gov	In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
34	Katherine	Savell	Katherine.savell@nih.gov	Cell-type-specific transcriptional signatures of cocaine relapse in the rat medial prefrontal cortex

Past Genetic Meetings are available on the Archives site

May 18, 2024