What We Do:
The Branch supports research in the areas of medicinal chemistry, analytical chemistry, metabolism, pharmacokinetics and pharmacodynamics, pharmacogenetics and pharmaceutics/formulation development aimed at the design, evaluation and development of medications for the treatment of drug addiction.
The CPB supports research and provided services in support of clinical development in the following areas:
- Medicinal chemistry for the design and synthesis of new chemicals and structural classes with therapeutic potential including the applications of molecular modeling, structure-activity relationships, combinational techniques, and natural product approaches.
- Pharmaceutics for the design and development of new dosage forms to improve their therapeutic effectiveness and/or to minimize the abuse potential of potential treatment medications.
- Pharmacokinetics (PK) and pharmacodynamics of potential treatment medications.
- Pharmacogenetics to investigate the genetic variability affecting pharmacokinetics.
- Bioanalytical method development for quantifying treatment medications/metabolites, abused drugs and endogenous substances (as biomarkers) in biological fluids.
- Centralized bioanalytical resources to support PK studies and clinical trials.
- Bulk chemical synthesis (GMP and non GMP) and clinical dosage forms development and manufacture.
- Consultation and technical support on the aforementioned capabilities.