What We Do:
The CMB plans, designs, and implements a comprehensive program that evaluates, in a clinical setting, investigational and marketed medications for their potential value in treating substance abuse disorders. Potential medications are studied in both inpatient and outpatient clinical settings and can be managed through all phases of clinical development (Phases 1-4). CMB staff design protocols, monitor clinical trials, analyze data, and provide consultation and collaboration to the pharmaceutical industry, academia, and other interested parties regarding projects of mutual interest, study design, and data analysis. In addition, the CMB supports research training of clinicians to expand expertise in clinical research in methods as applied to medications development. The CMB files INDs in collaboration with the Regulatory Affairs Branch.
The CMB also includes the MCB grant portfolio.
The MCB plans, develops and administers a national and international program of research on medical/clinical/health consequences associated with drugs of abuse (licit [alcohol, tobacco, prescription medications] and illicit [amphetamines, cocaine, inhalants, marijuana, and others]) and their nexus to co-occurring viral and bacterial infections including HIV, hepatitis [B, C, D], tuberculosis, STIs, and others in humans (special studies in women, minorities, children and adolescents and underserved populations. Research may include, but not limited to, studies of the impact of drug addiction on medical/health conditions and the spread of infectious diseases and other conditions that might impact on all physiological or biochemical systems including role of nutrition in drug addiction and infectious diseases; morbidity, co-morbidity and mortality associated with drug use/abuse and/or infections; pathogenesis of drug abuse-associated HIV/AIDS and other co-occurring or opportunistic infectious diseases; medical intervention research concerning consequences of drug use/abuse and infections; pharmacokinetic and pharmacodynamic interactions between drugs of abuse and antiretroviral drugs; interactions between virus, host, and other factors in vulnerability and resistance to infection; pharmacological, physiological, genetic, and clinical factors in progression of infectious diseases in drug users/abusers; and promotes and supports research training and career development programs in the area of clinical/medical consequences.